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PangenomeTIGR4
serotype 4
D39serotype 2
D39Vserotype 2
Hungary19A-6serotype 19A
EF3030serotype 19F
670-6Bserotype 6B
6A-10serotype 6A
70585serotype 5
A026serotype 19F
A66serotype 3
AP200serotype 11A
ASP0581serotype 12F
ATCC 49619serotype 19F
ATCC 700669serotype 23F
BVJ1JLserotype 1
CGSP14serotype 14
G54serotype 19F
HU-OHserotype 3
Hu15serotype 19A
Hu17serotype 19A
INV104serotype 1
INV200serotype 14
JJAserotype 14
MDRSPN001serotype 19F
NCTC7466serotype 2
NU83127serotype 4
OXC141serotype 3
P1031serotype 1
R6serotype 2
SP49serotype 19A
SPN032672serotype 1
SPN034156serotype 3
SPN034183serotype 3
SPN994038serotype 3
SPN994039serotype 3
SPNA45serotype 3
ST556serotype 19F
TCH8431/19Aserotype 19A
Taiwan19F-14serotype 19F
Xen35serotype 4
gamPNI0373serotype 1
NCBI: 19-NOV-2015
⊟Summary[edit | edit source]
- organism: Streptococcus pneumoniae A66
- locus tag: A66_00090 [new locus tag: A66_RS00450 ]
- pan locus tag?: PNEUPAN000734000
- symbol: A66_00090
- pan gene symbol?: pavB
- synonym:
- product: Cell wall surface anchor family protein
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: A66_00090 [new locus tag: A66_RS00450 ]
- symbol: A66_00090
- product: Cell wall surface anchor family protein
- replicon: chromosome
- strand: +
- coordinates: 82936..83964
- length: 1029
- essential: unknown
⊟Accession numbers[edit | edit source]
- Location: LN847353 (82936..83964) NCBI
- BioCyc:
- MicrobesOnline:
- PneumoBrowse for strain D39V: SPV_0080 PneumoBrowse
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
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1021ATGAAATTCAATCCAAATCAAAGATATACTCGTTGGTCTATTCGCCGTCTCAGTGTCGGT
GTTGCCTCAGTTGTTGTGGCTAGTGGCTTCTTTGTCCTAGTTGGTCAGCCAAGTTCTGTA
CGTGCCGATGTGGTCAATCCGACCCCAGGTCAAGTCTTACCTGAAGAGACATCGGGAACG
AAAGAGGGTGACTTATCAGAAAAACCAGGAGACACCGTTCTCACTCAAGCGAAACCTGAG
GGCGTTACTGGAAATACGAATTCACTTCCGACACCTACAGAAAGAACTGAAGTGAGCGAG
GAAACAAACTCTTCTAGTCTGGATACACTTTTTGAAAAAGATGAAGAAGCTCAAAAAAAT
CCAGAGCTAACAGATGTCTTAAAAGAAACTGTAGATACAGCTGATGTGGATGGGACACAA
GCAAGTCCAGCAGAAACTACTCCTGAACAAGTAAAAGGTGGAGTGAAAGAAAATACAAAA
GACAGCATCGATGTTCCTGCTGCTTATCTTGAAAAAGCTGAAGGGAAAGGTCCTTTCACT
GCCGGTGTAAACCAAGTAATTCCTTATGAACTATTCGCTGGTGATGGTATGTTAACTCGT
CTATTACTAAAAGCTTCGGATAATGCTCCTTGGTCTGACAATGGTACTGCTAAAAATCCT
GCTTTACCTCCTCTTGAAGGATTAACAAAAGGGAAATACTTCTATGAAGTAGACTTAAAT
GGCAATACTGTTGGTAAACAAGGTCAAGCTTTAATTGATCAACTTCGCGCTAATGGTACT
CAAACTTATAAAGCTACTGTTAAAGTTTACGGAAATAAAGACGGTAAAGCTGACTTGACT
AATCTAGTTGCTACTAAAAATGTAGACATCAACATCAATGGATTAGTTGCTAAAGAAACT
GTCGAAAAAGCTGTTAAAGATAACGTTAAAGACAGTATCGATGTTCCAGCAGCCTACCTA
GAAAAAGCCAAGGGTGAAGGTCCATTCACAGCAGGTGTCAACCATGTGATTCCATACGAA
CTCTTCTAA60
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⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: A66_00090 [new locus tag: A66_RS00450 ]
- symbol: A66_00090
- description: Cell wall surface anchor family protein
- length: 342
- theoretical pI: 4.50986
- theoretical MW: 36558.5
- GRAVY: -0.50117
⊟Function[edit | edit source]
- TIGRFAM: gram-positive signal peptide, YSIRK family (TIGR01168; HMM-score: 47.2)
- TheSEED: data available for D39, Hungary19A-6, TIGR4
- PFAM: no clan defined SSURE; SSURE domain (PF11966; HMM-score: 343.8)and 2 moreYSIRK_signal; YSIRK type signal peptide (PF04650; HMM-score: 30.6)USP47_C; Ubiquitin carboxyl-terminal hydrolase 47 C-terminal (PF19718; HMM-score: 13.2)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb: unknown (no significant prediction)
- Cytoplasmic Score: 2.5
- Cytoplasmic Membrane Score: 2.5
- Cellwall Score: 2.5
- Extracellular Score: 2.5
- Internal Helix: 1
- SignalP: Signal peptide SP(Sec/SPI) length 42 aa
- SP(Sec/SPI): 0.930917
- TAT(Tat/SPI): 0.064848
- LIPO(Sec/SPII): 0.001806
- Cleavage Site: CS pos: 42-43. VRA-DV. Pr: 0.9799
- predicted transmembrane helices (TMHMM): 1
⊟Accession numbers[edit | edit source]
- GI:
- RefSeq: CRI60801 NCBI
- UniProt:
⊟Protein sequence[edit | edit source]
- MKFNPNQRYTRWSIRRLSVGVASVVVASGFFVLVGQPSSVRADVVNPTPGQVLPEETSGTKEGDLSEKPGDTVLTQAKPEGVTGNTNSLPTPTERTEVSEETNSSSLDTLFEKDEEAQKNPELTDVLKETVDTADVDGTQASPAETTPEQVKGGVKENTKDSIDVPAAYLEKAEGKGPFTAGVNQVIPYELFAGDGMLTRLLLKASDNAPWSDNGTAKNPALPPLEGLTKGKYFYEVDLNGNTVGKQGQALIDQLRANGTQTYKATVKVYGNKDGKADLTNLVATKNVDININGLVAKETVEKAVKDNVKDSIDVPAAYLEKAKGEGPFTAGVNHVIPYELF
⊟Experimental data[edit | edit source]
- protein localization:
- interaction partners:
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
⊟Regulation[edit | edit source]
- regulator:
⊟Expression data[edit | edit source]
- PneumoExpress for strain D39V: SPV_0080 PneumoExpress
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
You are kindly invited to share additional interesting facts.
⊟Literature[edit | edit source]
⊟References[edit | edit source]
⊟Relevant publications[edit | edit source]
Inga Jensch, Gustavo Gámez, Michael Rothe, Sandra Ebert, Marcus Fulde, Daniela Somplatzki, Simone Bergmann, Lothar Petruschka, Manfred Rohde, Roland Nau, Sven Hammerschmidt
PavB is a surface-exposed adhesin of Streptococcus pneumoniae contributing to nasopharyngeal colonization and airways infections.
Mol Microbiol: 2010, 77(1);22-43
[PubMed:20444103] [WorldCat.org] [DOI] (I p)Ulrike Binsker, Thomas P Kohler, Krystin Krauel, Sylvia Kohler, Hansjörg Schwertz, Sven Hammerschmidt
Pneumococcal Adhesins PavB and PspC Are Important for the Interplay with Human Thrombospondin-1.
J Biol Chem: 2015, 290(23);14542-55
[PubMed:25897078] [WorldCat.org] [DOI] (I p)Sajida Kanwal, Inga Jensch, Gottfried J Palm, Mark Brönstrup, Manfred Rohde, Thomas P Kohler, Daniela Somplatzki, Werner Tegge, Howard F Jenkinson, Sven Hammerschmidt
Mapping the recognition domains of pneumococcal fibronectin-binding proteins PavA and PavB demonstrates a common pattern of molecular interactions with fibronectin type III repeats.
Mol Microbiol: 2017, 105(6);839-859
[PubMed:28657670] [WorldCat.org] [DOI] (I p)