PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 19-NOV-2015

⊟Summary

• organism: Streptococcus pneumoniae A66
• locus tag: A66_00381 [new locus tag: A66_RS01915 ]
• pan locus tag^?: PNEUPAN001267000
• symbol: A66_00381
• pan gene symbol^?: mtlD
• synonym:
• product: Mannitol-1-phosphate 5-dehydrogenase

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: A66_00381 [new locus tag: A66_RS01915 ]
• symbol: A66_00381
• product: Mannitol-1-phosphate 5-dehydrogenase
• replicon: chromosome
• strand: +
• coordinates: 361599..362735
• length: 1137
• essential: unknown

⊟Accession numbers

• Location: LN847353 (361599..362735) NCBI
• BioCyc:
• MicrobesOnline:
• PneumoBrowse for strain D39V: SPV_0363 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  721
  781
  841
  901
  961
  1021
  1081
  
  ATGAAACATTCTGTTCATTTTGGTGCCGGTAATATCGGTCGTGGTTTTATAGGTGAAATT
  CTATTTAAAAATGGTTTCCATATTGATTTTGTGGATGTCAATAATCAGATAATTCATGCT
  CTAAATGAAAAGGGCAAGTATGAAATTGAAATTGCACAGAAAGGACAGTCTCGTATAGAA
  GTAACTAATGTGGCTGGCATTAATAGCAAAGAACATCCTGAGCAAGTCATTGAAGCGATT
  CAAAAGACGGATATTATTACTACTGCAATCGGACCTAATATACTCCCTTTTATCGCCGAA
  CTTCTAGCCAAAGGAATCGAAGCTCGCCGAGTTGCAGGAAATACACAGGCATTGGATGTT
  ATGGCCTGTGAAAATATGATTGGCGGGTCTCAATTTCTTTATCAAGAAGTCAAGAAATAT
  TTAAGTCCGGAAGGTTTGACATTTGCTGATAACTACATAGGTTTTCCAAATGCTGCAGTA
  GACAGGATTGTTCCAGCACAAAGTCACGAAGATTCCCTTTTTGTTGTGGTCGAGCCCTTT
  AATGAATGGGTCGTGGAAACCAAGCGTCTTAAAAATCCAGATTTACGTCTAAAAGATGTG
  CATTATGAAGAAGATTTAGAACCCTTTATTGAGCGAAAACTTTTTTCAGTCAATTCTGGA
  CATGCAACTTCAGCTTACATTGGTGCGCATTATGGTGCCAAGACAATTTTGGAAGCTCTT
  CAAAATCCTAATATTAAATCTCGGATTGAATCTGTATTAGCTGAAATTCGGAGTCTCTTG
  ATTGCCAAATGGAACTTTGATAAAAAAGAATTGGAGAATTATCACAAAGTCATTATAGAA
  CGGTTTGAAAACCCTTTCATAGTGGACGAGGTTAGTCGCGTAGCTCGTACTCCAATCCGA
  AAATTAGGCTATAATGAACGATTCATCCGGCCGATACGTGAATTGAAAGAACTCAGTTTG
  TCATATAAAAACCTACTTAAAACAGTTGGCTATGCCTTTGACTATCGCGATGTAAATGAT
  GAAGAAAGTATGCGATTAGGTGAATTGTTGGCTAAACAATCAGTCAAAGATGTTGTTATA
  CAAGTTACAGGTTTAGACGACCAAGAATTGATTGAGCAAATTGTAGAGTATATTTAA
  60
  120
  180
  240
  300
  360
  420
  480
  540
  600
  660
  720
  780
  840
  900
  960
  1020
  1080
  1137
  

⊟Protein

⊟General

• locus tag: A66_00381 [new locus tag: A66_RS01915 ]
• symbol: A66_00381
• description: Mannitol-1-phosphate 5-dehydrogenase
• length: 378
• theoretical pI: 5.4995
• theoretical MW: 42954.7
• GRAVY: -0.238095

⊟Function

• reaction:
  EC 1.1.1.17?  ExPASy
  Mannitol-1-phosphate 5-dehydrogenase D-mannitol 1-phosphate + NAD⁺ = D-fructose 6-phosphate + NADH
• TIGRFAM:
  Cellular processes Cellular processes Toxin production and resistance radical SAM P-methyltransferase, PhpK family (TIGR04479; EC 2.1.-.-; HMM-score: 13.1)
• TheSEED: data available for D39, Hungary19A-6, TIGR4
• PFAM:
  6PGD_C (CL0106) Mannitol_dh_C; Mannitol dehydrogenase C-terminal domain (PF08125; HMM-score: 208.8)
  and 4 more
  NADP_Rossmann (CL0063) Mannitol_dh; Mannitol dehydrogenase Rossmann domain (PF01232; HMM-score: 99.4)
  no clan defined CofD; 2-phospho-L-lactate transferase CofD (PF01933; HMM-score: 18.5)
  NADP_Rossmann (CL0063) UDPG_MGDP_dh_N; UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain (PF03721; HMM-score: 15.4)
  Transthyretin (CL0287) CooC_C; CS1-pili formation C-terminal (PF15976; HMM-score: 12.4)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cytoplasmic
  • Cytoplasmic Score: 9.97
  • Cytoplasmic Membrane Score: 0
  • Cellwall Score: 0.01
  • Extracellular Score: 0.02
  • Internal Helices: 0
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.00466
  • TAT(Tat/SPI): 0.000202
  • LIPO(Sec/SPII): 0.000372
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: CRI61092 NCBI
• UniProt:

⊟Protein sequence

• MKHSVHFGAGNIGRGFIGEILFKNGFHIDFVDVNNQIIHALNEKGKYEIEIAQKGQSRIEVTNVAGINSKEHPEQVIEAIQKTDIITTAIGPNILPFIAELLAKGIEARRVAGNTQALDVMACENMIGGSQFLYQEVKKYLSPEGLTFADNYIGFPNAAVDRIVPAQSHEDSLFVVVEPFNEWVVETKRLKNPDLRLKDVHYEEDLEPFIERKLFSVNSGHATSAYIGAHYGAKTILEALQNPNIKSRIESVLAEIRSLLIAKWNFDKKELENYHKVIIERFENPFIVDEVSRVARTPIRKLGYNERFIRPIRELKELSLSYKNLLKTVGYAFDYRDVNDEESMRLGELLAKQSVKDVVIQVTGLDDQELIEQIVEYI

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• data available for TIGR4

⊟Expression data

• PneumoExpress for strain D39V: SPV_0363 PneumoExpress

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications