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TIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 30-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae R6
  • locus tag: spr1259
  • pan locus tag?:
  • symbol: spr1259
  • pan gene symbol?: —
  • synonym:
  • product: Conserved hypothetical protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: spr1259
  • symbol: spr1259
  • product: Conserved hypothetical protein
  • replicon: chromosome
  • strand: -
  • coordinates: 1257581..1258384
  • length: 804
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: AE007317 (1257581..1258384) NCBI
  • BioCyc:
  • MicrobesOnline: 134143 MicrobesOnline
  • PneumoBrowse for strain D39V:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    ATGCAATTTCCAGAAGGATTTGTTGAAAAATATAAAGAGATACTAGGAGATGAGGCAAGA
    GATTTTCTTGCCTCTTTTGAGGAGGAAGCGGTTTCGGCCTTTCGGGTCAATCCCTTAAAA
    GAAGAGCAACTTTCCTTTTCTGATGCCATTACTCAAACCCCTTGGGGCCACTATGGGAAG
    GTTTCAGGGAAATCGCCTGAGCATGCTACAGGTTTAGTTTATTCGCAAGAACCTGCTGCT
    CAAATGGTGGCTCAAGTAGCCCAACCCAGTCCTGGTATGAAGGTCTTGGACTTGGCTGCT
    GCACCGGGGGGCAAATCAACTCAACTGGCAGCCTATCTAGCAGGTGAGGGGCTACTTGTT
    TCCAATGAAATTTCAAGCAAACGGGCTAAGATTTTGGTTGAAAACATGGAGCGTTTTGGA
    GCGACAAATGTCGTGGTGACCAATGAATCTGCCGACCGCTTGGTCAAGGTCTTTAAAGGC
    TATTTTGACTTAATCGTTCTTGATGCCCCTTGCTCTGGTGAAGGAATGTTTCGTAAGCAA
    CCTGATGCTATGGACTATTGGAGCTTAGATTATCCGAGTCAATGTGCTAGCTTGCAAAGA
    GAAATTCTGGAGGATGCAGTGACCATGTTAGCTGAAGGTGGTCGTCTGGTTTATTCGACC
    TGTACCTGGGCACCCGAGGAAAACGAAGAGATTGTCAATTGGTTGCTGGAAGAGTATGAT
    TTTGACTTGTTGCCAGTAGAGCATATCAATGGAATGGTAGCTGGTATTGACCTGCCAGAA
    ACGGCTCGGATGTACCCTTATTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    804

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: spr1259
  • symbol: spr1259
  • description: Conserved hypothetical protein
  • length: 267
  • theoretical pI: 4.16842
  • theoretical MW: 29538.2
  • GRAVY: -0.200749

⊟Function[edit | edit source]

  • TIGRFAM:
    Genetic information processing Protein synthesis tRNA and rRNA base modification NOL1/NOP2/sun family putative RNA methylase (TIGR00446; EC 2.1.1.-; HMM-score: 184.5)
    and 6 more
    Genetic information processing Protein synthesis tRNA and rRNA base modification 16S rRNA (cytosine(967)-C(5))-methyltransferase (TIGR00563; EC 2.1.1.176; HMM-score: 133.8)
    Genetic information processing Protein synthesis tRNA and rRNA base modification ribosomal RNA large subunit methyltransferase J (TIGR00438; EC 2.1.1.166; HMM-score: 22.5)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Heme, porphyrin, and cobalamin precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit (TIGR02469; EC 2.1.1.132; HMM-score: 18.7)
    methyltransferase, FxLD system (TIGR04364; HMM-score: 15.4)
    Genetic information processing Protein synthesis Ribosomal proteins: synthesis and modification protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific (TIGR03533; EC 2.1.1.-; HMM-score: 14.7)
    Genetic information processing Protein synthesis tRNA and rRNA base modification N2,N2-dimethylguanosine tRNA methyltransferase (TIGR00308; EC 2.1.1.-; HMM-score: 11.7)
  • TheSEED  :
    • tRNA/rRNA cytosine-C5-methyltransferase
  • PFAM:
    NADP_Rossmann (CL0063) Methyltr_RsmB-F; 16S rRNA methyltransferase RsmB/F (PF01189; HMM-score: 132.1)
    and 6 more
    Methyltr_RsmF_N; N-terminal domain of 16S rRNA methyltransferase RsmF (PF17125; HMM-score: 62.6)
    Methyltransf_31; Methyltransferase domain (PF13847; HMM-score: 28)
    FtsJ; FtsJ-like methyltransferase (PF01728; HMM-score: 24.5)
    PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) (PF01135; HMM-score: 14.2)
    TRM; N2,N2-dimethylguanosine tRNA methyltransferase (PF02005; HMM-score: 14.1)
    Methyltransf_25; Methyltransferase domain (PF13649; HMM-score: 13.1)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9861
    • Cytoplasmic Membrane Score: 0.0123
    • Cell wall & surface Score: 0.0002
    • Extracellular Score: 0.0014
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.010888
    • TAT(Tat/SPI): 0.002673
    • LIPO(Sec/SPII): 0.000847
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MQFPEGFVEKYKEILGDEARDFLASFEEEAVSAFRVNPLKEEQLSFSDAITQTPWGHYGKVSGKSPEHATGLVYSQEPAAQMVAQVAQPSPGMKVLDLAAAPGGKSTQLAAYLAGEGLLVSNEISSKRAKILVENMERFGATNVVVTNESADRLVKVFKGYFDLIVLDAPCSGEGMFRKQPDAMDYWSLDYPSQCASLQREILEDAVTMLAEGGRLVYSTCTWAPEENEEIVNWLLEEYDFDLLPVEHINGMVAGIDLPETARMYPY

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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