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serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 30-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae R6
  • locus tag: spr0402 [new locus tag: SPR_RS02060 ]
  • pan locus tag?: PNEUPAN001292000
  • symbol: ilvN
  • pan gene symbol?: ilvH
  • synonym:
  • product: Acetolactate synthase small subunit

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: spr0402 [new locus tag: SPR_RS02060 ]
  • symbol: ilvN
  • product: Acetolactate synthase small subunit
  • replicon: chromosome
  • strand: +
  • coordinates: 399026..399526
  • length: 501
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    ATGAGATGTTGGGGGTGCAGTTCCATGCGTAGAATGTTAACAGCAAAACTACAAAATCGT
    TCAGGAGTCCTCAATCGCTTTACAGGTGTCCTATCTCGTCGTCAGGTTAATATTGAAAGC
    ATCTCTGTTGGAGCAACAGAAGATCCGAATGTATCGCGTATCACTATTATTATTGATGTT
    GCTTCTCATGATGAAGTGGAGCAAATCATCAAACAGCTCAATCGTCAGATTGATGTGATT
    CGCATTCGAGATATTACAGACAAGCCTCATTTGGAGCGCGAGGTGATTTTGGTTAAGATG
    TCAGCGCCAGCTGAGAAGAGAGCTGAGATTTTAGCGATTATTCAACCTTTCCGTGCAACA
    GTGGTAGACGTAGCGCCAAGCTCGATTACCATTCAGATGACGGGAAATGCAGAAAAGAGC
    GAAGCCCTATTGCGAGTCATTCGCCCATACGGTATTCGCAATATTGCTCGAACGGGTGCA
    ACTGGATTTACCCGCGATTAA
    60
    120
    180
    240
    300
    360
    420
    480
    501

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: spr0402 [new locus tag: SPR_RS02060 ]
  • symbol: IlvN
  • description: Acetolactate synthase small subunit
  • length: 166
  • theoretical pI: 10.7591
  • theoretical MW: 18605.5
  • GRAVY: -0.13253

⊟Function[edit | edit source]

  • ⊞reaction:
    EC 2.2.1.6?  ExPASy
    Acetolactate synthase 2 pyruvate = 2-acetolactate + CO2
  • ⊞TIGRFAM:
    Metabolism Amino acid biosynthesis Pyruvate family acetolactate synthase, small subunit (TIGR00119; EC 2.2.1.6; HMM-score: 177.2)
    and 6 more
    Metabolism Amino acid biosynthesis Aspartate family aspartate kinase, monofunctional class (TIGR00656; EC 2.7.2.4; HMM-score: 24.6)
    Metabolism Amino acid biosynthesis Serine family phosphoglycerate dehydrogenase (TIGR01327; EC 1.1.1.95; HMM-score: 20.8)
    Cellular processes Cellular processes Adaptations to atypical conditions RelA/SpoT family protein (TIGR00691; HMM-score: 17)
    Metabolism Energy metabolism Amino acids and amines tryptophan 5-monooxygenase (TIGR01270; EC 1.14.16.4; HMM-score: 15.7)
    Hypothetical proteins Conserved TIGR02147 family protein (TIGR02147; HMM-score: 13.5)
    Metabolism Amino acid biosynthesis Aspartate family aspartate kinase (TIGR00657; EC 2.7.2.4; HMM-score: 13.1)
  • ⊞TheSEED  :
    • Acetolactate synthase small subunit (EC 2.2.1.6)
    Amino Acids and Derivatives Branched-chain amino acids Branched-Chain Amino Acid Biosynthesis  Acetolactate synthase small subunit (EC 2.2.1.6)
    and 1 more
    Carbohydrates Fermentation Acetoin, butanediol metabolism  Acetolactate synthase small subunit (EC 2.2.1.6)
  • ⊞PFAM:
    ACT (CL0070) ALS_ss_C; Small subunit of acetolactate synthase (PF10369; HMM-score: 89.5)
    and 5 more
    ACT; ACT domain (PF01842; HMM-score: 52.7)
    ACT_5; ACT domain (PF13710; HMM-score: 49.8)
    ACT_4; ACT domain (PF13291; HMM-score: 35.4)
    ACT_6; ACT domain (PF13740; HMM-score: 18.6)
    no clan defined DUF5301; Domain of unknown function (DUF5300) (PF17225; HMM-score: 16.1)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • ⊞PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 1.78
    • Cytoplasmic Membrane Score: 8.16
    • Cellwall Score: 0.06
    • Extracellular Score: 0.01
    • Internal Helices: 0
  • ⊞DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.6109
    • Cytoplasmic Membrane Score: 0.2183
    • Cell wall & surface Score: 0.0004
    • Extracellular Score: 0.1704
  • ⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.009127
    • TAT(Tat/SPI): 0.003898
    • LIPO(Sec/SPII): 0.003003
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MRCWGCSSMRRMLTAKLQNRSGVLNRFTGVLSRRQVNIESISVGATEDPNVSRITIIIDVASHDEVEQIIKQLNRQIDVIRIRDITDKPHLEREVILVKMSAPAEKRAEILAIIQPFRATVVDVAPSSITIQMTGNAEKSEALLRVIRPYGIRNIARTGATGFTRD

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • ⊞regulator: CodY (repression) regulon

⊟Expression data[edit | edit source]

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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