⊟Summary[edit | edit source]

PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BM6001

serotype 19F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7465

serotype 1

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 08-SEP-2024

⊟Summary

• organism: Streptococcus pneumoniae D39V
locus tag: SPV_RS00265 [old locus tag: SPV_0054 ]
pan locus tag^?: PNEUPAN000672000
symbol: purM
pan gene symbol^?: purM
• synonym:
• product: phosphoribosylformylglycinamidine cyclo-ligase

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SPV_RS00265 [old locus tag: SPV_0054 ]
• symbol: purM
• product: phosphoribosylformylglycinamidine cyclo-ligase
• replicon: chromosome
• strand: +
• coordinates: 51793..52815
• length: 1023
• essential: unknown

⊟Accession numbers

• Location: NZ_CP027540 (51793..52815) NCBI
• BioCyc: see SPV_0054
• MicrobesOnline:
• PneumoBrowse: SPV_0054 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  721
  781
  841
  901
  961
  1021
  
  ATGACAAATAAAAATGCATATGCCCAGTCGGGTGTGGATGTTGAAGCGGGTTATGAAGTT
  GTTGAACGGATTAAAAAGCACGTGGCCCGTACGGAGCGTGCAGGTGTCATGGGAGCTCTT
  GGTGGCTTTGGTGGTATGTTTGACCTTTCCAAGACTGGGGTTAAAGAACCCGTCTTGATT
  TCAGGGACTGACGGTGTCGGAACCAAGCTCATGTTGGCTATCAAGTACGACAAGCACGAT
  ACCATCGGGCAGGACTGTGTGGCCATGTGTGTCAACGACATCATTGCTGCAGGTGCGGAA
  CCCCTCTATTTTCTCGACTACGTAGCGACAGGGAAGAATGAACCAGCTAAGCTAGAACAA
  GTGGTTGCTGGTGTGGCAGAAGGTTGTGTGCAGGCTGGTGCTGCCCTCATCGGTGGGGAA
  ACGGCTGAAATGCCGGGCATGTACGGCGAAGACGACTATGACTTGGCTGGTTTTGCGGTC
  GGTGTGGCTGAAAAATCTCAAATCATTGACGGTTCAAAGGTGGTAGAGGGAGATGTTCTT
  CTCGGACTTGTTTCAAGTGGGATTCACTCAAATGGTTACTCTTTGGTTCGTCGTGTCTTT
  GCGGATTACACAGGTGAGGAAGTCCTACCAGAATTGGAAGGCAAGAAACTTAAGGAAGTT
  CTACTTGAGCCGACTCGTATCTATGTCAAGGCTGTCTTGCCGCTCATCAAAGAAGAGTTG
  GTCAACGGCATTGCCCACATCACAGGTGGTGGCTTTATCGAAAATGTCCCTCGTATGTTT
  GCAGATGACCTAGCTGCTGAAATTGATGAAAGCAAAGTTCCAGTGCTTCCAATTTTCAAA
  GCCCTTGAAAAATATGGTCAGATTAAACACGAAGAAATGTTTGAAATCTTCAATATGGGT
  GTGGGACTTATGTTGGCGGTCAGCCCTGAAAATGTAGAGCGTGTAAAAGAATTGTTGGAT
  GAAGCAGTCTATGAAATTGGTCGCATCGTCAAGAAAGAAAACGAAAGTGTCATTATCAAA
  TGA
  60
  120
  180
  240
  300
  360
  420
  480
  540
  600
  660
  720
  780
  840
  900
  960
  1020
  1023
  

⊟Protein

⊟General

• locus tag: SPV_RS00265 [old locus tag: SPV_0054 ]
• symbol: PurM
• description: phosphoribosylformylglycinamidine cyclo-ligase
• length: 340
• theoretical pI: 4.45605
• theoretical MW: 36529.8
• GRAVY: 0.0723529

