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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 24-APR-2024

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⊟Summary[edit | edit source]

Contents

  • 1 Summary
  • 2 Genome View
  • 3 Gene
    • 3.1 General
    • 3.2 Accession numbers
    • 3.3 Phenotype
    • 3.4 DNA sequence
  • 4 Protein
    • 4.1 General
    • 4.2 Function
    • 4.3 Structure, modifications & cofactors
    • 4.4 Localization
    • 4.5 Accession numbers
    • 4.6 Protein sequence
    • 4.7 Experimental data
  • 5 Expression & Regulation
    • 5.1 Operon
    • 5.2 Regulation
    • 5.3 Expression data
  • 6 Biological Material
    • 6.1 Mutants
    • 6.2 Expression vector
    • 6.3 lacZ fusion
    • 6.4 GFP fusion
    • 6.5 two-hybrid system
    • 6.6 FLAG-tag construct
    • 6.7 Antibody
  • 7 Other Information
  • 8 Literature
    • 8.1 References
    • 8.2 Relevant publications
  • organism: Streptococcus pneumoniae G54
  • locus tag: SPG_RS04135 [old locus tag: SPG_0819 ]
  • pan locus tag?: PNEUPAN001903000
  • symbol: SPG_RS04135
  • pan gene symbol?: argR2
  • synonym:
  • product: arginine repressor

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPG_RS04135 [old locus tag: SPG_0819 ]
  • symbol: SPG_RS04135
  • product: arginine repressor
  • replicon: chromosome
  • strand: -
  • coordinates: 794221..794691
  • length: 471
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_011072 (794221..794691) NCBI
  • BioCyc: SPG_RS04135 BioCyc
  • MicrobesOnline: see SPG_0819
  • PneumoBrowse for strain D39V: SPV_0786 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    ATGAATAAATCAGAACACCGCCACCAACTTATACGCGCTCTTATCACAAAAAACAAGATT
    CATACACAGGCTGAGTTGCAAGCCCTTCTTGCTAAGAACGACATTCAAGTAACCCAGGCA
    ACCCTCTCACGCGACATCAAAAATATGAACCTATCAAAAGTCCGCGAAGAAGATAGCGCT
    TATTATGTTCTTAACAATGGTTCCATCTCAAAATGGGAAAAACGTCTCGAACTNTACATG
    GAAGACGCCCTTGTCTGGATGCGCCCAGTTCAACACCAAGTCCTACTAAAAACCCTTCCT
    GGACTGGCTCAATCCTTTGGTTCTATCATTGATACTTTGAGCTTCCCTGACGCTATCGCT
    ACCCTTTGTGGTAATGATGTCTGTCTTATCATCTGTGAAGATGCAGATACTGCTCAAAAG
    TGCTTTGAAGAACTGAAAAAATTCGCCCCACCATTTTTCTTTGAAGAATAA
    60
    120
    180
    240
    300
    360
    420
    471

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPG_RS04135 [old locus tag: SPG_0819 ]
  • symbol: SPG_RS04135
  • description: arginine repressor
  • length: 156
  • theoretical pI: 6.10847
  • theoretical MW: 17841.5
  • GRAVY: -0.230769

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Amino acid biosynthesis Glutamate family arginine repressor (TIGR01529; HMM-score: 119.8)
    Signal transduction Regulatory functions DNA interactions arginine repressor (TIGR01529; HMM-score: 119.8)
  • TheSEED: see SPG_0819
  • ⊞PFAM:
    HTH (CL0123) Arg_repressor; Arginine repressor, DNA binding domain (PF01316; HMM-score: 79.5)
    no clan defined Arg_repressor_C; Arginine repressor, C-terminal domain (PF02863; HMM-score: 63.8)
    and 5 more
    SMC_hinge; SMC proteins Flexible Hinge Domain (PF06470; HMM-score: 19.8)
    DUF3135; Protein of unknown function (DUF3135) (PF11333; HMM-score: 14.1)
    NADP_Rossmann (CL0063) PRMT5; PRMT5 arginine-N-methyltransferase (PF05185; HMM-score: 13.7)
    RRM (CL0221) SET_assoc; Histone lysine methyltransferase SET associated (PF11767; HMM-score: 13.1)
    no clan defined DUF3427; Domain of unknown function (DUF3427) (PF11907; HMM-score: 12.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • genes regulated by ArgR2*, TF important in Arginine biosynthesis, Arginine degradation: in TIGR4

⊟Localization[edit | edit source]

  • ⊞PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.67
    • Cytoplasmic Membrane Score: 0.01
    • Cellwall Score: 0.15
    • Extracellular Score: 0.17
    • Internal Helices: 0
  • ⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.015047
    • TAT(Tat/SPI): 0.003485
    • LIPO(Sec/SPII): 0.001898
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_001042996 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MNKSEHRHQLIRALITKNKIHTQAELQALLAKNDIQVTQATLSRDIKNMNLSKVREEDSAYYVLNNGSISKWEKRLELYMEDALVWMRPVQHQVLLKTLPGLAQSFGSIIDTLSFPDAIATLCGNDVCLIICEDADTAQKCFEELKKFAPPFFFEE

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

  • MicrobesOnline: SPG_RS04135 < SPG_RS04140

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V: SPV_0786 PneumoExpress

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Christian Schulz, Philipp Gierok, Lothar Petruschka, Michael Lalk, Ulrike Mäder, Sven Hammerschmidt
Regulation of the arginine deiminase system by ArgR2 interferes with arginine metabolism and fitness of Streptococcus pneumoniae.
mBio: 2014, 5(6);
[PubMed:25538192] [WorldCat.org] [DOI] (I e)

Retrieved from "http://pneumowiki.med.uni-greifswald.de/index.php?title=SPG_RS04135&oldid=71667"
  • This page was last edited on 20 January 2022, at 15:48.
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