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From PneumoWiki
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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 17-JAN-2018

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae AP200
  • locus tag: SPAP_2091 [new locus tag: SPAP_RS10360 ]
  • pan locus tag?: PNEUPAN003799000
  • symbol: SPAP_2091
  • pan gene symbol?: MATE
  • synonym:
  • product: Na+-driven multidrug efflux pump

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPAP_2091 [new locus tag: SPAP_RS10360 ]
  • symbol: SPAP_2091
  • product: Na+-driven multidrug efflux pump
  • replicon: chromosome
  • strand: -
  • coordinates: 1942511..1943791
  • length: 1281
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    TTGTTTAAGAAAAATAAAGACATTCTTAATATTGCATTGCCAGCTATGGGTGAAAACTTT
    TTGCAGATGCTAATGGGAATGGTGGACAGTTATTTGGTTGCTCATTTAGGATTGATAGCT
    ATTTCAGGGGTTTCAGTAGCTGGTAATATTATCACCATTTATCAGGCGATTTTCATCGCT
    CTGGGAGCTGCTATTTCCAGTGTTATTTCAAAAAGCATAGGGCAGAAAGACCAGTCGAAG
    TTGGCCTATCATGTGACTGAGGCGTTGAAGATTACCTTACTATTAAGTTTCCTTTTAGGA
    TTTTTGTCCATCTTCGCTGGGAAAGAGATGATAGGACTTTTGGGGACGGAGAGGGATGTA
    GCTGAGAGTGGTGGACTGTATCTATCTCTGGTAGGCGGATCGATTGTTCTCTTAGGTTTA
    ATGACTAGTCTAGGAGCCTTGATTCGTGCAACGCATAATCCACGTCTGCCTCTCTATGTT
    AGTTTTTTATCCAATGCCTTGAATATTCTTTTTTCAAGTCTAGCTATTTTTGTTCTGGAT
    ATGGGGATAGCTGGTGTTGCTTGGGGGACAATTGTGTCTCGTTTGGTTGGTCTTGTGATT
    TTGTGGTCACAATTAAAACTGCCTTATGGGAAGCCAACTTTTGGTTTAGATAAGGAACTG
    TTGACCTTGGCTTTACCAGCAGCTGGAGAGCGACTTATGATGAGGGCTGGAGATGTAGTG
    ATCATTGCCTTGGTCGTTTCTTTTGGGACGGAGGCAGTTGCTGGGAATGCAATCGGAGAA
    GTCTTGACCCAGTTTAACTATATGCCTGCCTTTGGCGTCGCTACGGCAACGGTCATGCTG
    TTGGCCCGAGCAGTTGGAGAGGATGATTGGAAAAGAGTTGCTAGTTTGAGTAAACAAACC
    TTTTGGCTTTCTCTGTTCCTCATGTTGCCCCTGTCCTTTAGTATATATGTCTTGGGTGTA
    CCATTAACTCATCTCTATACGACTGATTCTCTAGCGGTGGAGGCTAGTGTTCTAGTGACA
    CTGTTTTCACTACTTGGGACCCCTATGACGACAGGAACAGTCATCTATACGGCAGTCTGG
    CAGGGATTAGGAAATGCACGCCTCCCTTTTTATGCGACAAGTATAGGCATGTGGTGTATC
    CGCATTGGGACAGGATATCTGATGGGGATTGTGCTTGGTTGGGGCTTGCCTGGTATTTGG
    GCAGGGTCTCTCTTGGATAATGGTTTTCGCTGGTTATTTCTACGCTATCGTTACCAGCGC
    TATATGAACTTGAAAGGATAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1281

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPAP_2091 [new locus tag: SPAP_RS10360 ]
  • symbol: SPAP_2091
  • description: Na+-driven multidrug efflux pump
  • length: 426
  • theoretical pI: 9.56577
  • theoretical MW: 45928.3
  • GRAVY: 0.77277

⊟Function[edit | edit source]

  • ⊞⊞TIGRFAM:
    Metabolism Transport and binding proteins Other MATE efflux family protein (TIGR00797; HMM-score: 200.9)
    and 1 more
    Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan murein biosynthesis integral membrane protein MurJ (TIGR01695; HMM-score: 51.3)
  • TheSEED  :
    • Multi antimicrobial extrusion (MATE) family transporter
  • ⊞⊞PFAM:
    MviN_MATE (CL0222) MatE; MatE (PF01554; HMM-score: 156.6)
    and 2 more
    MurJ; Lipid II flippase MurJ (PF03023; HMM-score: 54.7)
    Polysacc_synt_C; Polysaccharide biosynthesis C-terminal domain (PF14667; HMM-score: 28)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • ⊞⊞PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 11
  • ⊞⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.017493
    • TAT(Tat/SPI): 0.000198
    • LIPO(Sec/SPII): 0.002561
  • predicted transmembrane helices (TMHMM): 11

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: ADM85640 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MFKKNKDILNIALPAMGENFLQMLMGMVDSYLVAHLGLIAISGVSVAGNIITIYQAIFIALGAAISSVISKSIGQKDQSKLAYHVTEALKITLLLSFLLGFLSIFAGKEMIGLLGTERDVAESGGLYLSLVGGSIVLLGLMTSLGALIRATHNPRLPLYVSFLSNALNILFSSLAIFVLDMGIAGVAWGTIVSRLVGLVILWSQLKLPYGKPTFGLDKELLTLALPAAGERLMMRAGDVVIIALVVSFGTEAVAGNAIGEVLTQFNYMPAFGVATATVMLLARAVGEDDWKRVASLSKQTFWLSLFLMLPLSFSIYVLGVPLTHLYTTDSLAVEASVLVTLFSLLGTPMTTGTVIYTAVWQGLGNARLPFYATSIGMWCIRIGTGYLMGIVLGWGLPGIWAGSLLDNGFRWLFLRYRYQRYMNLKG

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Retrieved from "http://pneumowiki.med.uni-greifswald.de/index.php?title=SPAP_2091&oldid=44283"
Insert paragraph

NCBI: 17-JAN-2018

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae AP200
  • locus tag: SPAP_2091 [new locus tag: SPAP_RS10360 ]
  • pan locus tag?: PNEUPAN003799000
  • symbol: SPAP_2091
  • pan gene symbol?: MATE
  • synonym:
  • product: Na+-driven multidrug efflux pump

Insert paragraph

⊟Genome View[edit | edit source]

Insert paragraph

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPAP_2091 [new locus tag: SPAP_RS10360 ]
  • symbol: SPAP_2091
  • product: Na+-driven multidrug efflux pump
  • replicon: chromosome
  • strand: -
  • coordinates: 1942511..1943791
  • length: 1281
  • essential: unknown

Insert paragraph

⊟Accession numbers[edit | edit source]

Insert paragraph

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    TTGTTTAAGAAAAATAAAGACATTCTTAATATTGCATTGCCAGCTATGGGTGAAAACTTT
    TTGCAGATGCTAATGGGAATGGTGGACAGTTATTTGGTTGCTCATTTAGGATTGATAGCT
    ATTTCAGGGGTTTCAGTAGCTGGTAATATTATCACCATTTATCAGGCGATTTTCATCGCT
    CTGGGAGCTGCTATTTCCAGTGTTATTTCAAAAAGCATAGGGCAGAAAGACCAGTCGAAG
    TTGGCCTATCATGTGACTGAGGCGTTGAAGATTACCTTACTATTAAGTTTCCTTTTAGGA
    TTTTTGTCCATCTTCGCTGGGAAAGAGATGATAGGACTTTTGGGGACGGAGAGGGATGTA
    GCTGAGAGTGGTGGACTGTATCTATCTCTGGTAGGCGGATCGATTGTTCTCTTAGGTTTA
    ATGACTAGTCTAGGAGCCTTGATTCGTGCAACGCATAATCCACGTCTGCCTCTCTATGTT
    AGTTTTTTATCCAATGCCTTGAATATTCTTTTTTCAAGTCTAGCTATTTTTGTTCTGGAT
    ATGGGGATAGCTGGTGTTGCTTGGGGGACAATTGTGTCTCGTTTGGTTGGTCTTGTGATT
    TTGTGGTCACAATTAAAACTGCCTTATGGGAAGCCAACTTTTGGTTTAGATAAGGAACTG
    TTGACCTTGGCTTTACCAGCAGCTGGAGAGCGACTTATGATGAGGGCTGGAGATGTAGTG
    ATCATTGCCTTGGTCGTTTCTTTTGGGACGGAGGCAGTTGCTGGGAATGCAATCGGAGAA
    GTCTTGACCCAGTTTAACTATATGCCTGCCTTTGGCGTCGCTACGGCAACGGTCATGCTG
    TTGGCCCGAGCAGTTGGAGAGGATGATTGGAAAAGAGTTGCTAGTTTGAGTAAACAAACC
    TTTTGGCTTTCTCTGTTCCTCATGTTGCCCCTGTCCTTTAGTATATATGTCTTGGGTGTA
    CCATTAACTCATCTCTATACGACTGATTCTCTAGCGGTGGAGGCTAGTGTTCTAGTGACA
    CTGTTTTCACTACTTGGGACCCCTATGACGACAGGAACAGTCATCTATACGGCAGTCTGG
    CAGGGATTAGGAAATGCACGCCTCCCTTTTTATGCGACAAGTATAGGCATGTGGTGTATC
    CGCATTGGGACAGGATATCTGATGGGGATTGTGCTTGGTTGGGGCTTGCCTGGTATTTGG
    GCAGGGTCTCTCTTGGATAATGGTTTTCGCTGGTTATTTCTACGCTATCGTTACCAGCGC
    TATATGAACTTGAAAGGATAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1281

Insert paragraph

This data comes from external databases and cannot be edited.

Insert paragraph

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPAP_2091 [new locus tag: SPAP_RS10360 ]
  • symbol: SPAP_2091
  • description: Na+-driven multidrug efflux pump
  • length: 426
  • theoretical pI: 9.56577
  • theoretical MW: 45928.3
  • GRAVY: 0.77277

Insert paragraph

⊟Function[edit | edit source]

  • ⊞TIGRFAM:
    Metabolism Transport and binding proteins Other MATE efflux family protein (TIGR00797; HMM-score: 200.9)
    and 1 more
    Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan murein biosynthesis integral membrane protein MurJ (TIGR01695; HMM-score: 51.3)
  • TheSEED  :
    • Multi antimicrobial extrusion (MATE) family transporter
  • ⊞PFAM:
    MviN_MATE (CL0222) MatE; MatE (PF01554; HMM-score: 156.6)
    and 2 more
    MurJ; Lipid II flippase MurJ (PF03023; HMM-score: 54.7)
    Polysacc_synt_C; Polysaccharide biosynthesis C-terminal domain (PF14667; HMM-score: 28)

Insert paragraph

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

Insert paragraph

⊟Localization[edit | edit source]

  • ⊞PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 11
  • ⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.017493
    • TAT(Tat/SPI): 0.000198
    • LIPO(Sec/SPII): 0.002561
  • predicted transmembrane helices (TMHMM): 11

Insert paragraph

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: ADM85640 NCBI
  • UniProt:

Insert paragraph

⊟Protein sequence[edit | edit source]

  • MFKKNKDILNIALPAMGENFLQMLMGMVDSYLVAHLGLIAISGVSVAGNIITIYQAIFIALGAAISSVISKSIGQKDQSKLAYHVTEALKITLLLSFLLGFLSIFAGKEMIGLLGTERDVAESGGLYLSLVGGSIVLLGLMTSLGALIRATHNPRLPLYVSFLSNALNILFSSLAIFVLDMGIAGVAWGTIVSRLVGLVILWSQLKLPYGKPTFGLDKELLTLALPAAGERLMMRAGDVVIIALVVSFGTEAVAGNAIGEVLTQFNYMPAFGVATATVMLLARAVGEDDWKRVASLSKQTFWLSLFLMLPLSFSIYVLGVPLTHLYTTDSLAVEASVLVTLFSLLGTPMTTGTVIYTAVWQGLGNARLPFYATSIGMWCIRIGTGYLMGIVLGWGLPGIWAGSLLDNGFRWLFLRYRYQRYMNLKG

Insert paragraph

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

Insert paragraph

⊟Expression & Regulation[edit | edit source]

Insert paragraph

⊟Operon[edit | edit source]

Insert paragraph

⊟Regulation[edit | edit source]

  • regulator:

Insert paragraph

⊟Expression data[edit | edit source]

Insert paragraph

⊞Biological Material[edit | edit source]

Insert paragraph

Insert paragraph

Insert paragraph

Insert paragraph

Insert paragraph

Insert paragraph

Insert paragraph

⊞Other Information[edit | edit source]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

Insert paragraph

⊟Relevant publications[edit | edit source]

Insert paragraph