⊟Summary[edit | edit source]

PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 26-AUG-2017

⊟Summary

• organism: Streptococcus pneumoniae OXC141
locus tag: SPNOXC18200 [new locus tag: SPNOXC_RS10025 ]
pan locus tag^?: PNEUPAN003800000
symbol: SPNOXC18200
pan gene symbol^?: gph_3
• synonym:
• product: putative haloacid dehalogenase-like hydrolase

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SPNOXC18200 [new locus tag: SPNOXC_RS10025 ]
• symbol: SPNOXC18200
• product: putative haloacid dehalogenase-like hydrolase
• replicon: chromosome
• strand: -
• coordinates: 1846159..1846782
• length: 624
• essential: unknown

⊟Accession numbers

• Location: FQ312027 (1846159..1846782) NCBI
• BioCyc: see SPNOXC_RS10025
• MicrobesOnline:
• PneumoBrowse for strain D39V: SPV_1875 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  
  ATGCAAAAAACAGCTTTTATTTGGGATTTAGACGGGACTTTATTGGACTCTTACGAAGCG
  ATTTTATCAGGGATTGAGGAGACTTTTGCTCAGTTTTCTATTCCTTATGATAAGGAGAAG
  GTGAGAGAGTTTATCTTCAAGTATTCGGTGCAAGATTTGCTTGTGCGGGTGGCAGAAGAT
  AGAAATCTGGATGTTGAGGTGCTAAATCAGGTGCGTGCCCAGAGTCTGGCTGAGAAGAAT
  GCTCAGGTAGTTTTGATGCCAGGTGCGCGTGAGGTGCTAGCTTGGGCAGACGAATCAGGA
  ATTCAGCAGTTTATATATACTCATAAGGGGAACAACGCTTTTACCATTCTCAAGGACTTG
  GGGGTGGAATCCTATTTTACAGAGATTTTAACCAGTCAGAGTGGCTTTGTGCGGAAGCCA
  AGTCCAGAAGCGGCTACCTATCTGCTAGATAAGTATCAGTTGAATTCTGATAATACTTAT
  TATATAGGGGATCGGACTCTGGATGTGGAATTTGCCCAGAATAGTGGGATTCAAAGTATC
  AACTTTTTAGAGTCTACTTATGAAGGGAATCACAGGATTCAAGCGTTAGCAGATATTTCC
  CGTATTTTTGAGGCTGAACGATAA
  60
  120
  180
  240
  300
  360
  420
  480
  540
  600
  624
  

⊟Protein

⊟General

• locus tag: SPNOXC18200 [new locus tag: SPNOXC_RS10025 ]
• symbol: SPNOXC18200
• description: putative haloacid dehalogenase-like hydrolase
• length: 207
• theoretical pI: 4.30619
• theoretical MW: 23617.2
• GRAVY: -0.279227

