⊟Summary[edit | edit source]

PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 03-AUG-2015

⊟Summary

• organism: Streptococcus pneumoniae ST556
locus tag: MYY_0973 [new locus tag: MYY_RS04970 ]
pan locus tag^?: PNEUPAN002553000
symbol: MYY_0973
pan gene symbol^?: licC
• synonym:
• product: CTP:phosphocholine cytidylyltransferase

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: MYY_0973 [new locus tag: MYY_RS04970 ]
• symbol: MYY_0973
• product: CTP:phosphocholine cytidylyltransferase
• replicon: chromosome
• strand: +
• coordinates: 945782..946471
• length: 690
• essential: unknown other strains

⊟Accession numbers

• Location: CP003357 (945782..946471) NCBI
• BioCyc: see MYY_RS04970
• MicrobesOnline:
• PneumoBrowse for strain D39V: SPV_1123 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  
  GTGAAAGCCATTATCTTAGCAGCGGGATTGGGAACTCGCTTGCGTCCTATGACTGAAAAT
  ACCCCTAAAGCCTTGGTTCAGGTTAATCAAAAACCTTTGATTGAATACCAAATTGAGTTT
  CTCAAAGAAAAAGGAATCAATGACATCATCATCATCGTTGGTTATCTTAAAGAACAATTC
  GATTATTTAAAAGAAAAATACGGTGTTCGCCTCGTTTTCAATGATAAATACGCTGACTAC
  AATAACTTTTACTCTCTCTATCTTGTAAAAGAAGAATTGGCCAACAGCTATGTTATTGAT
  GCTGACAATTATCTCTTTAAAAATATGTTCCGCAATGATTTGACACGTTCGACTTATTTT
  AGTGTTTATCGTGAAGATTGTACCAACGAATGGTTCTTGGTCTATGGAGATGACTACAAG
  GTTCAAGACATTATTGTTGATAGCAAGGCAGGTCGCATCCTTAGTGGTGTATCCTTCTGG
  GATGCTCCAACTGCAGAAAAGATTGTCAGCTTTATCGACAAGGCTTATGCAAGTGGTGAA
  TTTGTTGATCTCTATTGGGACAATATGGTTAAGGATAATATCAAAGAGCTAGATGTCTAT
  GTTGAAGAATTAGAAGGCAATAGCATTTATGAGATCGATAGTGTCCAAGACTATCGTAAA
  TTAGAAGAAATTCTTAAAAACGAAAATTAA
  60
  120
  180
  240
  300
  360
  420
  480
  540
  600
  660
  690
  

⊟Protein

⊟General

• locus tag: MYY_0973 [new locus tag: MYY_RS04970 ]
• symbol: MYY_0973
• description: CTP:phosphocholine cytidylyltransferase
• length: 229
• theoretical pI: 4.32935
• theoretical MW: 26875.3
• GRAVY: -0.328384

⊟Function

• ⊞⊞TIGRFAM:
  UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase (TIGR03992; EC 2.3.1.157,2.7.7.23; HMM-score: 75.7)
  glucose-1-phosphate thymidylyltransferase (TIGR01208; EC 2.7.7.24; HMM-score: 61.9)
  and 13 more
  Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides UTP--glucose-1-phosphate uridylyltransferase (TIGR01099; EC 2.7.7.9; HMM-score: 50)
  Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides glucose-1-phosphate cytidylyltransferase (TIGR02623; EC 2.7.7.33; HMM-score: 38.7)
  Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides glucose-1-phosphate thymidylyltransferase (TIGR01207; EC 2.7.7.24; HMM-score: 37.2)
  Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase (TIGR01173; EC 2.3.1.157,2.7.7.23; HMM-score: 34.7)
  Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase (TIGR01173; EC 2.3.1.157,2.7.7.23; HMM-score: 34.7)
  Metabolism Central intermediary metabolism Amino sugars UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase (TIGR01173; EC 2.3.1.157,2.7.7.23; HMM-score: 34.7)
  molybdenum cofactor cytidylyltransferase (TIGR03310; EC 2.7.7.76; HMM-score: 29.5)
  Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (TIGR00453; EC 2.7.7.60; HMM-score: 28.7)
  Signal transduction Regulatory functions Protein interactions regulatory protein GalF (TIGR01105; HMM-score: 25.8)
  Hypothetical proteins Conserved TIGR00454 family protein (TIGR00454; HMM-score: 25.3)
  Metabolism Energy metabolism Biosynthesis and degradation of polysaccharides glucose-1-phosphate adenylyltransferase (TIGR02091; EC 2.7.7.27; HMM-score: 21.7)
  Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Molybdopterin molybdenum cofactor guanylyltransferase (TIGR02665; EC 2.7.7.77; HMM-score: 16.9)
  methylmalonyl-CoA mutase C-terminal domain (TIGR00640; HMM-score: 12.1)
• TheSEED  :
  • Choline-phosphate cytidylyltransferase (EC 2.7.7.15)
  Cell Wall and Capsule Capsular and extracellular polysacchrides Phosphorylcholine incorporation in LPS  Cholinephosphate cytidylyltransferase (EC 2.7.7.15)
• ⊞⊞PFAM:
  GT-A (CL0110) NTP_transferase; Nucleotidyl transferase (PF00483; HMM-score: 48)
  NTP_transf_3; MobA-like NTP transferase domain (PF12804; HMM-score: 47.1)
  and 2 more
  IspD; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (PF01128; HMM-score: 25)
  DUF6564; Domain of unknown function (DUF6564) (PF20202; HMM-score: 20.2)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• ⊞⊞PSORTb: Cytoplasmic
  • Cytoplasmic Score: 7.5
  • Cytoplasmic Membrane Score: 1.15
  • Cellwall Score: 0.62
  • Extracellular Score: 0.73
  • Internal Helices: 0
• ⊞⊞SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.024463
  • TAT(Tat/SPI): 0.000365
  • LIPO(Sec/SPII): 0.005147
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: AFC94634 NCBI
• UniProt:

⊟Protein sequence

• MKAIILAAGLGTRLRPMTENTPKALVQVNQKPLIEYQIEFLKEKGINDIIIIVGYLKEQFDYLKEKYGVRLVFNDKYADYNNFYSLYLVKEELANSYVIDADNYLFKNMFRNDLTRSTYFSVYREDCTNEWFLVYGDDYKVQDIIVDSKAGRILSGVSFWDAPTAEKIVSFIDKAYASGEFVDLYWDNMVKDNIKELDVYVEELEGNSIYEIDSVQDYRKLEEILKNEN

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator:

⊟Expression data

• PneumoExpress for strain D39V: SPV_1123 PneumoExpress

⊞Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊞Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications

C O Rock, R J Heath, H W Park, S Jackowski
The licC gene of Streptococcus pneumoniae encodes a CTP:phosphocholine cytidylyltransferase.
J Bacteriol: 2001, 183(16);4927-31
[PubMed:11466299] [WorldCat.org] [DOI] (P p)