⊟Function

• ⊞⊞reaction:
  EC 6.3.3.1?  ExPASy
  Phosphoribosylformylglycinamidine cyclo-ligase ATP + 2-(formamido)-N¹-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole
• ⊞⊞TIGRFAM:
  Metabolism Purines, pyrimidines, nucleosides, and nucleotides Purine ribonucleotide biosynthesis phosphoribosylformylglycinamidine cyclo-ligase (TIGR00878; EC 6.3.3.1; HMM-score: 451.5)
  and 9 more
  Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Thiamine thiamine-phosphate kinase (TIGR01379; EC 2.7.4.16; HMM-score: 51.1)
  selenide, water dikinase (TIGR00476; EC 2.7.9.3; HMM-score: 37.5)
  hydrogenase expression/formation protein HypE (TIGR02124; HMM-score: 30.4)
  Metabolism Energy metabolism Methanogenesis putative methanogenesis marker protein 2 (TIGR03267; HMM-score: 29.4)
  Metabolism Purines, pyrimidines, nucleosides, and nucleotides Purine ribonucleotide biosynthesis phosphoribosylformylglycinamidine synthase II (TIGR01736; EC 6.3.5.3; HMM-score: 21.2)
  Unknown function Enzymes of unknown specificity AIR synthase-related protein, MSMEG_0567 C-terminal family (TIGR04050; HMM-score: 16.3)
  Unknown function Enzymes of unknown specificity AIR synthase-related protein, sll0787 family (TIGR04049; HMM-score: 14.8)
  Genetic information processing Protein synthesis Other ribosome-associated GTPase EngA (TIGR03594; HMM-score: 12.8)
  phosphonate utilization associated transcriptional regulator (TIGR03338; HMM-score: 12.3)
• TheSEED: data available for D39, Hungary19A-6, TIGR4
• ⊞⊞PFAM:
  no clan defined AIRS_C; AIR synthase related protein, C-terminal domain (PF02769; HMM-score: 127.2)
  and 2 more
  AIRS; AIR synthase related protein, N-terminal domain (PF00586; HMM-score: 75)
  HTH (CL0123) DUF4423; Domain of unknown function (DUF4423) (PF14394; HMM-score: 13)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• ⊞⊞PSORTb: Cytoplasmic
  • Cytoplasmic Score: 9.97
  • Cytoplasmic Membrane Score: 0
  • Cellwall Score: 0.01
  • Extracellular Score: 0.02
  • Internal Helices: 0
• ⊞⊞DeepLocPro: Cytoplasmic
  • Cytoplasmic Score: 0.9863
  • Cytoplasmic Membrane Score: 0.0011
  • Cell wall & surface Score: 0.0001
  • Extracellular Score: 0.0126
• ⊞⊞SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.030712
  • TAT(Tat/SPI): 0.025388
  • LIPO(Sec/SPII): 0.001839
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: WP_000182582 NCBI
• UniProt:

⊟Protein sequence

• MTNKNAYAQSGVDVEAGYEVVERIKKHVARTERAGVMGALGGFGGMFDLSKTGVKEPVLISGTDGVGTKLMLAIKYDKHDTIGQDCVAMCVNDIIAAGAEPLYFLDYVATGKNEPAKLEQVVAGVAEGCVQAGAALIGGETAEMPGMYGEDDYDLAGFAVGVAEKSQIIDGSKVVEGDVLLGLVSSGIHSNGYSLVRRVFADYTGEEVLPELEGKKLKEVLLEPTRIYVKAVLPLIKEELVNGIAHITGGGFIENVPRMFADDLAAEIDESKVPVLPIFKALEKYGQIKHEEMFEIFNMGVGLMLAVSPENVERVKELLDEAVYEIGRIVKKENESVIIK

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator: PurR see SPV_0054

⊟Expression data

• PneumoExpress: SPV_0054 PneumoExpress

⊞Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊞Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications