⊟Summary[edit | edit source]

PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 17-JAN-2018

⊟Summary

• organism: Streptococcus pneumoniae AP200
locus tag: SPAP_2169 [new locus tag: SPAP_RS10725 ]
pan locus tag^?: PNEUPAN003702000
symbol: SPAP_2169
pan gene symbol^?: —
• synonym:
• product: Predicted transcriptional regulator

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SPAP_2169 [new locus tag: SPAP_RS10725 ]
• symbol: SPAP_2169
• product: Predicted transcriptional regulator
• replicon: chromosome
• strand: -
• coordinates: 2007609..2007815
• length: 207
• essential: unknown

⊟Accession numbers

• Location: CP002121 (2007609..2007815) NCBI
• BioCyc: see SPAP_RS10725
• MicrobesOnline:
• PneumoBrowse for strain D39V: SPV_1947 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  
  ATGCAACTAAAAAATCGTCTAAAAGAGCTTCGAGCTCGCGATGGTCTCAATCAAACCGAC
  CTAGCCAAACTGGCAGGGGTTTCCAGACAGACCATTAGCCTACTAGAACGGGATGAGTAC
  ACCCCATCCATTATCATTGCCCTGAAAATATCTCAAATTTTCAACGAAACAGTCGAATCG
  GTATTTCGTTTGGAGGAGGACGAGTGA
  60
  120
  180
  207
  

⊟Protein

⊟General

• locus tag: SPAP_2169 [new locus tag: SPAP_RS10725 ]
• symbol: SPAP_2169
• description: Predicted transcriptional regulator
• length: 68
• theoretical pI: 4.75628
• theoretical MW: 7847.91
• GRAVY: -0.401471

⊟Function

• ⊞⊞TIGRFAM:
  Signal transduction Regulatory functions DNA interactions transcriptional regulator, y4mF family (TIGR03070; HMM-score: 41.3)
  and 6 more
  putative zinc finger/helix-turn-helix protein, YgiT family (TIGR03830; HMM-score: 22.7)
  Genetic information processing Mobile and extrachromosomal element functions Other addiction module antidote protein, HigA family (TIGR02607; HMM-score: 18.9)
  Signal transduction Regulatory functions DNA interactions addiction module antidote protein, HigA family (TIGR02607; HMM-score: 18.9)
  Signal transduction Regulatory functions Protein interactions addiction module antidote protein, HigA family (TIGR02607; HMM-score: 18.9)
  Signal transduction Regulatory functions DNA interactions DNA-binding protein, Tfx family (TIGR00721; HMM-score: 17.4)
  Unknown function General mobile mystery protein A (TIGR02612; HMM-score: 16.1)
• TheSEED  :
  • transcriptional regulator, Cro/CI family
• ⊞⊞PFAM:
  HTH (CL0123) HTH_3; Helix-turn-helix (PF01381; HMM-score: 53.1)
  and 19 more
  HTH_19; Helix-turn-helix domain (PF12844; HMM-score: 36.9)
  HTH_31; Helix-turn-helix domain (PF13560; HMM-score: 35)
  HTH_26; Cro/C1-type HTH DNA-binding domain (PF13443; HMM-score: 26.2)
  LacI; Bacterial regulatory proteins, lacI family (PF00356; HMM-score: 20.1)
  MarR_2; MarR family (PF12802; HMM-score: 18.4)
  HTH_24; Winged helix-turn-helix DNA-binding (PF13412; HMM-score: 17.4)
  HTH_23; Homeodomain-like domain (PF13384; HMM-score: 16.4)
  HTH_Crp_2; Crp-like helix-turn-helix domain (PF13545; HMM-score: 15.9)
  HTH_25; Helix-turn-helix domain (PF13413; HMM-score: 15.4)
  Phage_CI_repr; Bacteriophage CI repressor helix-turn-helix domain (PF07022; HMM-score: 15)
  MarR; MarR family (PF01047; HMM-score: 14.9)
  Sigma70_r4; Sigma-70, region 4 (PF04545; HMM-score: 14.9)
  HTH_28; Helix-turn-helix domain (PF13518; HMM-score: 14.9)
  HTH_11; HTH domain (PF08279; HMM-score: 14.5)
  no clan defined DUF211; Uncharacterized ArCR, COG1888 (PF02680; HMM-score: 14.1)
  HTH (CL0123) HTH_38; Helix-turn-helix domain (PF13936; HMM-score: 13.9)
  HTH_37; Helix-turn-helix domain (PF13744; HMM-score: 13.8)
  HTH_7; Helix-turn-helix domain of resolvase (PF02796; HMM-score: 13.6)
  no clan defined TnsD; Tn7-like transposition protein D (PF15978; HMM-score: 12.2)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• ⊞⊞PSORTb: Cytoplasmic
  • Cytoplasmic Score: 7.5
  • Cytoplasmic Membrane Score: 1.15
  • Cellwall Score: 0.62
  • Extracellular Score: 0.73
  • Internal Helices: 0
• ⊞⊞SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.001278
  • TAT(Tat/SPI): 0.000304
  • LIPO(Sec/SPII): 0.000308
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: ADM85700 NCBI
• UniProt:

⊟Protein sequence

• MQLKNRLKELRARDGLNQTDLAKLAGVSRQTISLLERDEYTPSIIIALKISQIFNETVESVFRLEEDE

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator:

⊟Expression data

• PneumoExpress for strain D39V: SPV_1947 PneumoExpress

⊞Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊞Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications