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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 05-APR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae OXC141
  • locus tag: SPNOXC_RS02055 [old locus tags: SPNOXC03790 SPNOXC_03790 ]
  • pan locus tag?: PNEUPAN001268000
  • symbol: mvaD
  • pan gene symbol?: mvaD
  • synonym:
  • product: diphosphomevalonate decarboxylase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPNOXC_RS02055 [old locus tags: SPNOXC03790 SPNOXC_03790 ]
  • symbol: mvaD
  • product: diphosphomevalonate decarboxylase
  • replicon: chromosome
  • strand: +
  • coordinates: 377624..378577
  • length: 954
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Location: NC_017592 (377624..378577) NCBI
  • BioCyc: SPNOXC_RS02055 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0347 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    ATGGATAGAGAGCCTGTAACAGTACGTTCCTACGCAAATATTGCTATTATCAAATATTGG
    GGAAAGAAAAAAGAAAAAGAGATGGTGCCTGCTACTAGCAGTATTTCTCTAACTTTGGAA
    AATATGTATACAGAGACGACCTTGTCGCCTTTACCAGCCAATGTAACAGCTGACGAATTT
    TACATCAATGGTCAGCTACAAAATGAGGTCGAGCATGCCAAGATGAGTAAGATTATTGAC
    CGTTATCGTCCAGCTGGTGAGGGCTTTGTCCGTATCGATACTCAAAACAATATGCCTACG
    GCAGCGGGCCTGTCCTCAAGTTCTAGTGGTTTGTCCGCCCTGGTCAAGGCTTGTAATGCT
    TATTTCAAGCTTGGATTGGATAGAAGTCAGTTGGCACAGGAAGCCAAATTTGCCTCAGGC
    TCTTCTTCTCGGAGTTTTTATGGACCACTAGGAGCCTGGGATAAGGATAGTGGAGAAATT
    TACCCTGTAGAGACAGACTTGAAACTAGCTATGATTATGTTGGTGCTAGAGGACAAGAAA
    AAACCAATCTCTAGCCGTGACGGGATGAAACTTTGTGTGGAAACCTCGACGACTTTTGAC
    GACTGGGTTCGTCAGTCTGAGAAGGACTATCAGGATATGCTGATTTATCTCAAGGAAAAT
    GATTTTGCCAAGATTGGAGAATTAACGGAGAAAAATGCTCTGGCTATGCATGCTACGACA
    AAGACTGCTAGTCCAGCCTTTTCTTATCTGACGGATGCCTCTTATGAGGCTATGGCCTTT
    GTTCGCCAGCTTCGTGAGAAAGGAGAGGCCTGCTACTTTACCATGGATGCTGGTCCCAAT
    GTTAAGGTCTTCTGTCAGGAGAAAGACTTGGAGCATTTGTCAGAAATTTTCGGTCAGCGT
    TATCGCTTGATTGTGTCAAAAACAAAGGATTTGAGTCAAGATGATTGCTGTTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    954

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPNOXC_RS02055 [old locus tags: SPNOXC03790 SPNOXC_03790 ]
  • symbol: MvaD
  • description: diphosphomevalonate decarboxylase
  • length: 317
  • theoretical pI: 5.1468
  • theoretical MW: 35533.2
  • GRAVY: -0.41388

⊟Function[edit | edit source]

  • ⊞reaction:
    EC 4.1.1.33?  ExPASy
    Diphosphomevalonate decarboxylase ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO2
  • ⊞TIGRFAM:
    Metabolism Central intermediary metabolism Other diphosphomevalonate decarboxylase (TIGR01240; EC 4.1.1.33; HMM-score: 417.9)
    and 6 more
    Metabolism Amino acid biosynthesis Aromatic amino acid family shikimate kinase (TIGR01920; EC 2.7.1.71; HMM-score: 21.8)
    Metabolism Central intermediary metabolism Other mevalonate kinase (TIGR00549; EC 2.7.1.36; HMM-score: 20.6)
    Metabolism Amino acid biosynthesis Aspartate family homoserine kinase (TIGR00191; EC 2.7.1.39; HMM-score: 18.2)
    Metabolism Energy metabolism Sugars galactokinase (TIGR00131; EC 2.7.1.6; HMM-score: 17.1)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase (TIGR00154; EC 2.7.1.148; HMM-score: 14.6)
    Unknown function Enzymes of unknown specificity secondary thiamine-phosphate synthase enzyme (TIGR00149; HMM-score: 12.2)
  • TheSEED: see SPNOXC03790
  • ⊞PFAM:
    GHMP_C (CL0677) MDD_C; Mevalonate 5-diphosphate decarboxylase C-terminal domain (PF18376; HMM-score: 78)
    and 2 more
    S5 (CL0329) GHMP_kinases_N; GHMP kinases N terminal domain (PF00288; HMM-score: 35)
    RRM (CL0221) RRM_5; RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (PF13893; HMM-score: 16.7)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • ⊞PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • ⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.015776
    • TAT(Tat/SPI): 0.001448
    • LIPO(Sec/SPII): 0.001588
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000373456 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MDREPVTVRSYANIAIIKYWGKKKEKEMVPATSSISLTLENMYTETTLSPLPANVTADEFYINGQLQNEVEHAKMSKIIDRYRPAGEGFVRIDTQNNMPTAAGLSSSSSGLSALVKACNAYFKLGLDRSQLAQEAKFASGSSSRSFYGPLGAWDKDSGEIYPVETDLKLAMIMLVLEDKKKPISSRDGMKLCVETSTTFDDWVRQSEKDYQDMLIYLKENDFAKIGELTEKNALAMHATTKTASPAFSYLTDASYEAMAFVRQLREKGEACYFTMDAGPNVKVFCQEKDLEHLSEIFGQRYRLIVSKTKDLSQDDCC

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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