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From PneumoWiki
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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 30-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae R6
  • locus tag: spr1109 [new locus tag: SPR_RS05535 ]
  • pan locus tag?: PNEUPAN002497000
  • symbol: fhs
  • pan gene symbol?: fhs
  • synonym:
  • product: Formate--tetrahydrofolate ligase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: spr1109 [new locus tag: SPR_RS05535 ]
  • symbol: fhs
  • product: Formate--tetrahydrofolate ligase
  • replicon: chromosome
  • strand: -
  • coordinates: 1109867..1111537
  • length: 1671
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    ATGAAAACAGATATTGAAATCGCACAGAGTATTGAGTTGAAGCCAATTGTTGATGTTGTA
    GAGAAACTTGGTATTTCTTACGACGATTTGGAGTTGTACGGAAAGTACAAGGCTAAACTC
    AGCTTTGATAAAATTCGTGCAGTTGAGAGCAATCCAGTCGGTAAATTGATCTTGGTTACT
    GCCATCAACCCAACACCTGCAGGTGAAGGAAAGTCGACGCTTACCATTGGTCTTGCGGAT
    GCCTTGAACAAGATTGGCAAGAAAACCATGATTGCTATCCGCGAACCGTCTCTTGGTCCA
    GTCATGGGGATCAAGGGTGGTGCTGCTGGTGGTGGGTATGCACAAGTTCTGCCAATGGAA
    GACATCAACCTCCACTTTACTGGAGATATGCATGCTATTACAACTGCCAACAATGCCCTT
    TCTGCCTTGATTGACAACCACTTGCACCAAGGGAATGAGCTGGGAATTGATCAACGTCGT
    ATCCTCTGGAAACGCGTTGTGGACTTGAACGACCGTGCGCTCCGCCATGTGACTGTTGGT
    CTTGGTGGTCCTCTAAACGGTATTCCACGTGAGGACGGTTTTGATATTACAGTTGCTTCA
    GAAATCATGGCAATTCTTTGCTTGGCAACGGACATCGAGGACTTGAAACGTCGTTTGGCG
    AATATCGTTATTGGTTATCGCTATGACCGTACGCCTGTTTCTGTAGGTGATTTGCAGGTT
    GAGGGTGCCTTGGCTTTGATTTTGAAGGATGCTATTAAGCCAAACTTGGTTCAGACAATT
    TACGGTACACCTGCCTTTGTACACGGTGGTCCATTTGCCAATATTGCTCATGGCTGTAAC
    TCTGTTTTGGCGACGACAACAGCCCTTCACTTGGCTGATTACACTGTTACTGAAGCTGGT
    TTTGGTGCGGACCTTGGTGCTGAGAAATTCCTTGATATCAAGACACCAAACTTGCCAACA
    TCTCCAGATGCAGTTGTTATTGTCGCAACCCTTCGTGCCCTTAAGATGAATGGTGGTGTG
    GCTAAAGACGCTCTGACTGAAGAAAATGTAGAGGCAGTTCGTGCAGGTTTTGCTAACTTG
    AAACGCCACGTTGAAAATATCCGTAAGTTCGGTATTCCAGCAGTTGTAGCTATTAACGAA
    TTTGTATCTGATACAGAAGCTGAAATTGCAGTCTTAAAAGAACTCTGTGCCTCAATCGAT
    GTACCAGTTGAATTGGCTAGTGTCTGGGCTGATGGAGCAGAAGGTGGAGTAGCACTTGCC
    GAAACAGTTGTTAAGACAATTGCTGAAAATCCAGCTAACTATAAACGTTTGTATGATAAT
    GACCTTTCTGTCCAAGAAAAGATTGAAAAAATTGTCACTGAAATCTATCGTGGTAGCAAA
    GTGAACTTTGAGAAGAAATCTCAAACACAAATTGCTCAAATCGTTCAAAACGGTTGGGAC
    AAATTGCCAATCTGTATGGCTAAAACTCAATACAGTTTCTCAGATAATCCAAATGCGCTT
    GGAGCACCAGAAAACTTTGAAATTACCATTCGTGAATTGGTACCAAAATTAGGTGCAGGC
    TTCATCGTTGCCTTAACTGGTGATGTTATGACCATGCCAGGTCTTCCAAAACGTCCAGCA
    GCTCTCAACATGGATGTTGAAAGCGATGGAACTGTACTAGGCTTGTTCTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1671

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: spr1109 [new locus tag: SPR_RS05535 ]
  • symbol: Fhs
  • description: Formate--tetrahydrofolate ligase
  • length: 556
  • theoretical pI: 5.09027
  • theoretical MW: 59629.3
  • GRAVY: 0.069964

⊟Function[edit | edit source]

  • ⊞⊞reaction:
    EC 6.3.4.3?  ExPASy
    Formate--tetrahydrofolate ligase ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate
  • TIGRFAM:
  • ⊞⊞TheSEED  :
    • Formate--tetrahydrofolate ligase (EC 6.3.4.3)
    Carbohydrates One-carbon Metabolism One-carbon metabolism by tetrahydropterines  Formate--tetrahydrofolate ligase (EC 6.3.4.3)
    and 3 more
    Carbohydrates One-carbon Metabolism Serine-glyoxylate cycle  Formate--tetrahydrofolate ligase (EC 6.3.4.3)
    Cofactors, Vitamins, Prosthetic Groups, Pigments Folate and pterines Folate Biosynthesis  Formate--tetrahydrofolate ligase (EC 6.3.4.3)
    Miscellaneous Miscellaneous - no subcategory EC 6.3.4.- Ligases that form carbon-nitrogen bonds  Formate--tetrahydrofolate ligase (EC 6.3.4.3)
  • ⊞⊞PFAM:
    P-loop_NTPase (CL0023) FTHFS; Formate--tetrahydrofolate ligase (PF01268; HMM-score: 878.4)
    and 2 more
    CbiA; CobQ/CobB/MinD/ParA nucleotide binding domain (PF01656; HMM-score: 18.4)
    no clan defined DUF719; Protein of unknown function (DUF719) (PF05334; HMM-score: 14)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • ⊞⊞PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • ⊞⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.003959
    • TAT(Tat/SPI): 0.000607
    • LIPO(Sec/SPII): 0.000373
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MKTDIEIAQSIELKPIVDVVEKLGISYDDLELYGKYKAKLSFDKIRAVESNPVGKLILVTAINPTPAGEGKSTLTIGLADALNKIGKKTMIAIREPSLGPVMGIKGGAAGGGYAQVLPMEDINLHFTGDMHAITTANNALSALIDNHLHQGNELGIDQRRILWKRVVDLNDRALRHVTVGLGGPLNGIPREDGFDITVASEIMAILCLATDIEDLKRRLANIVIGYRYDRTPVSVGDLQVEGALALILKDAIKPNLVQTIYGTPAFVHGGPFANIAHGCNSVLATTTALHLADYTVTEAGFGADLGAEKFLDIKTPNLPTSPDAVVIVATLRALKMNGGVAKDALTEENVEAVRAGFANLKRHVENIRKFGIPAVVAINEFVSDTEAEIAVLKELCASIDVPVELASVWADGAEGGVALAETVVKTIAENPANYKRLYDNDLSVQEKIEKIVTEIYRGSKVNFEKKSQTQIAQIVQNGWDKLPICMAKTQYSFSDNPNALGAPENFEITIRELVPKLGAGFIVALTGDVMTMPGLPKRPAALNMDVESDGTVLGLF

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • ⊞⊞regulators: MtaR* (repression) regulon, PurR (repression) regulon

⊟Expression data[edit | edit source]

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Retrieved from "http://pneumowiki.med.uni-greifswald.de/index.php?title=spr1109&oldid=129767"
Insert paragraph

NCBI: 30-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae R6
  • locus tag: spr1109 [new locus tag: SPR_RS05535 ]
  • pan locus tag?: PNEUPAN002497000
  • symbol: fhs
  • pan gene symbol?: fhs
  • synonym:
  • product: Formate--tetrahydrofolate ligase

Insert paragraph

⊟Genome View[edit | edit source]

