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PangenomeTIGR4
serotype 4
D39serotype 2
D39Vserotype 2
Hungary19A-6serotype 19A
EF3030serotype 19F
670-6Bserotype 6B
6A-10serotype 6A
70585serotype 5
A026serotype 19F
A66serotype 3
AP200serotype 11A
ASP0581serotype 12F
ATCC 49619serotype 19F
ATCC 700669serotype 23F
BM6001serotype 19F
BVJ1JLserotype 1
CGSP14serotype 14
G54serotype 19F
HU-OHserotype 3
Hu15serotype 19A
Hu17serotype 19A
INV104serotype 1
INV200serotype 14
JJAserotype 14
MDRSPN001serotype 19F
NCTC7465serotype 1
NCTC7466serotype 2
NU83127serotype 4
OXC141serotype 3
P1031serotype 1
R6serotype 2
SP49serotype 19A
SPN032672serotype 1
SPN034156serotype 3
SPN034183serotype 3
SPN994038serotype 3
SPN994039serotype 3
SPNA45serotype 3
ST556serotype 19F
TCH8431/19Aserotype 19A
Taiwan19F-14serotype 19F
Xen35serotype 4
gamPNI0373serotype 1
NCBI: 30-JAN-2014
⊟Summary[edit | edit source]
- organism: Streptococcus pneumoniae R6
- locus tag: spr0649 [new locus tag: SPR_RS03265 ]
- pan locus tag?: PNEUPAN001677000
- symbol: mta
- pan gene symbol?: mta
- synonym:
- product: Regulator of the multidrug efflux pump pmrA
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: spr0649 [new locus tag: SPR_RS03265 ]
- symbol: mta
- product: Regulator of the multidrug efflux pump pmrA
- replicon: chromosome
- strand: +
- coordinates: 656131..656793
- length: 663
- essential: unknown
⊟Accession numbers[edit | edit source]
- Location: AE007317 (656131..656793) NCBI
- BioCyc: SPR0649 BioCyc
- MicrobesOnline: 133534 MicrobesOnline
- PneumoBrowse for strain D39V: SPV_0643 PneumoBrowse
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
- 1
61
121
181
241
301
361
421
481
541
601
661TTGGTCCCCTTAAAGTCGGAAAACGGCTATCGAACCTATAGTCAAGAGGATTTGGAACGC
CTTCAGGTCATTCTTTACTACAAATATCTAGGCTTTTCTTTAGAGAAAATAGCAGAGCTG
TTAAAGGAAGAAAGGACAGATTTATTGCCCCATTTAACTAGGCAGTTGGACTATCTAACT
CGCGAAAGGCAACATCTGGATACCTTGATTTCCACCTTGCAAAAAACTATTCAAGAACAA
AAAGGAGAAAGAAAAATGACCATTGAGGAAAAATTCACGGGATTTAGCTATCAAGACAAT
CAAAAATACCACCAAGAAGCGGTAGAGAAATATGGTCAAGAAGTCATGGGACAAGCGCTC
GAACGCCAAAAAGGTCACGAAGACGAGGCTACGGCCGCCTTTAACCAAGTCTTTCAAACT
TTGGCACAAAATCTTCAAGTTGGTTTACCTGCAACAGCAACCGAAAACCAAGAGCAAGCA
GCCAAGCTCTTGCAAGCTATTCGCACTTATGGATTTGACTGCTCTATTGAGGTATTCGGT
CATATCGGTAAAGGTTACGTCTACAACCCAGAGTTTAAGGAAAATATTGACAAGTTTGGT
TCTGAAACAGCCCAGTACACGTCAGATGCCATTGCGGCTTACGTTCAGACAAATGCAGAA
TAA60
120
180
240
300
360
420
480
540
600
660
663
⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: spr0649 [new locus tag: SPR_RS03265 ]
- symbol: Mta
- description: Regulator of the multidrug efflux pump pmrA
- length: 220
- theoretical pI: 4.81221
- theoretical MW: 25400.2
- GRAVY: -0.712273
⊟Function[edit | edit source]
- TIGRFAM: Regulatory functions DNA interactions Cu(I)-responsive transcriptional regulator (TIGR02044; HMM-score: 36.1)Cellular processes Detoxification Hg(II)-responsive transcriptional regulator (TIGR02051; HMM-score: 34.5)Regulatory functions DNA interactions Hg(II)-responsive transcriptional regulator (TIGR02051; HMM-score: 34.5)Regulatory functions DNA interactions Zn(II)-responsive transcriptional regulator (TIGR02043; HMM-score: 33.1)and 2 moreRegulatory functions DNA interactions Cd(II)/Pb(II)-responsive transcriptional regulator (TIGR02047; HMM-score: 21.7)4-nitrotryptophan synthase (TIGR04458; EC 1.-.-.-; HMM-score: 12.1)
- TheSEED :
- Regulator of the multidrug efflux pump pmrA
- PFAM: no clan defined TipAS; TipAS antibiotic-recognition domain (PF07739; HMM-score: 74.6)and 7 moreHTH (CL0123) MerR-DNA-bind; MerR, DNA binding (PF09278; HMM-score: 37.2)MerR_1; MerR HTH family regulatory protein (PF13411; HMM-score: 33.5)no clan defined Enkurin; Calmodulin-binding (PF13864; HMM-score: 16)DNA_primase_lrg (CL0242) DNA_primase_lrg; Eukaryotic and archaeal DNA primase, large subunit (PF04104; HMM-score: 13.1)PDDEXK (CL0236) VRR_NUC; VRR-NUC domain (PF08774; HMM-score: 12.7)no clan defined DUF2203; Uncharacterized conserved protein (DUF2203) (PF09969; HMM-score: 10.9)STAT_int; STAT protein, protein interaction domain (PF02865; HMM-score: 10.4)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb: Cytoplasmic
- Cytoplasmic Score: 7.5
- Cytoplasmic Membrane Score: 1.15
- Cellwall Score: 0.62
- Extracellular Score: 0.73
- Internal Helices: 0
- DeepLocPro: Cytoplasmic
- Cytoplasmic Score: 0.9945
- Cytoplasmic Membrane Score: 0.0007
- Cell wall & surface Score: 0.0004
- Extracellular Score: 0.0044
- SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.000886
- TAT(Tat/SPI): 0.000168
- LIPO(Sec/SPII): 0.000211
- predicted transmembrane helices (TMHMM): 0
⊟Accession numbers[edit | edit source]
⊟Protein sequence[edit | edit source]
- MVPLKSENGYRTYSQEDLERLQVILYYKYLGFSLEKIAELLKEERTDLLPHLTRQLDYLTRERQHLDTLISTLQKTIQEQKGERKMTIEEKFTGFSYQDNQKYHQEAVEKYGQEVMGQALERQKGHEDEATAAFNQVFQTLAQNLQVGLPATATENQEQAAKLLQAIRTYGFDCSIEVFGHIGKGYVYNPEFKENIDKFGSETAQYTSDAIAAYVQTNAE
⊟Experimental data[edit | edit source]
- protein localization:
- interaction partners:
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
- MicrobesOnline: no polycistronic organisation predicted
⊟Regulation[edit | edit source]
- regulator:
⊟Transcription[edit | edit source]
- transcription start site:
⊟Expression data[edit | edit source]
- PneumoExpress for strain D39V: SPV_0643 PneumoExpress
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
You can add further information about the gene and protein here. [edit]