⊟Function

• ⊞⊞TIGRFAM:
  Metabolism Energy metabolism Sugars phosphoglycolate phosphatase, bacterial (TIGR01449; EC 3.1.3.18; HMM-score: 50.8)
  HAD hydrolase, TIGR02253 family (TIGR02253; HMM-score: 50)
  Unknown function Enzymes of unknown specificity HAD hydrolase, family IA, variant 1 (TIGR01549; HMM-score: 45.3)
  noncanonical pyrimidine nucleotidase, YjjG family (TIGR02254; EC 3.1.3.5; HMM-score: 44.7)
  beta-phosphoglucomutase family hydrolase (TIGR02009; HMM-score: 43.4)
  and 18 more
  HAD hydrolase, REG-2-like, family IA (TIGR02252; HMM-score: 39.3)
  Unknown function Enzymes of unknown specificity HAD hydrolase, family IIIA (TIGR01662; HMM-score: 37.7)
  AHBA synthesis associated protein (TIGR01454; HMM-score: 36.5)
  Metabolism Energy metabolism Biosynthesis and degradation of polysaccharides beta-phosphoglucomutase (TIGR01990; EC 5.4.2.6; HMM-score: 32.1)
  Unknown function Enzymes of unknown specificity HAD hydrolase, family IA, variant 3 (TIGR01509; HMM-score: 25.8)
  Metabolism Amino acid biosynthesis Histidine family histidinol-phosphatase (TIGR01261; EC 3.1.3.15; HMM-score: 25.5)
  Unknown function Enzymes of unknown specificity HAD hydrolase, family IIA (TIGR01460; HMM-score: 24.3)
  histidinol-phosphate phosphatase domain (TIGR01656; HMM-score: 24.2)
  Unknown function Enzymes of unknown specificity Cof-like hydrolase (TIGR00099; HMM-score: 21.1)
  phosphonatase-like hydrolase (TIGR03351; HMM-score: 21)
  pyrimidine 5'-nucleotidase (TIGR01993; EC 3.1.3.5; HMM-score: 20.9)
  haloacid dehalogenase, type II (TIGR01428; EC 3.8.1.2; HMM-score: 20.3)
  phosphoglycolate/pyridoxal phosphate phosphatase family (TIGR01452; EC 3.1.3.18; HMM-score: 19.6)
  DNA 3'-phosphatase (TIGR01664; EC 3.1.3.32; HMM-score: 18)
  Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family (TIGR01670; EC 3.1.3.45; HMM-score: 17.6)
  Unknown function Enzymes of unknown specificity HAD phosphoserine phosphatase-like hydrolase, family IB (TIGR01488; HMM-score: 16.6)
  epoxide hydrolase N-terminal domain-like phosphatase (TIGR02247; HMM-score: 13.5)
  Unknown function Enzymes of unknown specificity HAD hydrolase, family IIB (TIGR01484; HMM-score: 12.6)
• TheSEED  :
  • hydrolase, haloacid dehalogenase-like family
• ⊞⊞PFAM:
  HAD (CL0137) HAD_2; haloacid dehalogenase-like hydrolase (PF13419; HMM-score: 102.5)
  and 8 more
  Hydrolase; haloacid dehalogenase-like hydrolase (PF00702; HMM-score: 46.2)
  HAD; haloacid dehalogenase-like hydrolase (PF12710; HMM-score: 41.6)
  Hydrolase_like; HAD-hyrolase-like (PF13242; HMM-score: 32.8)
  Hydrolase_3; haloacid dehalogenase-like hydrolase (PF08282; HMM-score: 23.2)
  PNK3P; Polynucleotide kinase 3 phosphatase (PF08645; HMM-score: 16.6)
  S6PP; Sucrose-6F-phosphate phosphohydrolase (PF05116; HMM-score: 16.5)
  Hydrolase_6; haloacid dehalogenase-like hydrolase (PF13344; HMM-score: 15)
  no clan defined DUF2789; Protein of unknown function (DUF2789) (PF10982; HMM-score: 12.7)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• ⊞⊞PSORTb: unknown (no significant prediction)
  • Cytoplasmic Score: 2.5
  • Cytoplasmic Membrane Score: 2.5
  • Cellwall Score: 2.5
  • Extracellular Score: 2.5
  • Internal Helices: 0
• ⊞⊞SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.00206
  • TAT(Tat/SPI): 0.000132
  • LIPO(Sec/SPII): 0.00029
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: CBW33471 NCBI
• UniProt:

⊟Protein sequence

• MQKTAFIWDLDGTLLDSYEAILSGIEETFAQFSIPYDKEKVREFIFKYSVQDLLVRVAEDRNLDVEVLNQVRAQSLAEKNAQVVLMPGAREVLAWADESGIQQFIYTHKGNNAFTILKDLGVESYFTEILTSQSGFVRKPSPEAATYLLDKYQLNSDNTYYIGDRTLDVEFAQNSGIQSINFLESTYEGNHRIQALADISRIFEAER

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator:

⊟Expression data

• PneumoExpress for strain D39V: SPV_1875 PneumoExpress

⊞Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊞Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications