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From PneumoWiki
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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 17-JAN-2018

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae AP200
  • locus tag: SPAP_0960 [new locus tag: SPAP_RS04765 ]
  • pan locus tag?: PNEUPAN001934000
  • symbol: SPAP_0960
  • pan gene symbol?: lspA
  • synonym:
  • product: Lipoprotein signal peptidase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPAP_0960 [new locus tag: SPAP_RS04765 ]
  • symbol: SPAP_0960
  • product: Lipoprotein signal peptidase
  • replicon: chromosome
  • strand: +
  • coordinates: 915586..916047
  • length: 462
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    ATGAAAAAAAGAGCAATAGTGGCAGTCATTGTACTGCTTTTAATTGGGCTGGATCAGTTG
    GTCAAATCCTATATCGTCCAGCAGATTCCACTGGGTGAAGTGCGCTCCTGGATTCCCAAT
    TTCGTTAGCTTGACCTACCTGCAAAATCGAGGTGCAGCCTTTTCTATCTTACAAGATCAG
    CAGCTGTTATTCGCTGTCATTACTCTGGTTGTCGTGATAGGTGCCATTTGGTATTTACAT
    AAACACATGGAGGACTCATTCTGGATGGTCTTGGGTTTGACTTTGATAATCGCGGGTGGT
    CTTGGAAACTTTATTGACAGGGCCAGTCAGGGCTTTGTTGTGGATATGTTCCACCTTGAC
    TTTATCAACTTTGCAATTTTCAATGTGGCAGATAGCTATCTGACGGTTGGAGTGATTATT
    TTATTGATTGCAATGCTAAAAGAGGAAATAAATGGAAATTAA
    60
    120
    180
    240
    300
    360
    420
    462

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPAP_0960 [new locus tag: SPAP_RS04765 ]
  • symbol: SPAP_0960
  • description: Lipoprotein signal peptidase
  • length: 153
  • theoretical pI: 6.23647
  • theoretical MW: 17122.3
  • GRAVY: 0.887582

⊟Function[edit | edit source]

  • ⊞⊞TIGRFAM:
    Genetic information processing Protein fate Protein and peptide secretion and trafficking signal peptidase II (TIGR00077; EC 3.4.23.36; HMM-score: 122.6)
    and 1 more
    Cell structure Cell envelope Other LPXTG cell wall anchor domain (TIGR01167; HMM-score: 5.1)
  • ⊞⊞TheSEED  :
    • Lipoprotein signal peptidase (EC 3.4.23.36)
    Protein Metabolism Protein processing and modification Lipoprotein Biosynthesis  Lipoprotein signal peptidase (EC 3.4.23.36)
    and 1 more
    Protein Metabolism Protein processing and modification Signal peptidase  Lipoprotein signal peptidase (EC 3.4.23.36)
  • ⊞⊞PFAM:
    no clan defined Peptidase_A8; Signal peptidase (SPase) II (PF01252; HMM-score: 127.7)
    and 4 more
    DUF6594; Family of unknown function (DUF6594) (PF20237; HMM-score: 11.8)
    MFS (CL0015) OATP; Organic Anion Transporter Polypeptide (OATP) family (PF03137; HMM-score: 10.9)
    no clan defined PrgI; PrgI family protein (PF12666; HMM-score: 9.3)
    TMEM_230_134; Transmembrane proteins 230/134 (PF05915; HMM-score: 7.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • ⊞⊞PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 4
  • ⊞⊞SignalP: Signal peptide SP(Sec/SPI) length 23 aa
    • SP(Sec/SPI): 0.501891
    • TAT(Tat/SPI): 0.000482
    • LIPO(Sec/SPII): 0.044322
    • Cleavage Site: CS pos: 23-24. VKS-YI. Pr: 0.4361
  • predicted transmembrane helices (TMHMM): 4

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: ADM84549 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKKRAIVAVIVLLLIGLDQLVKSYIVQQIPLGEVRSWIPNFVSLTYLQNRGAAFSILQDQQLLFAVITLVVVIGAIWYLHKHMEDSFWMVLGLTLIIAGGLGNFIDRASQGFVVDMFHLDFINFAIFNVADSYLTVGVIILLIAMLKEEINGN

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Suneeta Khandavilli, Karen A Homer, Jose Yuste, Shilpa Basavanna, Timothy Mitchell, Jeremy S Brown
Maturation of Streptococcus pneumoniae lipoproteins by a type II signal peptidase is required for ABC transporter function and full virulence.
Mol Microbiol: 2008, 67(3);541-57
[PubMed:18086214] [WorldCat.org] [DOI] (P p)

Retrieved from "http://pneumowiki.med.uni-greifswald.de/index.php?title=SPAP_0960&oldid=43152"
Insert paragraph

NCBI: 17-JAN-2018

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae AP200
  • locus tag: SPAP_0960 [new locus tag: SPAP_RS04765 ]
  • pan locus tag?: PNEUPAN001934000
  • symbol: SPAP_0960
  • pan gene symbol?: lspA
  • synonym:
  • product: Lipoprotein signal peptidase

Insert paragraph

⊟Genome View[edit | edit source]

Insert paragraph

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPAP_0960 [new locus tag: SPAP_RS04765 ]
  • symbol: SPAP_0960
  • product: Lipoprotein signal peptidase
  • replicon: chromosome
  • strand: +
  • coordinates: 915586..916047
  • length: 462
  • essential: unknown

Insert paragraph

⊟Accession numbers[edit | edit source]

Insert paragraph

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    ATGAAAAAAAGAGCAATAGTGGCAGTCATTGTACTGCTTTTAATTGGGCTGGATCAGTTG
    GTCAAATCCTATATCGTCCAGCAGATTCCACTGGGTGAAGTGCGCTCCTGGATTCCCAAT
    TTCGTTAGCTTGACCTACCTGCAAAATCGAGGTGCAGCCTTTTCTATCTTACAAGATCAG
    CAGCTGTTATTCGCTGTCATTACTCTGGTTGTCGTGATAGGTGCCATTTGGTATTTACAT
    AAACACATGGAGGACTCATTCTGGATGGTCTTGGGTTTGACTTTGATAATCGCGGGTGGT
    CTTGGAAACTTTATTGACAGGGCCAGTCAGGGCTTTGTTGTGGATATGTTCCACCTTGAC
    TTTATCAACTTTGCAATTTTCAATGTGGCAGATAGCTATCTGACGGTTGGAGTGATTATT
    TTATTGATTGCAATGCTAAAAGAGGAAATAAATGGAAATTAA
    60
    120
    180
    240
    300
    360
    420
    462

Insert paragraph

This data comes from external databases and cannot be edited.

Insert paragraph

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPAP_0960 [new locus tag: SPAP_RS04765 ]
  • symbol: SPAP_0960
  • description: Lipoprotein signal peptidase
  • length: 153
  • theoretical pI: 6.23647
  • theoretical MW: 17122.3
  • GRAVY: 0.887582

Insert paragraph

⊟Function[edit | edit source]

  • ⊞TIGRFAM:
    Genetic information processing Protein fate Protein and peptide secretion and trafficking signal peptidase II (TIGR00077; EC 3.4.23.36; HMM-score: 122.6)
    and 1 more
    Cell structure Cell envelope Other LPXTG cell wall anchor domain (TIGR01167; HMM-score: 5.1)
  • ⊞TheSEED  :
    • Lipoprotein signal peptidase (EC 3.4.23.36)
    Protein Metabolism Protein processing and modification Lipoprotein Biosynthesis  Lipoprotein signal peptidase (EC 3.4.23.36)
    and 1 more
    Protein Metabolism Protein processing and modification Signal peptidase  Lipoprotein signal peptidase (EC 3.4.23.36)
  • ⊞PFAM:
    no clan defined Peptidase_A8; Signal peptidase (SPase) II (PF01252; HMM-score: 127.7)
    and 4 more
    DUF6594; Family of unknown function (DUF6594) (PF20237; HMM-score: 11.8)
    MFS (CL0015) OATP; Organic Anion Transporter Polypeptide (OATP) family (PF03137; HMM-score: 10.9)
    no clan defined PrgI; PrgI family protein (PF12666; HMM-score: 9.3)
    TMEM_230_134; Transmembrane proteins 230/134 (PF05915; HMM-score: 7.6)

Insert paragraph

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

Insert paragraph

⊟Localization[edit | edit source]

  • ⊞PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 4
  • ⊞SignalP: Signal peptide SP(Sec/SPI) length 23 aa
    • SP(Sec/SPI): 0.501891
    • TAT(Tat/SPI): 0.000482
    • LIPO(Sec/SPII): 0.044322
    • Cleavage Site: CS pos: 23-24. VKS-YI. Pr: 0.4361
  • predicted transmembrane helices (TMHMM): 4

Insert paragraph

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: ADM84549 NCBI
  • UniProt:

Insert paragraph

⊟Protein sequence[edit | edit source]

  • MKKRAIVAVIVLLLIGLDQLVKSYIVQQIPLGEVRSWIPNFVSLTYLQNRGAAFSILQDQQLLFAVITLVVVIGAIWYLHKHMEDSFWMVLGLTLIIAGGLGNFIDRASQGFVVDMFHLDFINFAIFNVADSYLTVGVIILLIAMLKEEINGN

Insert paragraph

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

Insert paragraph

⊟Expression & Regulation[edit | edit source]

Insert paragraph

⊟Operon[edit | edit source]

Insert paragraph

⊟Regulation[edit | edit source]

  • regulator:

Insert paragraph

⊟Expression data[edit | edit source]

Insert paragraph

⊞Biological Material[edit | edit source]

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

⊞Other Information[edit | edit source]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

Insert paragraph

⊟Relevant publications[edit | edit source]

Suneeta Khandavilli, Karen A Homer, Jose Yuste, Shilpa Basavanna, Timothy Mitchell, Jeremy S Brown
Maturation of Streptococcus pneumoniae lipoproteins by a type II signal peptidase is required for ABC transporter function and full virulence.
Mol Microbiol: 2008, 67(3);541-57
[PubMed:18086214] [WorldCat.org] [DOI] (P p)

Insert paragraph