⊟Summary[edit | edit source]

PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 07-FEB-2021

⊟Summary

• organism: Streptococcus pneumoniae AP200
locus tag: SPAP_RS01250 [old locus tag: SPAP_0255 ]
pan locus tag^?: PNEUPAN000942000
symbol: SPAP_RS01250
pan gene symbol^?: udk_1
• synonym:
• product: phosphoribulokinase

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SPAP_RS01250 [old locus tag: SPAP_0255 ]
• symbol: SPAP_RS01250
• product: phosphoribulokinase
• replicon: chromosome
• strand: +
• coordinates: 230582..231166
• length: 585
• essential: unknown

⊟Accession numbers

• Location: NC_014494 (230582..231166) NCBI
• BioCyc: SPAP_RS01250 BioCyc
• MicrobesOnline:
• PneumoBrowse for strain D39V: SPV_0191 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  
  ATGAAGAAAAAAGACTTAGTAGACCAACTAGTCTCAGCGATCGAGACGGGGAAAGTCAGG
  ACACTGGGAATATACGGTCATGGAGCTTCAGGTAAATCAACCTTTGCACAGGAATTGTAC
  CAAGCTTTAGATTCTACTACAGTAAATTTGCTAGAGACAGATCCTTATATCACCTCAGGA
  CGCCATCTGGTAGTACCCAAGGACGCGCCGAATCAAAAGGTGACAGCCAGTCTGCCAGTG
  GCGCATGAACTGGAGAGTTTGCAGAGAGATATCCTTGCCTTGCAGGCGGGTATGGATGTC
  TTGACAATTGAAGAACCTTGGAAGGCTAGTGAGGTCTTGTCTGGAGCCAAACCAATTTTG
  ATTGTCGAAGGGATGTCTGTTGGTTTTCTACCCAAGGAACTCTTTGAAAAAACCATCTGT
  TTCTACACGGATGAGGAGACCGAATTAAAGCGACGCCTTGCTAGAGATACGACTGTGAGA
  AATCGCGATGCATCCTTTATATTGGCTAGCCATCAGATGAGACGGGAGCAGTATCTGCGA
  TACTATAAAGAAACTGAGTCTAAGGCGGATATCTTAGTGGACTAA
  60
  120
  180
  240
  300
  360
  420
  480
  540
  585
  

⊟Protein

⊟General

• locus tag: SPAP_RS01250 [old locus tag: SPAP_0255 ]
• symbol: SPAP_RS01250
• description: phosphoribulokinase
• length: 194
• theoretical pI: 5.72484
• theoretical MW: 21801.8
• GRAVY: -0.312887

⊟Function

• ⊞⊞TIGRFAM:
  Metabolism Purines, pyrimidines, nucleosides, and nucleotides Salvage of nucleosides and nucleotides uridine kinase (TIGR00235; EC 2.7.1.48; HMM-score: 45.8)
  and 7 more
  Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Pantothenate and coenzyme A dephospho-CoA kinase (TIGR00152; EC 2.7.1.24; HMM-score: 13)
  Metabolism Transport and binding proteins Unknown substrate energy-coupling factor transporter ATPase (TIGR04521; EC 3.6.3.-; HMM-score: 12.6)
  Metabolism Central intermediary metabolism Nitrogen fixation nitrogenase iron protein (TIGR01287; EC 1.18.6.1; HMM-score: 12.3)
  Metabolism Transport and binding proteins Amino acids, peptides and amines LAO/AO transport system ATPase (TIGR00750; EC 2.7.-.-; HMM-score: 11.7)
  Signal transduction Regulatory functions Protein interactions LAO/AO transport system ATPase (TIGR00750; EC 2.7.-.-; HMM-score: 11.7)
  Genetic information processing DNA metabolism DNA replication, recombination, and repair phage/plasmid primase, P4 family, C-terminal domain (TIGR01613; HMM-score: 11.7)
  Genetic information processing Mobile and extrachromosomal element functions Prophage functions phage/plasmid primase, P4 family, C-terminal domain (TIGR01613; HMM-score: 11.7)
• TheSEED: see SPAP_0255
• ⊞⊞PFAM:
  P-loop_NTPase (CL0023) PRK; Phosphoribulokinase / Uridine kinase family (PF00485; HMM-score: 46.1)
  and 12 more
  AAA_16; AAA ATPase domain (PF13191; HMM-score: 21.8)
  AAA_18; AAA domain (PF13238; HMM-score: 21.1)
  AAA_33; AAA domain (PF13671; HMM-score: 20)
  AAA_17; AAA domain (PF13207; HMM-score: 16.8)
  CoaE; Dephospho-CoA kinase (PF01121; HMM-score: 15.7)
  Thymidylate_kin; Thymidylate kinase (PF02223; HMM-score: 15)
  NB-ARC; NB-ARC domain (PF00931; HMM-score: 13.2)
  KTI12; Chromatin associated protein KTI12 (PF08433; HMM-score: 12.7)
  ATP_bind_1; Conserved hypothetical ATP binding protein (PF03029; HMM-score: 12.2)
  MeaB; Methylmalonyl Co-A mutase-associated GTPase MeaB (PF03308; HMM-score: 12)
  Fer4_NifH; 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family (PF00142; HMM-score: 11.5)
  no clan defined PSII; Photosystem II protein (PF00421; HMM-score: 9.9)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• ⊞⊞PSORTb: Cytoplasmic Membrane
  • Cytoplasmic Score: 1.78
  • Cytoplasmic Membrane Score: 8.16
  • Cellwall Score: 0.06
  • Extracellular Score: 0.01
  • Internal Helices: 0
• ⊞⊞SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.052656
  • TAT(Tat/SPI): 0.010934
  • LIPO(Sec/SPII): 0.004957
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: WP_000725981 NCBI
• UniProt:

⊟Protein sequence

• MKKKDLVDQLVSAIETGKVRTLGIYGHGASGKSTFAQELYQALDSTTVNLLETDPYITSGRHLVVPKDAPNQKVTASLPVAHELESLQRDILALQAGMDVLTIEEPWKASEVLSGAKPILIVEGMSVGFLPKELFEKTICFYTDEETELKRRLARDTTVRNRDASFILASHQMRREQYLRYYKETESKADILVD

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• data available for D39

⊟Expression data

• PneumoExpress for strain D39V: SPV_0191 PneumoExpress

⊞Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊞Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications