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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 09-FEB-2021

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae 6A-10
  • locus tag: HKM25_RS01075 [old locus tag: HKM25_218 ]
  • pan locus tag?: PNEUPAN000942000
  • symbol: HKM25_RS01075
  • pan gene symbol?: udk_1
  • synonym:
  • product: phosphoribulokinase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: HKM25_RS01075 [old locus tag: HKM25_218 ]
  • symbol: HKM25_RS01075
  • product: phosphoribulokinase
  • replicon: chromosome
  • strand: +
  • coordinates: 202571..203188
  • length: 618
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_CP053210 (202571..203188) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0191 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    ATGAAGAAAAAAGACTTAGTAGACCAACTAGTCTCAGAGATCGAGACGGGGAAAGTCAGG
    ACACTGGGAATATACGGTCATGGAGCTTCAGGTAAATCAACCTCTGCACAGGAATTGTAC
    CAAGCTTTAGATTCTACTACAGTAAATTTGCTAGAAACAGATCCCTATATCACCTCAGGA
    CGCCATCTGGTAGTACCCAAGGACGCGCCGAATCAAAAGGTGACAGCCGGTCTGCCAGTG
    GCGCATGAACTGGAGAGTTTGCAGAGAGATATCCTTGCCTTGCAGGCGAGTATGGATGTC
    TTGACAATTGAAGAACCTTGGAAGGCTAGTGAGGTCTTGTCTGGAGCCAAACCAATTTTG
    ATTGTCGAAGGGATGTCTGTTGGCTTTCGACCCAAGGAACTCTTTGAAAAAACCATCTGT
    TTCTACACGGATGAGGAGACCGAATTAAAGCGACGCCTTGCTAGAGATACGACTGTGAGA
    AATCGTGATGCATCCTTTATATTGGCTAGCCATCAGATGAGACGGGAGCAGTATCTGCGA
    TACTATAAAGAAACTGAGTCTAAGGCGGATATCTTAGTGGATCAATCAGAAGATAAATTT
    GATGTCAAGAGGACTTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    618

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: HKM25_RS01075 [old locus tag: HKM25_218 ]
  • symbol: HKM25_RS01075
  • description: phosphoribulokinase
  • length: 205
  • theoretical pI: 5.75405
  • theoretical MW: 23177.2
  • GRAVY: -0.481463

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Salvage of nucleosides and nucleotides uridine kinase (TIGR00235; EC 2.7.1.48; HMM-score: 48.7)
    and 2 more
    Metabolism Central intermediary metabolism Nitrogen fixation nitrogenase iron protein (TIGR01287; EC 1.18.6.1; HMM-score: 12.6)
    arsenical pump-driving ATPase (TIGR04291; EC 3.6.1.-; HMM-score: 11.2)
  • TheSEED: data available for D39, Hungary19A-6
  • PFAM:
    P-loop_NTPase (CL0023) PRK; Phosphoribulokinase / Uridine kinase family (PF00485; HMM-score: 44.2)
    and 8 more
    AAA_16; AAA ATPase domain (PF13191; HMM-score: 21.8)
    AAA_18; AAA domain (PF13238; HMM-score: 19)
    AAA_33; AAA domain (PF13671; HMM-score: 15.3)
    CoaE; Dephospho-CoA kinase (PF01121; HMM-score: 15.1)
    AAA_17; AAA domain (PF13207; HMM-score: 14.3)
    Thymidylate_kin; Thymidylate kinase (PF02223; HMM-score: 13.9)
    Fer4_NifH; 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family (PF00142; HMM-score: 12.7)
    no clan defined Sortase; Sortase domain (PF04203; HMM-score: 12.2)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 1.78
    • Cytoplasmic Membrane Score: 8.16
    • Cellwall Score: 0.06
    • Extracellular Score: 0.01
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.032448
    • TAT(Tat/SPI): 0.00837
    • LIPO(Sec/SPII): 0.005188
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000725999 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKKKDLVDQLVSEIETGKVRTLGIYGHGASGKSTSAQELYQALDSTTVNLLETDPYITSGRHLVVPKDAPNQKVTAGLPVAHELESLQRDILALQASMDVLTIEEPWKASEVLSGAKPILIVEGMSVGFRPKELFEKTICFYTDEETELKRRLARDTTVRNRDASFILASHQMRREQYLRYYKETESKADILVDQSEDKFDVKRT

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • data available for D39

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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