⊟Summary[edit | edit source]

PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 05-APR-2025

⊟Summary

• organism: Streptococcus pneumoniae OXC141
locus tag: SPNOXC_RS07595 [old locus tags: SPNOXC14070 SPNOXC_14070 ]
pan locus tag^?: PNEUPAN002992000
symbol: cmk
pan gene symbol^?: cmk
• synonym:
• product: (d)CMP kinase

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SPNOXC_RS07595 [old locus tags: SPNOXC14070 SPNOXC_14070 ]
• symbol: cmk
• product: (d)CMP kinase
• replicon: chromosome
• strand: -
• coordinates: 1426257..1426928
• length: 672
• essential: unknown

⊟Accession numbers

• Location: NC_017592 (1426257..1426928) NCBI
• BioCyc: SPNOXC_RS07595 BioCyc
• MicrobesOnline:
• PneumoBrowse for strain D39V: SPV_1428 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  
  ATGAAAACAATTCAAATTGCTATTGATGGTCCTGCTTCCAGCGGTAAGAGTACGGTCGCA
  AAGATTATTGCTAAGGATTTTGGATTCACCTACCTTGATACAGGAGCTATGTATCGTGCA
  GCGACCTATATGGCTCTTAAGAACCAATTAGGAGTTGAAGAAGTCGAAGCCCTTCTAGCC
  TTGTTGGACCAGCATTCAATCAGCTTTGGACGTTCAGAAACTGGAGACCAGCTTGTTTTT
  GTAGGAGATGTGGATATTACCCATCCTATCCGTGAAAATGAAGTGACCAATCATGTTTCT
  GCTATTGCAGCAATTCCTGAAGTGCGTAAGAAATTGGTTTCTCTCCAACAAGAAATTGCC
  CAGCAAGGCGGGATTGTCATGGATGGTCGCGATATTGGAACTGTTGTATTGCCACAAGCA
  GAATTGAAAATTTTCCTAGTAGCTTCTGTTGATGAGAGAGCAGAGCGTCGTTACAAGGAA
  AATATTGCCAAGGGAATTGAAACAGACCTTGAAACCCTAAAAAAGGAAATTGCTGCGCGT
  GACTACAAGGATAGTCATCGTGAGACTTCTCCTCTCAAACAAGCAGAGGATGCTGTCTAC
  CTTGATACAACTGGTTTGAACATTCAAGAAGTAGTTGAAAAAATCAAAGCAGAAGCTGAA
  AAAAGAATGTAA
  60
  120
  180
  240
  300
  360
  420
  480
  540
  600
  660
  672
  

⊟Protein

⊟General

• locus tag: SPNOXC_RS07595 [old locus tags: SPNOXC14070 SPNOXC_14070 ]
• symbol: Cmk
• description: (d)CMP kinase
• length: 223
• theoretical pI: 4.92126
• theoretical MW: 24586.9
• GRAVY: -0.243946

⊟Function

• ⊞⊞reaction:
  EC 2.7.4.25?  ExPASy
  (d)CMP kinase ATP + (d)CMP = ADP + (d)CDP
• ⊞⊞TIGRFAM:
  Metabolism Purines, pyrimidines, nucleosides, and nucleotides Nucleotide and nucleoside interconversions cytidylate kinase (TIGR00017; EC 2.7.4.14; HMM-score: 265.4)
  and 8 more
  putative cytidylate kinase (TIGR02173; EC 2.7.4.14; HMM-score: 50.8)
  Metabolism Purines, pyrimidines, nucleosides, and nucleotides Nucleotide and nucleoside interconversions adenylate kinase (TIGR01351; EC 2.7.4.-; HMM-score: 20.3)
  Metabolism Purines, pyrimidines, nucleosides, and nucleotides Salvage of nucleosides and nucleotides uridine kinase (TIGR00235; EC 2.7.1.48; HMM-score: 15.7)
  Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Pantothenate and coenzyme A dephospho-CoA kinase (TIGR00152; EC 2.7.1.24; HMM-score: 15.6)
  UMP-CMP kinase family (TIGR01359; EC 2.7.4.-; HMM-score: 15)
  adenylate kinase (TIGR01360; EC 2.7.4.3; HMM-score: 14.9)
  carbohydrate kinase, thermoresistant glucokinase family (TIGR01313; EC 2.7.1.-; HMM-score: 13.9)
  nicotinamide-nucleotide adenylyltransferase (TIGR01526; EC 2.7.7.1; HMM-score: 12.7)
• TheSEED: see SPNOXC14070
• ⊞⊞PFAM:
  P-loop_NTPase (CL0023) Cytidylate_kin; Cytidylate kinase (PF02224; HMM-score: 258.4)
  and 12 more
  Cytidylate_kin2; Cytidylate kinase-like family (PF13189; HMM-score: 38)
  AAA_18; AAA domain (PF13238; HMM-score: 26.6)
  SKI; Shikimate kinase (PF01202; HMM-score: 21.3)
  ADK; Adenylate kinase (PF00406; HMM-score: 20.6)
  AAA_17; AAA domain (PF13207; HMM-score: 20.6)
  dNK; Deoxynucleoside kinase (PF01712; HMM-score: 19)
  AAA_33; AAA domain (PF13671; HMM-score: 15.5)
  AAA; ATPase family associated with various cellular activities (AAA) (PF00004; HMM-score: 13.9)
  ABC_tran; ABC transporter (PF00005; HMM-score: 13.8)
  no clan defined SASP; Small, acid-soluble spore proteins, alpha/beta type (PF00269; HMM-score: 13.2)
  TPR_MLP1_2; TPR/MLP1/MLP2-like protein (PF07926; HMM-score: 12.1)
  P-loop_NTPase (CL0023) CobU; Cobinamide kinase / cobinamide phosphate guanyltransferase (PF02283; HMM-score: 11.6)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• ⊞⊞PSORTb: Cytoplasmic
  • Cytoplasmic Score: 9.97
  • Cytoplasmic Membrane Score: 0
  • Cellwall Score: 0.01
  • Extracellular Score: 0.02
  • Internal Helices: 0
• ⊞⊞SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.006888
  • TAT(Tat/SPI): 0.000374
  • LIPO(Sec/SPII): 0.000742
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: WP_000849383 NCBI
• UniProt:

⊟Protein sequence

• MKTIQIAIDGPASSGKSTVAKIIAKDFGFTYLDTGAMYRAATYMALKNQLGVEEVEALLALLDQHSISFGRSETGDQLVFVGDVDITHPIRENEVTNHVSAIAAIPEVRKKLVSLQQEIAQQGGIVMDGRDIGTVVLPQAELKIFLVASVDERAERRYKENIAKGIETDLETLKKEIAARDYKDSHRETSPLKQAEDAVYLDTTGLNIQEVVEKIKAEAEKRM

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator:

⊟Expression data

• PneumoExpress for strain D39V: SPV_1428 PneumoExpress

⊞Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊞Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications