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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 30-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae R6
  • locus tag: spr0372 [new locus tag: SPR_RS01905 ]
  • pan locus tag?: PNEUPAN001255000
  • symbol: serS
  • pan gene symbol?: serS
  • synonym:
  • product: Seryl-tRNA synthetase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: spr0372 [new locus tag: SPR_RS01905 ]
  • symbol: serS
  • product: Seryl-tRNA synthetase
  • replicon: chromosome
  • strand: -
  • coordinates: 372211..373548
  • length: 1338
  • essential: yes [1] DEG other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    ATGGAACCGTGGCCCTGCCACTCCAACGTTTTGTCAGGGTGCTTTTTTCATAAAGGAGTT
    CTTATGTTAGATATCAAACGTATTCGTACAGATTTTGAAGCTGTCGCAGAAAAATTAGCT
    ACACGTGGTGTAGATGCTGCTGTCTTGAATGAAATGAAAGAAATCGATGCTAAACGTCGT
    AACATCTTGGTCAAGGTTGAAACTCTCAAAGCAGAACGTAACACAGTTTCTGCTGAGATT
    GCCCAAGCTAAGCGCAACAAGGAAAATACAGATGACAAGATTGCTGCCATGCAAAATCTA
    TCTGCTGAGGTTAAAGCCTTGGATGCTGAATTGGCAGAAATCGATGCTAAATTGACAGAA
    TTTACAACGACTCTTCCAAATATCCCAGCTGACAGCGTTCCTGTTGGGGCTGACGAAGAC
    GACAATGTGGAAGTTCGCCGTTGGGGTACTCCACGCGAGTTTGACTTCGAACCTAAAGCT
    CACTGGGATCTCGGTGAAGACCTTGGTATCCTTGACTGGGAACGCGGTGGTAAGGTAACA
    GGCGCTCGCTTCCTCTTCTATAAAGGCCTCGGTGCTCGTTTGGAACGTGCTATCTACAAC
    TTTATGTTGGATGAACATGGAAAAGAAGGCTATACTGAAGTCATCACACCTTACATAGTC
    AACCATGATTCTATGTTTGGTACTGGTCAGTATCCAAAATTTAAGGAAGATACTTTTGAA
    CTCAGCGATACCAACTTTGTCTTGATTCCAACTGCTGAAGTTCCTCTGACAAACTACTAC
    CGTGATGAAATCTTAGACGGCAAAGATCTTCCAATCTACTTCACTGCTATGAGTCCGTCA
    TTCCGTTCTGAGGCTGGTTCTGCCGGTCGTGATACGCGTGGCTTGATCCGTTTGCACCAA
    TTCCACAAGGTTGAAATGGTCAAATTTGCCAAACCAGAAGAATCTTACGAAGAATTGGAA
    AAAATGACAGCCAACGCTGAAAACATTCTTCAAAAACTCAACCTTCCATACCGTGTCGTT
    GCTCTCTCTACTGGAGATATGGGCTTCTCAGCTACGAAGACTTACGACTTGGAAGTGTGG
    ATTCCAGCACAAAACAATTACCGTGAAATCTCAAGCTGTTCAAACACAGAAGATTTCCAA
    GCCCGTCGTGCCCAAATCCGTTACCGTGATGAAGCAGATGGCAAGGTGAAACTCCTTCAT
    ACCTTGAACGGTTCTGGACTTGCAGTTGGACGTACAGTGGCTGCAATTCTTGAAAATTAC
    CAAAATGAAGATGGTTCTGTGACCATCCCAGAAGCACTTCGTCCATACATGGGTGGAGCT
    GAAGTCATCAAACCATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1338

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: spr0372 [new locus tag: SPR_RS01905 ]
  • symbol: SerS
  • description: Seryl-tRNA synthetase
  • length: 445
  • theoretical pI: 4.8197
  • theoretical MW: 50094.2
  • GRAVY: -0.449888

⊟Function[edit | edit source]

  • reaction:
    EC 6.1.1.11?  ExPASy
    Serine--tRNA ligase ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser) ATP + L-serine + tRNA(Sec) = AMP + diphosphate + L-seryl-tRNA(Sec)
  • TIGRFAM:
    Genetic information processing Protein synthesis tRNA aminoacylation serine--tRNA ligase (TIGR00414; EC 6.1.1.11; HMM-score: 580.1)
    and 12 more
    Genetic information processing Protein synthesis tRNA aminoacylation threonine--tRNA ligase (TIGR00418; EC 6.1.1.3; HMM-score: 61.3)
    Genetic information processing Protein synthesis tRNA aminoacylation proline--tRNA ligase (TIGR00409; EC 6.1.1.15; HMM-score: 52.2)
    Genetic information processing Protein synthesis tRNA aminoacylation serine--tRNA ligase (TIGR00415; EC 6.1.1.11; HMM-score: 40.5)
    Genetic information processing Protein synthesis tRNA aminoacylation proline--tRNA ligase (TIGR00408; EC 6.1.1.15; HMM-score: 29.7)
    SH3 domain protein (TIGR04211; HMM-score: 26.9)
    Genetic information processing DNA metabolism Restriction/modification DNA sulfur modification protein DndD (TIGR03185; HMM-score: 21.6)
    Cellular processes Cellular processes Cell division chromosome segregation protein SMC (TIGR02169; HMM-score: 16.7)
    Genetic information processing DNA metabolism Chromosome-associated proteins chromosome segregation protein SMC (TIGR02169; HMM-score: 16.7)
    Cellular processes Cellular processes Cell division chromosome segregation protein SMC (TIGR02168; HMM-score: 14)
    Genetic information processing DNA metabolism Chromosome-associated proteins chromosome segregation protein SMC (TIGR02168; HMM-score: 14)
    Genetic information processing Protein fate Protein folding and stabilization prefoldin, alpha subunit (TIGR00293; HMM-score: 10.9)
    Genetic information processing Protein synthesis tRNA aminoacylation glycine--tRNA ligase (TIGR00389; EC 6.1.1.14; HMM-score: 7.9)
  • TheSEED  :
    • Seryl-tRNA synthetase (EC 6.1.1.11)
    Amino Acids and Derivatives Alanine, serine, and glycine Glycine and Serine Utilization  Seryl-tRNA synthetase (EC 6.1.1.11)
    and 1 more
    Protein Metabolism Protein biosynthesis tRNA aminoacylation, Ser  Seryl-tRNA synthetase (EC 6.1.1.11)
  • PFAM:
    tRNA_synt_II (CL0040) tRNA-synt_2b; tRNA synthetase class II core domain (G, H, P, S and T) (PF00587; HMM-score: 126)
    tRNA_bind_arm (CL0298) Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain (PF02403; HMM-score: 110.6)
    and 16 more
    no clan defined Dynamitin; Dynamitin (PF04912; HMM-score: 15.1)
    Baculo_PEP_C; Baculovirus polyhedron envelope protein, PEP, C terminus (PF04513; HMM-score: 14.8)
    CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 (PF10473; HMM-score: 14.6)
    DUF3450; Protein of unknown function (DUF3450) (PF11932; HMM-score: 14.1)
    DUF641; Plant protein of unknown function (DUF641) (PF04859; HMM-score: 13.5)
    ING; Inhibitor of growth proteins N-terminal histone-binding (PF12998; HMM-score: 12.9)
    UBC (CL0208) Knl1_RWD_C; Knl1 RWD C-terminal domain (PF18210; HMM-score: 12.8)
    no clan defined TMPIT; TMPIT-like protein (PF07851; HMM-score: 12.6)
    TMF_TATA_bd; TATA element modulatory factor 1 TATA binding (PF12325; HMM-score: 12.5)
    AT14A-like (CL0133) DUF677; Protein of unknown function (DUF677) (PF05055; HMM-score: 12.2)
    no clan defined DUF4407; Domain of unknown function (DUF4407) (PF14362; HMM-score: 11.3)
    BLOC1_2; Biogenesis of lysosome-related organelles complex-1 subunit 2 (PF10046; HMM-score: 11.1)
    DUF2203; Uncharacterized conserved protein (DUF2203) (PF09969; HMM-score: 10.8)
    DUF4763; Domain of unknown function (DUF4763) (PF15960; HMM-score: 9.9)
    NPV_P10; Nucleopolyhedrovirus P10 protein (PF05531; HMM-score: 9.8)
    DUF1843; Domain of unknown function (DUF1843) (PF08898; HMM-score: 7.7)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 10
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9991
    • Cytoplasmic Membrane Score: 0
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0009
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.003911
    • TAT(Tat/SPI): 0.000354
    • LIPO(Sec/SPII): 0.001929
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MEPWPCHSNVLSGCFFHKGVLMLDIKRIRTDFEAVAEKLATRGVDAAVLNEMKEIDAKRRNILVKVETLKAERNTVSAEIAQAKRNKENTDDKIAAMQNLSAEVKALDAELAEIDAKLTEFTTTLPNIPADSVPVGADEDDNVEVRRWGTPREFDFEPKAHWDLGEDLGILDWERGGKVTGARFLFYKGLGARLERAIYNFMLDEHGKEGYTEVITPYIVNHDSMFGTGQYPKFKEDTFELSDTNFVLIPTAEVPLTNYYRDEILDGKDLPIYFTAMSPSFRSEAGSAGRDTRGLIRLHQFHKVEMVKFAKPEESYEELEKMTANAENILQKLNLPYRVVALSTGDMGFSATKTYDLEVWIPAQNNYREISSCSNTEDFQARRAQIRYRDEADGKVKLLHTLNGSGLAVGRTVAAILENYQNEDGSVTIPEALRPYMGGAEVIKP

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ Jane A Thanassi, Sandra L Hartman-Neumann, Thomas J Dougherty, Brian A Dougherty, Michael J Pucci
    Identification of 113 conserved essential genes using a high-throughput gene disruption system in Streptococcus pneumoniae.
    Nucleic Acids Res: 2002, 30(14);3152-62
    [PubMed:12136097] [WorldCat.org] [DOI] (I p)

⊟Relevant publications[edit | edit source]

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