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serotype 1

NCBI: 26-OCT-2021

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae R6
  • locus tag: SPR_RS04410 [old locus tag: spr0880 ]
  • pan locus tag?: PNEUPAN002004000
  • symbol: tehB
  • pan gene symbol?: tehB
  • synonym:
  • product: SAM-dependent methyltransferase TehB

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPR_RS04410 [old locus tag: spr0880 ]
  • symbol: tehB
  • product: SAM-dependent methyltransferase TehB
  • replicon: chromosome
  • strand: +
  • coordinates: 870734..871594
  • length: 861
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    ATGGAAAAATTAGTTGCCTATAAACGCATGCCTTTGTGGAATAAACAAACAATGCCTGAA
    GCTGTTCAGCAAAAGCACAATACAAAAGTTGGGACTTGGGGGAAAATTACTGTCTTGAAG
    GGAGCTCTCAAGTTTATTGAATTGACAGAAGAAGGGGAAGTTCTAGCTGAACACCTCTTT
    GAAGCAGGGGCAGACAATCCAATGGCCCAACCTCAAGCCTGGCACCGAGTGGAAGCTGCC
    ACAGATGATGTGGAATGGTACTTGGAATTTTATTGTAAACCTGAGGATTATTTTGCTAAA
    AAATACAATACCAATCCTGTTCATTCAGAGGTCCTAGAGGCCATGCAGACAGTGAAACAA
    GGGAAAGCTTTGGATTTGGGTTGTGGTCAGGGGCGTAATTCTCTTTTTCTAGCCCAGCAA
    GATTTTGATGTGACGGCTGTAGATCAAAATGGACTAGCTCTTGAAATCTTGCAAAGCATT
    GTGGAGCAGGAAGATTTGGACATGCCTGTTGGCCTTTACGATATCAATTCAGCTAGCATT
    GAACAAGAATATGATTTTATCGTTTCAACAGTTGTTCTCATGTTTCTACAAGCGGACCGC
    ATTCCAGCTATTATTCAAAATATGCAGGAGAAAACCAGTGTTGGTGGTTACAACCTTATC
    GTTTGTGCCATGGACACGGAGGATTATCCTTGCTCGGTTAACTTCCCATTCACCTTTAAA
    GAAGGAGAACTGGCAGACTATTACAAGGATTGGGAATTGGTTAAGTACAATGAAAATCCA
    GGCCATTTGCACCGTCGCGATGAGAATGGCAATCGTATTCAACTACGCTTTGCGACCTTA
    CTAGCTAAGAAAATCAAGTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    861

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPR_RS04410 [old locus tag: spr0880 ]
  • symbol: TehB
  • description: SAM-dependent methyltransferase TehB
  • length: 286
  • theoretical pI: 4.55746
  • theoretical MW: 32684.9
  • GRAVY: -0.39021

⊟Function[edit | edit source]

  • reaction:
    EC 2.1.1.-?  ExPASy
  • ⊞TIGRFAM:
    Cellular processes Cellular processes Toxin production and resistance tellurite resistance protein TehB (TIGR00477; HMM-score: 360.5)
    and 12 more
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Chlorophyll and bacteriochlorphyll magnesium protoporphyrin O-methyltransferase (TIGR02021; EC 2.1.1.11; HMM-score: 28.6)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Glutathione and analogs putative 4-mercaptohistidine N1-methyltranferase (TIGR04345; HMM-score: 26.5)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Menaquinone and ubiquinone 3-demethylubiquinone-9 3-O-methyltransferase (TIGR01983; EC 2.1.1.64; HMM-score: 25.6)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Biotin malonyl-acyl carrier protein O-methyltransferase BioC (TIGR02072; EC 2.1.1.-; HMM-score: 24.9)
    Genetic information processing Protein fate Protein modification and repair protein-(glutamine-N5) methyltransferase, release factor-specific (TIGR03534; EC 2.1.1.-; HMM-score: 23.2)
    Genetic information processing Protein synthesis Ribosomal proteins: synthesis and modification ribosomal protein L11 methyltransferase (TIGR00406; EC 2.1.1.-; HMM-score: 17.8)
    Genetic information processing Protein fate Protein modification and repair methyltransferase, HemK family (TIGR00536; HMM-score: 16.2)
    pseudaminic acid biosynthesis-associated methylase (TIGR03587; HMM-score: 15.3)
    Genetic information processing Protein synthesis tRNA and rRNA base modification 23S rRNA (uracil-5-)-methyltransferase RumA (TIGR00479; EC 2.1.1.-; HMM-score: 14.4)
    cupin fold metalloprotein, WbuC family (TIGR04366; HMM-score: 14)
    Genetic information processing Transcription RNA processing 3' terminal RNA ribose 2'-O-methyltransferase Hen1 (TIGR04074; EC 2.1.1.-; HMM-score: 11.1)
    Genetic information processing Protein synthesis tRNA and rRNA base modification 3' terminal RNA ribose 2'-O-methyltransferase Hen1 (TIGR04074; EC 2.1.1.-; HMM-score: 11.1)
  • TheSEED: see spr0880
  • ⊞PFAM:
    NADP_Rossmann (CL0063) TehB; Tellurite resistance protein TehB (PF03848; HMM-score: 308)
    and 14 more
    Cupin (CL0029) DUF1971; Domain of unknown function (DUF1971) (PF09313; HMM-score: 97.6)
    NADP_Rossmann (CL0063) Methyltransf_25; Methyltransferase domain (PF13649; HMM-score: 40.7)
    Methyltransf_23; Methyltransferase domain (PF13489; HMM-score: 37.7)
    MTS; Methyltransferase small domain (PF05175; HMM-score: 37.2)
    Methyltransf_31; Methyltransferase domain (PF13847; HMM-score: 35.8)
    Methyltransf_11; Methyltransferase domain (PF08241; HMM-score: 30.3)
    Methyltransf_12; Methyltransferase domain (PF08242; HMM-score: 25)
    NodS; Nodulation protein S (NodS) (PF05401; HMM-score: 20)
    CMAS; Mycolic acid cyclopropane synthetase (PF02353; HMM-score: 17.9)
    no clan defined TRIC; TRIC channel (PF05197; HMM-score: 17.3)
    NADP_Rossmann (CL0063) TPMT; Thiopurine S-methyltransferase (TPMT) (PF05724; HMM-score: 13.4)
    PRMT5; PRMT5 arginine-N-methyltransferase (PF05185; HMM-score: 12.7)
    Methyltransf_8; Hypothetical methyltransferase (PF05148; HMM-score: 12.4)
    CheR; CheR methyltransferase, SAM binding domain (PF01739; HMM-score: 11.9)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • ⊞PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • ⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.00556
    • TAT(Tat/SPI): 0.000203
    • LIPO(Sec/SPII): 0.000368
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MEKLVAYKRMPLWNKQTMPEAVQQKHNTKVGTWGKITVLKGALKFIELTEEGEVLAEHLFEAGADNPMAQPQAWHRVEAATDDVEWYLEFYCKPEDYFAKKYNTNPVHSEVLEAMQTVKQGKALDLGCGQGRNSLFLAQQDFDVTAVDQNGLALEILQSIVEQEDLDMPVGLYDINSASIEQEYDFIVSTVVLMFLQADRIPAIIQNMQEKTSVGGYNLIVCAMDTEDYPCSVNFPFTFKEGELADYYKDWELVKYNENPGHLHRRDENGNRIQLRFATLLAKKIK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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