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serotype 1
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SPN032672
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SPN034183
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SPN994038
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Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 30-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae R6
  • locus tag: spr0716 [new locus tag: SPR_RS03605 ]
  • pan locus tag?: PNEUPAN001758000
  • symbol: ezrA
  • pan gene symbol?: ezrA
  • synonym:
  • product: Cell division regulator, negative regulator of FtsZ ring formation

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: spr0716 [new locus tag: SPR_RS03605 ]
  • symbol: ezrA
  • product: Cell division regulator, negative regulator of FtsZ ring formation
  • replicon: chromosome
  • strand: +
  • coordinates: 717819..719573
  • length: 1755
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    TTGTTTCAAGTAAAAAAGGAGTTTGATATGTCTAATGGACAACTAATTTATTTAATGGTT
    GCAATTGCAGTCATTTTAGTTCTGGCTTATGTAGTGGCAATCTTTCTACGTAAGCGAAAC
    GAGGGGAGATTAGAGGCGCTAGAAGAAAGAAAAGAAGAACTATACAATCTTCCAGTAAAT
    GATGAAGTAGAAGCTGTAAAAAATATGCACTTGATTGGACAAAGTCAAGTGGCTTTCCGT
    GAATGGAATCAAAAATGGGTCGATTTATCTCTCAACTCTTTTGCCGATATTGAAAATAAT
    CTCTTTGAAGCAGAAGGCTATAACCATTCATTTCGTTTTCTCAAGGCCAGTCATCAAATT
    GACCAAATTGAGAGTCAAATTACTTTGATTGAAGAAGATATTGCGGCAATTCGCAATGCT
    TTGGCAGACTTAGAGAAGCAAGAATCTAAAAATAGTGGTCGTGTTCTTCATGCTTTGGAT
    TTATTTGAGGAACTTCAGCATAGAGTTGCTGAAAATTCAGAACAGTATGGTCAAGCCTTG
    GATGAAATTGAAAAACAATTAGAAAATATCCAATCTGAATTTTCACAATTTGTAACCTTG
    AATTCATCGGGTGACCCTGTGGAAGCCGCAGTGATTTTGGATAATACAGAAAATCACATT
    TTGGCCTTAAGTCATATTGTGGATCGTGTTCCAGCCTTGGTTACGACGCTTTCTACAGAA
    TTGCCAGATCAATTACAGGATTTGGAAGCCGGTTATCGTAAACTAATTGATGCTAATTAT
    CATTTTGTTGAAACGGATATTGAAGCGCGTTTCCACTTGCTTTATGAAGCATTCAAGAAA
    AACCAAGAGAATATTCGTCAGTTGGAATTGGATAATGCCGAATATGAGAATGGACAGGCA
    CAAGAGGAAATCAATGCCTTGTATGATATTTTTACTCGAGAAATTGCTGCTCAGAAAGTA
    GTGGAAAATCTACTTGCAACTCTTCCAACTTACCTTCAACATATGAAAGAGAATAATACT
    TTATTGGGAGAAGATATTGCACGTTTGAACAAGACCTATTTACTTCCTGAGACAGCTGCA
    AGCCATGTTCGTCGTATTCAGACAGAATTAGAGAGTTTTGAGGCAGCTATTGTTGAGGTA
    ACTTCAAATCAAGAAGAACCAACCCAAGCTTATTCAGTTCTTGAAGAAAATCTTGAGGAT
    TTACAAACTCAACTAAAAGATATTGAAGATGAGCAAATTTCAGTTAGTGAGCGCCTGACA
    CAAATTGAGAAAGATGATATTAATGCACGTCAAAAGGCCAATGTTTATGTCAATCGTCTC
    CATACTATCAAGCGATACATGGAAAAACGCAATCTGCCAGGTATTCCACAAACTTTCTTG
    AAGTTATTCTTTACGGCAAGCAATAATACCGAGGATTTAATGGTTGAGTTAGAACAAAAA
    ATGATTAACATTGAATCTGTTACCCGAGTTCTTGAAATTGCAACGAATGATATGGAAGCT
    TTAGAAACGGAAACTTATAATATTGTACAATATGCAACTTTGACAGAGCAACTCTTGCAA
    TATTCTAACCGCTATCGCTCATTTGATGAACGCATTCAAGAAGCATTTAACGAAGCTTTA
    GATATTTTTGAAAAAGAATTTGATTATCACGCTTCATTTGACAAGATTTCTCAAGCATTG
    GAAGTGGCAGAGCCTGGTGTAACCAATCGCTTTGTTACCTCATATGAGAAAACACGTGAA
    ACGATTCGTTTTTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1755

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: spr0716 [new locus tag: SPR_RS03605 ]
  • symbol: EzrA
  • description: Cell division regulator, negative regulator of FtsZ ring formation
  • length: 584
  • theoretical pI: 4.30048
  • theoretical MW: 67673.3
  • GRAVY: -0.442123

⊟Function[edit | edit source]

  • TIGRFAM:
    Cellular processes Cellular processes Cell division chromosome segregation protein SMC (TIGR02168; HMM-score: 20.9)
    Genetic information processing DNA metabolism Chromosome-associated proteins chromosome segregation protein SMC (TIGR02168; HMM-score: 20.9)
    and 9 more
    Cellular processes Cellular processes Cell division chromosome segregation protein SMC (TIGR02169; HMM-score: 16.5)
    Genetic information processing DNA metabolism Chromosome-associated proteins chromosome segregation protein SMC (TIGR02169; HMM-score: 16.5)
    Metabolism Energy metabolism Other tetrahydromethanopterin S-methyltransferase, subunit G (TIGR01149; EC 2.1.1.86; HMM-score: 11)
    Cellular processes Cellular processes Adaptations to atypical conditions phage shock protein C (TIGR02978; HMM-score: 9.4)
    WXG100 family type VII secretion target (TIGR03930; HMM-score: 8.2)
    two transmembrane protein (TIGR04527; HMM-score: 7.6)
    Cellular processes Cellular processes Sporulation and germination stage III sporulation protein AB (TIGR02833; HMM-score: 6)
    helix-rich protein (TIGR04523; HMM-score: 5.6)
    SH3 domain protein (TIGR04211; HMM-score: 5.2)
  • TheSEED  :
    • Septation ring formation regulator EzrA
    Cell Division and Cell Cycle Cell Division and Cell Cycle - no subcategory Control of cell elongation - division cycle in Bacilli  Septation ring formation regulator EzrA
  • PFAM:
    no clan defined EzrA; Septation ring formation regulator, EzrA (PF06160; HMM-score: 594.7)
    and 13 more
    SNARE-fusion (CL0445) Syntaxin; Syntaxin (PF00804; HMM-score: 19.6)
    Prefoldin (CL0200) Prefoldin_2; Prefoldin subunit (PF01920; HMM-score: 17.7)
    no clan defined DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1) (PF05454; HMM-score: 12.2)
    Tropomyosin-lke (CL0452) CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels (PF16526; HMM-score: 11.7)
    no clan defined Rx_N; Rx N-terminal domain (PF18052; HMM-score: 10.3)
    EsxAB (CL0352) WXG100; Proteins of 100 residues with WXG (PF06013; HMM-score: 10.1)
    no clan defined TPD52; Tumour protein D52 family (PF04201; HMM-score: 9.6)
    Pec_lyase-like (CL0268) FapA; Flagellar Assembly Protein A beta solenoid domain (PF03961; HMM-score: 8.9)
    no clan defined Uso1_p115_C; Uso1 / p115 like vesicle tethering protein, C terminal region (PF04871; HMM-score: 8.9)
    MtrG; Tetrahydromethanopterin S-methyltransferase, subunit G (PF04210; HMM-score: 7.8)
    ATG16; Autophagy protein 16 (ATG16) (PF08614; HMM-score: 6.8)
    Med9; RNA polymerase II transcription mediator complex subunit 9 (PF07544; HMM-score: 6.6)
    ISG65-75; Invariant surface glycoprotein (PF11727; HMM-score: 6.2)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.94
    • Cytoplasmic Membrane Score: 2.06
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helix: 1
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.0003
    • Cytoplasmic Membrane Score: 0.9967
    • Cell wall & surface Score: 0.0001
    • Extracellular Score: 0.0029
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.00864
    • TAT(Tat/SPI): 0.000396
    • LIPO(Sec/SPII): 0.001854
  • predicted transmembrane helices (TMHMM): 1

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MFQVKKEFDMSNGQLIYLMVAIAVILVLAYVVAIFLRKRNEGRLEALEERKEELYNLPVNDEVEAVKNMHLIGQSQVAFREWNQKWVDLSLNSFADIENNLFEAEGYNHSFRFLKASHQIDQIESQITLIEEDIAAIRNALADLEKQESKNSGRVLHALDLFEELQHRVAENSEQYGQALDEIEKQLENIQSEFSQFVTLNSSGDPVEAAVILDNTENHILALSHIVDRVPALVTTLSTELPDQLQDLEAGYRKLIDANYHFVETDIEARFHLLYEAFKKNQENIRQLELDNAEYENGQAQEEINALYDIFTREIAAQKVVENLLATLPTYLQHMKENNTLLGEDIARLNKTYLLPETAASHVRRIQTELESFEAAIVEVTSNQEEPTQAYSVLEENLEDLQTQLKDIEDEQISVSERLTQIEKDDINARQKANVYVNRLHTIKRYMEKRNLPGIPQTFLKLFFTASNNTEDLMVELEQKMINIESVTRVLEIATNDMEALETETYNIVQYATLTEQLLQYSNRYRSFDERIQEAFNEALDIFEKEFDYHASFDKISQALEVAEPGVTNRFVTSYEKTRETIRF

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Aurore Fleurie, Sylvie Manuse, Chao Zhao, Nathalie Campo, Caroline Cluzel, Jean-Pierre Lavergne, Céline Freton, Christophe Combet, Sébastien Guiral, Boumediene Soufi, Boris Macek, Erkin Kuru, Michael S VanNieuwenhze, Yves V Brun, Anne-Marie Di Guilmi, Jean-Pierre Claverys, Anne Galinier, Christophe Grangeasse
Interplay of the serine/threonine-kinase StkP and the paralogs DivIVA and GpsB in pneumococcal cell elongation and division.
PLoS Genet: 2014, 10(4);e1004275
[PubMed:24722178] [WorldCat.org] [DOI] (I e)

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