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serotype 4
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serotype 19A
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serotype 1
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serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
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R6
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serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
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SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 25-NOV-2024

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae R6
  • locus tag: SPR_RS01115 [old locus tag: spr0210 ]
  • pan locus tag?: PNEUPAN000981000
  • symbol: SPR_RS01115
  • pan gene symbol?: adk
  • synonym:
  • product: adenylate kinase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPR_RS01115 [old locus tag: spr0210 ]
  • symbol: SPR_RS01115
  • product: adenylate kinase
  • replicon: chromosome
  • strand: +
  • coordinates: 207070..207708
  • length: 639
  • essential: yes [1] DEG other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    ATGAATCTTTTGATTATGGGCTTACCTGGTGCAGGTAAGGGAACTCAAGCAGCAAAAATC
    GTAGAACAATTCCATGTTGCACATATCTCAACAGGTGATATGTTCCGCGCTGCAATGGCA
    AATCAAACTGAAATGGGTGTTCTTGCTAAGTCATATATTGACAAGGGTGAATTGGTTCCT
    GACGAAGTTACAAATGGAATCGTAAAAGAACGCCTTTCACAAGATGATATTAAAGAAACA
    GGATTCTTATTGGATGGTTACCCACGTACAATTGAACAAGCTCATGCCTTGGACAAAACA
    TTGGCTGAACTTGGCATTGAACTAGAAGGTATTATCAATATTGAAGTGAACCCTGACAGC
    CTCTTGGAACGTTTGAGTGGCCGTATCATCCACCGCGTAACTGGAGAAACTTTCCACAAG
    GTCTTTAACCCACCAGTTGACTATAAAGAAGAAGATTACTACCAACGTGAAGATGATAAG
    CCTGAGACAGTAAAACGTCGTTTGGATGTTAATATTGCTCAAGGAGAACCAATCATTGCT
    CACTACCGTGCCAAAGGTTTGGTTCATGACATCGAAGGTAATCAAGATATCAATGATGTC
    TTCTCAGATATTGAAAAAGTATTGACAAATTTGAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    639

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPR_RS01115 [old locus tag: spr0210 ]
  • symbol: SPR_RS01115
  • description: adenylate kinase
  • length: 212
  • theoretical pI: 4.72498
  • theoretical MW: 23720.7
  • GRAVY: -0.387736

⊟Function[edit | edit source]

  • ⊞reaction:
    EC 2.7.4.3?  ExPASy
    Adenylate kinase ATP + AMP = 2 ADP
  • ⊞TIGRFAM:
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Nucleotide and nucleoside interconversions adenylate kinase (TIGR01351; EC 2.7.4.-; HMM-score: 241.4)
    and 7 more
    UMP-CMP kinase family (TIGR01359; EC 2.7.4.-; HMM-score: 131.6)
    adenylate kinase (TIGR01360; EC 2.7.4.3; HMM-score: 117.4)
    putative cytidylate kinase (TIGR02173; EC 2.7.4.14; HMM-score: 25.5)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking signal recognition particle-docking protein FtsY (TIGR00064; HMM-score: 17)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Nucleotide and nucleoside interconversions cytidylate kinase (TIGR00017; EC 2.7.4.14; HMM-score: 15.7)
    carbohydrate kinase, thermoresistant glucokinase family (TIGR01313; EC 2.7.1.-; HMM-score: 14.8)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking signal recognition particle protein (TIGR00959; HMM-score: 12)
  • TheSEED: see spr0210
  • ⊞PFAM:
    P-loop_NTPase (CL0023) ADK; Adenylate kinase (PF00406; HMM-score: 187.2)
    and 7 more
    AAA_17; AAA domain (PF13207; HMM-score: 91.5)
    AAA_18; AAA domain (PF13238; HMM-score: 24.3)
    AAA_33; AAA domain (PF13671; HMM-score: 21.7)
    SRP54; SRP54-type protein, GTPase domain (PF00448; HMM-score: 18.6)
    no clan defined ADK_lid; Adenylate kinase, active site lid (PF05191; HMM-score: 13.8)
    P-loop_NTPase (CL0023) Cytidylate_kin; Cytidylate kinase (PF02224; HMM-score: 13.3)
    Thymidylate_kin; Thymidylate kinase (PF02223; HMM-score: 13.1)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • ⊞PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • ⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.034194
    • TAT(Tat/SPI): 0.002651
    • LIPO(Sec/SPII): 0.002835
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MNLLIMGLPGAGKGTQAAKIVEQFHVAHISTGDMFRAAMANQTEMGVLAKSYIDKGELVPDEVTNGIVKERLSQDDIKETGFLLDGYPRTIEQAHALDKTLAELGIELEGIINIEVNPDSLLERLSGRIIHRVTGETFHKVFNPPVDYKEEDYYQREDDKPETVKRRLDVNIAQGEPIIAHYRAKGLVHDIEGNQDINDVFSDIEKVLTNLK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ Jane A Thanassi, Sandra L Hartman-Neumann, Thomas J Dougherty, Brian A Dougherty, Michael J Pucci
    Identification of 113 conserved essential genes using a high-throughput gene disruption system in Streptococcus pneumoniae.
    Nucleic Acids Res: 2002, 30(14);3152-62
    [PubMed:12136097] [WorldCat.org] [DOI] (I p)

⊟Relevant publications[edit | edit source]

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