⊟Summary[edit | edit source]

PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 25-OCT-2019

⊟Summary

• organism: Streptococcus pneumoniae NU83127
locus tag: SPNU_0202 [new locus tag: EL277_RS01100 ]
pan locus tag^?: PNEUPAN000942000
symbol: udk_1
pan gene symbol^?: udk_1
• synonym:
• product: Uridine kinase

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SPNU_0202 [new locus tag: EL277_RS01100 ]
• symbol: udk_1
• product: Uridine kinase
• replicon: chromosome
• strand: +
• coordinates: 202846..203463
• length: 618
• essential: unknown

⊟Accession numbers

• Location: AP018936 (202846..203463) NCBI
• BioCyc: see EL277_RS01100
• MicrobesOnline:
• PneumoBrowse for strain D39V: SPV_0191 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
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  241
  301
  361
  421
  481
  541
  601
  
  ATGAAGAAAAAGGACTTAGTAGACCAACTAGTCTCAGAGATCGAGACGGGGAAAGTCAGG
  ACACTGGGAATATACGGTCATGGAGCTTCAGGTAAATCAACCTTTGCACAGGAATTGTAC
  CAAGCTTTAGATTCTACTACAGTAAATTTGCTAGAGACAGATCCTTATATCACCTCAGGA
  CGCCATCTGGTAGTACCCAAGGACGCGCCGAATCAAAAGGTGACAGCCAGTCTGCCAGTG
  GCGCATGAACTGGAGAGTTTGCAGAGAGATATCCTTGCCTTGCAGGCGGGTATGGATGTC
  TTGACAATTGAAGAACCTTGGAAGGCTAGTGAGGTCTTGTCTGGAGCCAAACCAATTTTG
  ATTGTCGAAGGGATGTCTGTTGGCTTTCTACCCAAGGAACTCTTTGAAAAAACCATCTGT
  TTCTACACGGATGAGGAGACCGAATTAAAGCGACGCCTTGCTAGAGATACGACTGTGAGA
  AATCGCGATGCATCCTTTATATTGGCTAGCCATCAGATGAGACGGGAGCAGTATCTGCGA
  TACTATAAAGAAACTGAGTCTAAGGCGGATATCTTAGTGGACCAATCAGAAGATAAATTT
  GATGTCAAGAGGACTTAA
  60
  120
  180
  240
  300
  360
  420
  480
  540
  600
  618
  

⊟Protein

⊟General

• locus tag: SPNU_0202 [new locus tag: EL277_RS01100 ]
• symbol: Udk_1
• description: Uridine kinase
• length: 205
• theoretical pI: 5.41554
• theoretical MW: 23194.2
• GRAVY: -0.423415

⊟Function

• ⊞⊞TIGRFAM:
  Metabolism Purines, pyrimidines, nucleosides, and nucleotides Salvage of nucleosides and nucleotides uridine kinase (TIGR00235; EC 2.7.1.48; HMM-score: 48.9)
  and 9 more
  arsenical pump-driving ATPase (TIGR04291; EC 3.6.1.-; HMM-score: 13.1)
  Metabolism Transport and binding proteins Unknown substrate energy-coupling factor transporter ATPase (TIGR04521; EC 3.6.3.-; HMM-score: 13.1)
  Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Pantothenate and coenzyme A dephospho-CoA kinase (TIGR00152; EC 2.7.1.24; HMM-score: 12.9)
  Metabolism Central intermediary metabolism Nitrogen fixation nitrogenase iron protein (TIGR01287; EC 1.18.6.1; HMM-score: 12.3)
  Metabolism Transport and binding proteins Amino acids, peptides and amines LAO/AO transport system ATPase (TIGR00750; EC 2.7.-.-; HMM-score: 11.7)
  Signal transduction Regulatory functions Protein interactions LAO/AO transport system ATPase (TIGR00750; EC 2.7.-.-; HMM-score: 11.7)
  Metabolism Transport and binding proteins Unknown substrate energy-coupling factor transporter ATPase (TIGR04520; EC 3.6.3.-; HMM-score: 11.5)
  Genetic information processing DNA metabolism DNA replication, recombination, and repair phage/plasmid primase, P4 family, C-terminal domain (TIGR01613; HMM-score: 11.4)
  Genetic information processing Mobile and extrachromosomal element functions Prophage functions phage/plasmid primase, P4 family, C-terminal domain (TIGR01613; HMM-score: 11.4)
• TheSEED: data available for D39, Hungary19A-6
• ⊞⊞PFAM:
  P-loop_NTPase (CL0023) PRK; Phosphoribulokinase / Uridine kinase family (PF00485; HMM-score: 47.5)
  and 12 more
  AAA_18; AAA domain (PF13238; HMM-score: 21)
  AAA_16; AAA ATPase domain (PF13191; HMM-score: 20.9)
  AAA_33; AAA domain (PF13671; HMM-score: 19.9)
  AAA_17; AAA domain (PF13207; HMM-score: 16.3)
  CoaE; Dephospho-CoA kinase (PF01121; HMM-score: 15.7)
  Thymidylate_kin; Thymidylate kinase (PF02223; HMM-score: 15.6)
  NB-ARC; NB-ARC domain (PF00931; HMM-score: 13.8)
  no clan defined Sortase; Sortase domain (PF04203; HMM-score: 13)
  P-loop_NTPase (CL0023) KTI12; Chromatin associated protein KTI12 (PF08433; HMM-score: 12.6)
  ATP_bind_1; Conserved hypothetical ATP binding protein (PF03029; HMM-score: 12.2)
  MeaB; Methylmalonyl Co-A mutase-associated GTPase MeaB (PF03308; HMM-score: 12)
  Fer4_NifH; 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family (PF00142; HMM-score: 11.4)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• ⊞⊞PSORTb: Cytoplasmic
  • Cytoplasmic Score: 7.5
  • Cytoplasmic Membrane Score: 1.15
  • Cellwall Score: 0.62
  • Extracellular Score: 0.73
  • Internal Helices: 0
• ⊞⊞SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.030744
  • TAT(Tat/SPI): 0.008226
  • LIPO(Sec/SPII): 0.003368
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: BBG34093 NCBI
• UniProt:

⊟Protein sequence

• MKKKDLVDQLVSEIETGKVRTLGIYGHGASGKSTFAQELYQALDSTTVNLLETDPYITSGRHLVVPKDAPNQKVTASLPVAHELESLQRDILALQAGMDVLTIEEPWKASEVLSGAKPILIVEGMSVGFLPKELFEKTICFYTDEETELKRRLARDTTVRNRDASFILASHQMRREQYLRYYKETESKADILVDQSEDKFDVKRT

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• data available for D39

⊟Expression data

• PneumoExpress for strain D39V: SPV_0191 PneumoExpress

⊞Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊞Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications