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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 05-OCT-2017

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae MDRSPN001
  • locus tag: MDRSPN_00388 [new locus tag: MDRSPN_RS02090 ]
  • pan locus tag?: PNEUPAN001280000
  • symbol: MDRSPN_00388
  • pan gene symbol?: gutB
  • synonym:
  • product: dehydrogenase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: MDRSPN_00388 [new locus tag: MDRSPN_RS02090 ]
  • symbol: MDRSPN_00388
  • product: dehydrogenase
  • replicon: chromosome
  • strand: -
  • coordinates: 384390..385433
  • length: 1044
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: AP018391 (384390..385433) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    ATGGCTACAATGAAGGCAGCTCGCTGGCATGCAGCGAAAGATGTTCGTATTCAAGAAATA
    GAAGTTCCTGAAGTACTTCCGCACCAAGTAAAAGTTGCAGTTAAGTTCACAGGAATTTGT
    GGTACTGACCTCCATGAATTTTTAGATGGACCTATCTTTATCCCAACAGATGAGCACGTC
    TATTCTGGTCAAAAAGCACCGGTAACACTGGGACATGAATTTTCTGGTGAAATCATAGAA
    GTCGGAAGCGATGTTACCCGTGTTAAAGTTGGTGATCGTGTTGCTGTGGAACCAATTCTA
    GCTAAAAATAACTTAGTTGGTGATTATAATTTGGATCCAAACCTTAATTTTGTCGGTTTG
    GCTGCAGACGGTGGATTTGCCAAATATTGTGTTTTAGACGGTGACTTAGTACATGTCATT
    CCAGATAGTTTGAGCTATGAGCAAGCTGCTCTTACTGAACCCGCTGCTGTTGCAGTCTAT
    GCTGTTCGTCAATCTTCTTTGAAGGCTGGCGATACAGCTGTTGTCTTTGGTTTAGGCCCG
    ATTGGTCTATTAATTGTAGAAGCTCTTCGTGCAGCTGGTGCTTCTAAGATTTATGCTGTT
    GAACTATCACCTGAACGTCAAGCAAAAGCTGAAGAGTTAGGAGCTATCGTTGTCCGTCCG
    GAAGAAGGTGAAACAGCTGTTGAAGCTATTCATCGTTTAACAAACGGTGGTGTAGATGTT
    TCTTATGAAGTAACGGGTGTGCCAGTAGTTTTAGGACAAGCCTTAGCTGCCGTACATAAA
    GCAGGTGAGTGCATGGTGGTCTCTATCTGGGAACGAGAAGCAAATATTAATCCGAATGAA
    TTTGCAATCCAAGAAAAGACACTAAAAGGAATCATTGCTTATCGTCATATCTTCCCTAAA
    GTATTAGAATTGATGGAACAAGGCTACTTCTCTGCTGAAAAATTAGTTACTAAGAAAATT
    AAATTGGAAAATATCGTCGAAGAAGACTTTATCGAATTAACTCAAGATAAGTCACAAATT
    AAAATTTTGGTAGAACCAGAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1044

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: MDRSPN_00388 [new locus tag: MDRSPN_RS02090 ]
  • symbol: MDRSPN_00388
  • description: dehydrogenase
  • length: 347
  • theoretical pI: 4.65352
  • theoretical MW: 37596.9
  • GRAVY: 0.100576

⊟Function[edit | edit source]

  • ⊞TIGRFAM:
    Metabolism Energy metabolism Amino acids and amines L-threonine 3-dehydrogenase (TIGR00692; EC 1.1.1.103; HMM-score: 162.9)
    and 14 more
    Unknown function Enzymes of unknown specificity NDMA-dependent alcohol dehydrogenase, Rxyl_3153 family (TIGR03989; EC 1.1.99.36; HMM-score: 117.3)
    Cellular processes Cellular processes Detoxification S-(hydroxymethyl)mycothiol dehydrogenase (TIGR03451; EC 1.1.1.306; HMM-score: 97.1)
    Cellular processes Cellular processes Detoxification S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase (TIGR02818; EC 1.1.1.1,1.1.1.284; HMM-score: 95.7)
    Metabolism Energy metabolism Fermentation S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase (TIGR02818; EC 1.1.1.1,1.1.1.284; HMM-score: 95.7)
    putative phosphonate catabolism associated alcohol dehydrogenase (TIGR03366; HMM-score: 79.3)
    Unknown function Enzymes of unknown specificity putative NAD(P)H quinone oxidoreductase, PIG3 family (TIGR02824; HMM-score: 66.4)
    crotonyl-CoA carboxylase/reductase (TIGR01751; EC 1.3.1.85; HMM-score: 64.5)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Chlorophyll and bacteriochlorphyll chlorophyll synthesis pathway protein BchC (TIGR01202; HMM-score: 64.3)
    Metabolism Energy metabolism Fermentation zinc-binding alcohol dehydrogenase family protein (TIGR02822; EC 1.-.-.-; HMM-score: 56.5)
    6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase (TIGR03201; EC 1.1.1.-; HMM-score: 51.5)
    Metabolism Central intermediary metabolism One-carbon metabolism formaldehyde dehydrogenase, glutathione-independent (TIGR02819; EC 1.2.1.46; HMM-score: 44)
    Unknown function Enzymes of unknown specificity putative quinone oxidoreductase, YhdH/YhfP family (TIGR02823; HMM-score: 25.6)
    Metabolism Energy metabolism Fermentation zinc-binding alcohol dehydrogenase family protein (TIGR02817; HMM-score: 24.2)
    Unknown function Enzymes of unknown specificity putative dehydratase, YjhG/YagF family (TIGR03432; HMM-score: 11.8)
  • TheSEED:
  • ⊞PFAM:
    GroES (CL0296) ADH_N; Alcohol dehydrogenase GroES-like domain (PF08240; HMM-score: 83.6)
    NADP_Rossmann (CL0063) ADH_zinc_N; Zinc-binding dehydrogenase (PF00107; HMM-score: 82.7)
    and 3 more
    Glu_dehyd_C; Glucose dehydrogenase C-terminus (PF16912; HMM-score: 43.2)
    TrkA_N; TrkA-N domain (PF02254; HMM-score: 16.4)
    2-Hacid_dh_C; D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain (PF02826; HMM-score: 14.4)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • ⊞PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • ⊞DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9717
    • Cytoplasmic Membrane Score: 0.0109
    • Cell wall & surface Score: 0.0002
    • Extracellular Score: 0.0172
  • ⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.005071
    • TAT(Tat/SPI): 0.000268
    • LIPO(Sec/SPII): 0.000574
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: BBA58594 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MATMKAARWHAAKDVRIQEIEVPEVLPHQVKVAVKFTGICGTDLHEFLDGPIFIPTDEHVYSGQKAPVTLGHEFSGEIIEVGSDVTRVKVGDRVAVEPILAKNNLVGDYNLDPNLNFVGLAADGGFAKYCVLDGDLVHVIPDSLSYEQAALTEPAAVAVYAVRQSSLKAGDTAVVFGLGPIGLLIVEALRAAGASKIYAVELSPERQAKAEELGAIVVRPEEGETAVEAIHRLTNGGVDVSYEVTGVPVVLGQALAAVHKAGECMVVSIWEREANINPNEFAIQEKTLKGIIAYRHIFPKVLELMEQGYFSAEKLVTKKIKLENIVEEDFIELTQDKSQIKILVEPE

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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