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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 13-DEC-2020

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae SPN994038
  • locus tag: SPN994038_RS04690 [old locus tag: SPN994038_08660 ]
  • pan locus tag?: PNEUPAN002004000
  • symbol: tehB
  • pan gene symbol?: tehB
  • synonym:
  • product: SAM-dependent methyltransferase TehB

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPN994038_RS04690 [old locus tag: SPN994038_08660 ]
  • symbol: tehB
  • product: SAM-dependent methyltransferase TehB
  • replicon: chromosome
  • strand: +
  • coordinates: 878035..878895
  • length: 861
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_021026 (878035..878895) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0864 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    ATGGAAAAATTAGTTGCCTATAAACGCATGCCTTTGTGGAATAAACAAACAATGCCTGAA
    GCTGTTCAGCAAAAGCACAATACAAAAGTTGGGACTTGGGGGAAAATTACTGTCTTGAAG
    GGAGCTCTCAAGTTTATTGAATTGACAGAAGAAGGGGAAGTTCTAGCTGAACACCTCTTT
    GAAGCAGGGGCAGACAATCCAATGGCCCAACCTCAAGCCTGGCACCGAGTGGAAGCTGCC
    ACAGATGATGTGGAATGGTACTTGGAATTTTATTGTAAACCTGAGGATTATTTTGCTAAA
    AAATACAATACCAATCCTGTTCATTCAGAGGTCCTAGAGGTCATGGAGACAGTGAAACAA
    GGGAAAGCTTTGGATTTGGGTTGTGGTCAGGGGCGTAATTCTCTTTTTCTAGCCCAGCAA
    GATTTTGATGTGACGGCTGTAGATCAAAATGGACTAGCTCTTGAAATCTTGCAAAGCATT
    GTGGAGCAGGAAGATTTGGACATGCCTGTTGGCCTTTACGATATCAATTCAGCTAGCATT
    GAACAAGAATATGATTTTATCGTTTCAACAGTTGTTCTCATGTTTCTACAAGCGGACCGC
    ATTCCAGCTATTATTCAAAATATGCAGGAGAAAACCAGTGTTGGTGGTTACAACCTTATC
    GTTTGTGCCATGGACACGGAGGATTATCCTTGCTCGGTTAACTTCCCATTCACCTTTAAA
    GAAGGAGAACTGGCAGACTATTACAAGGATTGGGAATTGGTTAAGTACAATGAAAATCCA
    GGCCATTTGCATCGTCGCGATGAGAATGGCAATCGTATTCAACTACGCTTTGCGACCTTA
    CTAGCTAAGAAAATCAAGTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    861

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPN994038_RS04690 [old locus tag: SPN994038_08660 ]
  • symbol: TehB
  • description: SAM-dependent methyltransferase TehB
  • length: 286
  • theoretical pI: 4.51814
  • theoretical MW: 32714
  • GRAVY: -0.381818

⊟Function[edit | edit source]

  • reaction:
    EC 2.1.1.-?  ExPASy
  • TIGRFAM:
    Cellular processes Cellular processes Toxin production and resistance tellurite resistance protein TehB (TIGR00477; HMM-score: 356.6)
    and 10 more
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Chlorophyll and bacteriochlorphyll magnesium protoporphyrin O-methyltransferase (TIGR02021; EC 2.1.1.11; HMM-score: 28.2)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Glutathione and analogs putative 4-mercaptohistidine N1-methyltranferase (TIGR04345; HMM-score: 25.9)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Menaquinone and ubiquinone 3-demethylubiquinone-9 3-O-methyltransferase (TIGR01983; EC 2.1.1.64; HMM-score: 25.1)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Biotin malonyl-acyl carrier protein O-methyltransferase BioC (TIGR02072; EC 2.1.1.-; HMM-score: 24.1)
    Genetic information processing Protein fate Protein modification and repair protein-(glutamine-N5) methyltransferase, release factor-specific (TIGR03534; EC 2.1.1.-; HMM-score: 22.5)
    Genetic information processing Protein synthesis Ribosomal proteins: synthesis and modification ribosomal protein L11 methyltransferase (TIGR00406; EC 2.1.1.-; HMM-score: 17.4)
    Genetic information processing Protein fate Protein modification and repair methyltransferase, HemK family (TIGR00536; HMM-score: 15.5)
    pseudaminic acid biosynthesis-associated methylase (TIGR03587; HMM-score: 14.9)
    cupin fold metalloprotein, WbuC family (TIGR04366; HMM-score: 14)
    Genetic information processing Protein synthesis tRNA and rRNA base modification 23S rRNA (uracil-5-)-methyltransferase RumA (TIGR00479; EC 2.1.1.-; HMM-score: 13.7)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    NADP_Rossmann (CL0063) TehB; Tellurite resistance protein TehB (PF03848; HMM-score: 305.8)
    and 13 more
    Cupin (CL0029) DUF1971; Domain of unknown function (DUF1971) (PF09313; HMM-score: 97.8)
    NADP_Rossmann (CL0063) Methyltransf_25; Methyltransferase domain (PF13649; HMM-score: 40.7)
    Methyltransf_23; Methyltransferase domain (PF13489; HMM-score: 37.6)
    MTS; Methyltransferase small domain (PF05175; HMM-score: 36.6)
    Methyltransf_31; Methyltransferase domain (PF13847; HMM-score: 35.8)
    Methyltransf_11; Methyltransferase domain (PF08241; HMM-score: 30.3)
    Methyltransf_12; Methyltransferase domain (PF08242; HMM-score: 25)
    NodS; Nodulation protein S (NodS) (PF05401; HMM-score: 19.9)
    CMAS; Mycolic acid cyclopropane synthetase (PF02353; HMM-score: 17.7)
    no clan defined TRIC; TRIC channel (PF05197; HMM-score: 17)
    NADP_Rossmann (CL0063) Methyltransf_8; Hypothetical methyltransferase (PF05148; HMM-score: 12.8)
    PRMT5; PRMT5 arginine-N-methyltransferase (PF05185; HMM-score: 12.7)
    MetW; Methionine biosynthesis protein MetW (PF07021; HMM-score: 12.2)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.00556
    • TAT(Tat/SPI): 0.000203
    • LIPO(Sec/SPII): 0.000368
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000413769 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MEKLVAYKRMPLWNKQTMPEAVQQKHNTKVGTWGKITVLKGALKFIELTEEGEVLAEHLFEAGADNPMAQPQAWHRVEAATDDVEWYLEFYCKPEDYFAKKYNTNPVHSEVLEVMETVKQGKALDLGCGQGRNSLFLAQQDFDVTAVDQNGLALEILQSIVEQEDLDMPVGLYDINSASIEQEYDFIVSTVVLMFLQADRIPAIIQNMQEKTSVGGYNLIVCAMDTEDYPCSVNFPFTFKEGELADYYKDWELVKYNENPGHLHRRDENGNRIQLRFATLLAKKIK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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