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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 19-NOV-2015

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae A66
  • locus tag: A66_01518 [new locus tag: A66_RS07545 ]
  • pan locus tag?: PNEUPAN003112000
  • symbol: A66_01518
  • pan gene symbol?: nanA
  • synonym:
  • product: Sialidase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: A66_01518 [new locus tag: A66_RS07545 ]
  • symbol: A66_01518
  • product: Sialidase
  • replicon: chromosome
  • strand: -
  • coordinates: 1459597..1462425
  • length: 2829
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: LN847353 (1459597..1462425) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1504 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    2281
    2341
    2401
    2461
    2521
    2581
    2641
    2701
    2761
    2821
    ATGATTGTAGGAGCAGTGGTATTTGGAACGTCTCCTGTTTTAGCTCAAGAAGGGGCAAGT
    GAGCAACCTCTGGCAAATGAAACTCAACTTTCGGGGGGGAGCTCAACCCTAACTGATACA
    GAAAAGAGCCAGCCTTCTTCAGAGACTGAACTTTCTGGCAATAAGCAAGAACAAGAAAGG
    AAAGATAAGCAAGAAGAAAAAATTCCAAGAGATTACTATGCACGAGATTTGGAAAATGTC
    GAAACAGTGATAGAAAAAGAAGATGTTGAAACCAATGCTTCAAATGGTCAGAGAGTTGAT
    TTATCAAGTGAACTAGATAAACTAAAGAAACTTGAAAACGCAACAGTTCACATGGAGTTT
    AAGCCAGATGCCAAGGCCCCAGCATTCTATAATCTCTTTTCTGTGTCAAGTGCTACTAAA
    AAAGATGAGTACTTCACTATGGCAGTTTACAATAATACTGCTACTCTAGAGGGGCGTGGT
    TCGGATGGGAAACAGTTTTACAATAATTACAACGATGCACCCTTAAAAGTTAAACCAGGT
    CAGTGGAATTCTGTGACTTTCACAGTTGAAAAACCGACAGCAGAACTACCTAAAGGCCGA
    GTGCGCCTCTACGTAAACGGGGTATTATCTCGAACAAGTCTGAGATCTGGCAATTTCATT
    AAAGATATGCCAGATGTAACGCATGTGCAAATCGGAGCAACCAAGCGTGCCAACAATACG
    GTTTGGGGGTCAAATCTACAGATTCGGAATCTCACTGTGTATAATCGTGCTTTAACACCA
    GAAGAGGTACAAAAACGTAGTCAACTTTTTAAACGCTCAGATTTAGAAAAAAAACTACCT
    GAAGGAGCGGCTTTAACAGAGAAAACGGACATATTCGAAAGCGGGCGTAACGGTAACCCA
    AATAAAGATGGAATCAAGAGTTATCGTATTCCAGCACTTCTCAAGACAGATAAAGGAACT
    TTGATCGCAGGTGCAGATGAACGCCGTCTCCATTCGAGTGACTGGGGTGATATCGGTATG
    GTCATCAGACGTAGTGAAGATAATGGAAAGACATGGGGAGATAAGGTGGTTATCTCCAAT
    CTTCGAGATAATCCTGAAGCTAAAGATCCTGCTGCGCCATCGCCTCTAAATATTGATATG
    GTTTTGGTTCAAGACCCGACAACAAAGAGAATCTTCTCAATTTATGATATGTTCCCAGAA
    GGTCGAGCAGTTTTTGGAATGCCAAAAACACCTGAAAAAGCTTATGAAAAGATAGGGGAT
    AAAACTTATCAAATCTTGTATAAACAAGGAGAGTCTGGTCATTATACTGTTCGTGAGAAT
    GGAGAAGTGTATAATGCACAAAATCAAAAGACGGATTATCGTGTTGTAGTGAATCCAACA
    GAACCTGGCTATAGAGATAAAGGAAATCTTTACAAAGGTCAGGAATTGATTGGAAATATC
    TATTTTGCACACAGTACAAAAAATCCATTTAGAGTAGCCAATACGAGCTATCTATGGATG
    TCATATAGTGACGATGATGGTAAAACTTGGTCTGCACCGAGAGACATTACTCCAGGTCTT
    CGCAAGGATTGGATGAAGTTCCTAGGAACAGGTCCTGGAACAGGAATTGTACTTCGGAAT
    GGGCCTCACAAGGGACGGATTTTGATACCGGTTTATACGACTAATAATGTATCTCACTTA
    AATGGCTCGCAATCTTCTCGTGTCATCTATTCAGATGATCATGGAAAAACTTGGCATGCT
    GGAGAAGCGGTCAACGATAACCGTCAGGTAGACGGTCAAAAGATCCACTCTTCTACGATG
    AACAATAAACGTGCGCAAAATACAGAATCAACGGTGGTACAACTAAACAATGGAGATGTT
    AAACTCTTTATGCGTGGTTTGACTGGAGATCTTCAGGTTGCTACAAGTAAAGACGGAGGA
    GTGACTTGGGAGAAGGATATCAAACGTTATCCACAGGTTAAAGATGTCTATGTTCAAATG
    TCTGCTATCCATACGATGCACGAAGGAAAAGAATACATCATCCTCAGTAATGCAGGTGGA
    CCGAAACGTGAAAATGGGATGGTCCACTTGGCACGTGTCGAAGAAAATGGTGAGTTGACT
    TGGCTCAAACACAATCCAATTCAAAAAGGAGAGTTTGCCTATAATTCGCTCCAAGAATTA
    GGAAATGGGGAGTATGGTATCTTGTATGAACATACTGAAAAAGGACAAAATGCCTATACC
    CTATCATTTAGAAAATTTAATTGGGACTTTTTGAGCAAAGATCTGATTTCTCCTACCGAA
    GCGAAAGTGAAGCGAACTAGAGAGATGGGCAAAGGAGAGATGGGCAAAGGAGTTATTGGC
    TTGGAGTTCGACTCAGAAGTATTGGTCAACAAGGCTCCAACCCTTCAATTGGCAAATGGT
    AAAACAGCGACTTTCCTAACCCAGTATGATAGCAAGACCTTGTTGTTTGCAGTAGATAAG
    GAAGATATCGGACAGAAAATTATTGGTATAGCTAAAGGAAGCATCGAAAGTATGCATAAT
    CTTCCTGTAAATCTAGCAGGTGCCAGAGTTCCTGGCGGAGTAAATGGTAGCAAAGCAGCG
    GTGCATGAAGTTCCAGAATTTACAAGGGGAGTTAATGGTACAGAGCCAGCTGTTCATGAA
    ATCGCAGAGTATAAGGGATCTGATTCGCTTGTAACTCTTACTACAAAAGAAGATTATACT
    TACAAAGCTCCTCTTGCTCAGCAGGCACTTCCTGAAACAGGAAACAAGGAGAGTGACCTC
    CTAGCTTCACTAGGACTAACAGCTTTCTTCCTTGGTCTGTTTACGCTAGGGAAAAAGAGA
    GAACAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2160
    2220
    2280
    2340
    2400
    2460
    2520
    2580
    2640
    2700
    2760
    2820
    2829