Insert paragraph

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: spr1109 [new locus tag: SPR_RS05535 ]
  • symbol: fhs
  • product: Formate--tetrahydrofolate ligase
  • replicon: chromosome
  • strand: -
  • coordinates: 1109867..1111537
  • length: 1671
  • essential: unknown

Insert paragraph

⊟Accession numbers[edit | edit source]

Insert paragraph

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    ATGAAAACAGATATTGAAATCGCACAGAGTATTGAGTTGAAGCCAATTGTTGATGTTGTA
    GAGAAACTTGGTATTTCTTACGACGATTTGGAGTTGTACGGAAAGTACAAGGCTAAACTC
    AGCTTTGATAAAATTCGTGCAGTTGAGAGCAATCCAGTCGGTAAATTGATCTTGGTTACT
    GCCATCAACCCAACACCTGCAGGTGAAGGAAAGTCGACGCTTACCATTGGTCTTGCGGAT
    GCCTTGAACAAGATTGGCAAGAAAACCATGATTGCTATCCGCGAACCGTCTCTTGGTCCA
    GTCATGGGGATCAAGGGTGGTGCTGCTGGTGGTGGGTATGCACAAGTTCTGCCAATGGAA
    GACATCAACCTCCACTTTACTGGAGATATGCATGCTATTACAACTGCCAACAATGCCCTT
    TCTGCCTTGATTGACAACCACTTGCACCAAGGGAATGAGCTGGGAATTGATCAACGTCGT
    ATCCTCTGGAAACGCGTTGTGGACTTGAACGACCGTGCGCTCCGCCATGTGACTGTTGGT
    CTTGGTGGTCCTCTAAACGGTATTCCACGTGAGGACGGTTTTGATATTACAGTTGCTTCA
    GAAATCATGGCAATTCTTTGCTTGGCAACGGACATCGAGGACTTGAAACGTCGTTTGGCG
    AATATCGTTATTGGTTATCGCTATGACCGTACGCCTGTTTCTGTAGGTGATTTGCAGGTT
    GAGGGTGCCTTGGCTTTGATTTTGAAGGATGCTATTAAGCCAAACTTGGTTCAGACAATT
    TACGGTACACCTGCCTTTGTACACGGTGGTCCATTTGCCAATATTGCTCATGGCTGTAAC
    TCTGTTTTGGCGACGACAACAGCCCTTCACTTGGCTGATTACACTGTTACTGAAGCTGGT
    TTTGGTGCGGACCTTGGTGCTGAGAAATTCCTTGATATCAAGACACCAAACTTGCCAACA
    TCTCCAGATGCAGTTGTTATTGTCGCAACCCTTCGTGCCCTTAAGATGAATGGTGGTGTG
    GCTAAAGACGCTCTGACTGAAGAAAATGTAGAGGCAGTTCGTGCAGGTTTTGCTAACTTG
    AAACGCCACGTTGAAAATATCCGTAAGTTCGGTATTCCAGCAGTTGTAGCTATTAACGAA
    TTTGTATCTGATACAGAAGCTGAAATTGCAGTCTTAAAAGAACTCTGTGCCTCAATCGAT
    GTACCAGTTGAATTGGCTAGTGTCTGGGCTGATGGAGCAGAAGGTGGAGTAGCACTTGCC
    GAAACAGTTGTTAAGACAATTGCTGAAAATCCAGCTAACTATAAACGTTTGTATGATAAT
    GACCTTTCTGTCCAAGAAAAGATTGAAAAAATTGTCACTGAAATCTATCGTGGTAGCAAA
    GTGAACTTTGAGAAGAAATCTCAAACACAAATTGCTCAAATCGTTCAAAACGGTTGGGAC
    AAATTGCCAATCTGTATGGCTAAAACTCAATACAGTTTCTCAGATAATCCAAATGCGCTT
    GGAGCACCAGAAAACTTTGAAATTACCATTCGTGAATTGGTACCAAAATTAGGTGCAGGC
    TTCATCGTTGCCTTAACTGGTGATGTTATGACCATGCCAGGTCTTCCAAAACGTCCAGCA
    GCTCTCAACATGGATGTTGAAAGCGATGGAACTGTACTAGGCTTGTTCTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1671

Insert paragraph

This data comes from external databases and cannot be edited.