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: A66_01518 [new locus tag: A66_RS07545 ]
  • symbol: A66_01518
  • description: Sialidase
  • length: 942
  • theoretical pI: 7.9856
  • theoretical MW: 104678
  • GRAVY: -0.679299

⊟Function[edit | edit source]

  • reaction:
    EC 3.2.1.18?  ExPASy
    Exo-alpha-sialidase Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates
  • TIGRFAM:
    Cell structure Cell envelope Other LPXTG cell wall anchor domain (TIGR01167; HMM-score: 17.9)
    and 1 more
    type VII secretion effector, TIGR04197 family (TIGR04197; HMM-score: 12.9)
  • TheSEED: data available for D39, Hungary19A-6
  • PFAM:
    Concanavalin (CL0004) Sialidase; Sialidase, N-terminal domain (PF02973; HMM-score: 285.8)
    and 11 more
    Sialidase (CL0434) BNR_2; BNR repeat-like domain (PF13088; HMM-score: 78.5)
    Concanavalin (CL0004) Laminin_G_3; Concanavalin A-like lectin/glucanases superfamily (PF13385; HMM-score: 52.4)
    Sialidase (CL0434) BNR_3; BNR repeat-like domain (PF13859; HMM-score: 44.1)
    BNR; BNR/Asp-box repeat (PF02012; HMM-score: 35.7)
    no clan defined Gram_pos_anchor; LPXTG cell wall anchor motif (PF00746; HMM-score: 18.9)
    Beta_propeller (CL0186) CyRPA; Cysteine-Rich Protective Antigen 6 bladed domain (PF18638; HMM-score: 13.5)
    Sialidase (CL0434) Sortilin-Vps10; Sortilin, neurotensin receptor 3, (PF15902; HMM-score: 13)
    E-set (CL0159) CHB_HEX_C; Chitobiase/beta-hexosaminidase C-terminal domain (PF03174; HMM-score: 12.9)
    no clan defined Epiglycanin_TR; Tandem-repeating region of mucin, epiglycanin-like (PF05647; HMM-score: 12.4)
    HAD (CL0137) PGP_phosphatase; Mitochondrial PGP phosphatase (PF09419; HMM-score: 12.1)
    GT-C (CL0111) YfhO; Bacterial membrane protein YfhO (PF09586; HMM-score: 5.5)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cellwall
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 10
    • Extracellular Score: 0
    • Internal Helices: 0
  • DeepLocPro: Cell wall & surface
    • Cytoplasmic Score: 0.0002
    • Cytoplasmic Membrane Score: 0.045
    • Cell wall & surface Score: 0.7669
    • Extracellular Score: 0.1879
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.310399
    • TAT(Tat/SPI): 0.012694
    • LIPO(Sec/SPII): 0.021022
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: CRI62229 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MIVGAVVFGTSPVLAQEGASEQPLANETQLSGGSSTLTDTEKSQPSSETELSGNKQEQERKDKQEEKIPRDYYARDLENVETVIEKEDVETNASNGQRVDLSSELDKLKKLENATVHMEFKPDAKAPAFYNLFSVSSATKKDEYFTMAVYNNTATLEGRGSDGKQFYNNYNDAPLKVKPGQWNSVTFTVEKPTAELPKGRVRLYVNGVLSRTSLRSGNFIKDMPDVTHVQIGATKRANNTVWGSNLQIRNLTVYNRALTPEEVQKRSQLFKRSDLEKKLPEGAALTEKTDIFESGRNGNPNKDGIKSYRIPALLKTDKGTLIAGADERRLHSSDWGDIGMVIRRSEDNGKTWGDKVVISNLRDNPEAKDPAAPSPLNIDMVLVQDPTTKRIFSIYDMFPEGRAVFGMPKTPEKAYEKIGDKTYQILYKQGESGHYTVRENGEVYNAQNQKTDYRVVVNPTEPGYRDKGNLYKGQELIGNIYFAHSTKNPFRVANTSYLWMSYSDDDGKTWSAPRDITPGLRKDWMKFLGTGPGTGIVLRNGPHKGRILIPVYTTNNVSHLNGSQSSRVIYSDDHGKTWHAGEAVNDNRQVDGQKIHSSTMNNKRAQNTESTVVQLNNGDVKLFMRGLTGDLQVATSKDGGVTWEKDIKRYPQVKDVYVQMSAIHTMHEGKEYIILSNAGGPKRENGMVHLARVEENGELTWLKHNPIQKGEFAYNSLQELGNGEYGILYEHTEKGQNAYTLSFRKFNWDFLSKDLISPTEAKVKRTREMGKGEMGKGVIGLEFDSEVLVNKAPTLQLANGKTATFLTQYDSKTLLFAVDKEDIGQKIIGIAKGSIESMHNLPVNLAGARVPGGVNGSKAAVHEVPEFTRGVNGTEPAVHEIAEYKGSDSLVTLTTKEDYTYKAPLAQQALPETGNKESDLLASLGLTAFFLGLFTLGKKREQ

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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