Insert paragraph

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: spr1109 [new locus tag: SPR_RS05535 ]
  • symbol: Fhs
  • description: Formate--tetrahydrofolate ligase
  • length: 556
  • theoretical pI: 5.09027
  • theoretical MW: 59629.3
  • GRAVY: 0.069964

Insert paragraph

⊟Function[edit | edit source]

  • ⊞reaction:
    EC 6.3.4.3?  ExPASy
    Formate--tetrahydrofolate ligase ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate
  • TIGRFAM:
  • ⊞TheSEED  :
    • Formate--tetrahydrofolate ligase (EC 6.3.4.3)
    Carbohydrates One-carbon Metabolism One-carbon metabolism by tetrahydropterines  Formate--tetrahydrofolate ligase (EC 6.3.4.3)
    and 3 more
    Carbohydrates One-carbon Metabolism Serine-glyoxylate cycle  Formate--tetrahydrofolate ligase (EC 6.3.4.3)
    Cofactors, Vitamins, Prosthetic Groups, Pigments Folate and pterines Folate Biosynthesis  Formate--tetrahydrofolate ligase (EC 6.3.4.3)
    Miscellaneous Miscellaneous - no subcategory EC 6.3.4.- Ligases that form carbon-nitrogen bonds  Formate--tetrahydrofolate ligase (EC 6.3.4.3)
  • ⊞PFAM:
    P-loop_NTPase (CL0023) FTHFS; Formate--tetrahydrofolate ligase (PF01268; HMM-score: 878.4)
    and 2 more
    CbiA; CobQ/CobB/MinD/ParA nucleotide binding domain (PF01656; HMM-score: 18.4)
    no clan defined DUF719; Protein of unknown function (DUF719) (PF05334; HMM-score: 14)

Insert paragraph

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

Insert paragraph

⊟Localization[edit | edit source]

  • ⊞PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • ⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.003959
    • TAT(Tat/SPI): 0.000607
    • LIPO(Sec/SPII): 0.000373
  • predicted transmembrane helices (TMHMM): 0

Insert paragraph

⊟Accession numbers[edit | edit source]

Insert paragraph

⊟Protein sequence[edit | edit source]

  • MKTDIEIAQSIELKPIVDVVEKLGISYDDLELYGKYKAKLSFDKIRAVESNPVGKLILVTAINPTPAGEGKSTLTIGLADALNKIGKKTMIAIREPSLGPVMGIKGGAAGGGYAQVLPMEDINLHFTGDMHAITTANNALSALIDNHLHQGNELGIDQRRILWKRVVDLNDRALRHVTVGLGGPLNGIPREDGFDITVASEIMAILCLATDIEDLKRRLANIVIGYRYDRTPVSVGDLQVEGALALILKDAIKPNLVQTIYGTPAFVHGGPFANIAHGCNSVLATTTALHLADYTVTEAGFGADLGAEKFLDIKTPNLPTSPDAVVIVATLRALKMNGGVAKDALTEENVEAVRAGFANLKRHVENIRKFGIPAVVAINEFVSDTEAEIAVLKELCASIDVPVELASVWADGAEGGVALAETVVKTIAENPANYKRLYDNDLSVQEKIEKIVTEIYRGSKVNFEKKSQTQIAQIVQNGWDKLPICMAKTQYSFSDNPNALGAPENFEITIRELVPKLGAGFIVALTGDVMTMPGLPKRPAALNMDVESDGTVLGLF

Insert paragraph

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

Insert paragraph

⊟Expression & Regulation[edit | edit source]

Insert paragraph

⊟Operon[edit | edit source]

Insert paragraph

⊟Regulation[edit | edit source]

  • ⊞regulators: MtaR* (repression) regulon, PurR (repression) regulon

Insert paragraph

⊟Expression data[edit | edit source]

Insert paragraph

⊞Biological Material[edit | edit source]

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

⊞Other Information[edit | edit source]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

Insert paragraph

⊟Relevant publications[edit | edit source]

Insert paragraph