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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 13-DEC-2020

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae A66
  • locus tag: A66_RS05370 [old locus tag: A66_01072 ]
  • pan locus tag?: PNEUPAN002451000
  • symbol: A66_RS05370
  • pan gene symbol?: lacE-2
  • synonym:
  • product: lactose-specific PTS transporter subunit EIIC

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: A66_RS05370 [old locus tag: A66_01072 ]
  • symbol: A66_RS05370
  • product: lactose-specific PTS transporter subunit EIIC
  • replicon: chromosome
  • strand: -
  • coordinates: 1040054..1041745
  • length: 1692
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_LN847353 (1040054..1041745) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1047 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    ATGAACAAACTAATTGCATTTATCGAGAAAGGAAAGCCTTTCTTTGAGAAACTATCTCGT
    AATATCTATCTTCGTGCTATTCGTGATGGTTTCATTGCAGGTATGCCTGTTATTCTCTTC
    TCAAGTATCTTTATCTTGATTGCCTTTGTACCAAACTCATGGGGCTTTAAATGGTCTGAT
    GAAGTTGTAGCCTTTCTGATGAAACCTTATAGCTATTCTATGGGTATTCTGGCTCTCTTG
    GTAGCTGGTACAACAGCTAAGTCATTGACTGACTCAGTAAACCGGAGCATGGAGAAAACC
    AATCAAATCAACTATATGTCAACGCTGTTAGCAGCGATTGTTGGTTTGTTGATGTTGGCA
    GCTGATCCTATCGAAAGTGGTCTAGCTACTGGATTCTTGGGGACAAAAGGTTTGCTTTCA
    GCCTTCCTTGCTGCCTTTGTTACTGTAGCCATCTATAAGGTTTGTGTTAAGAACAACGTC
    ACTATTCGTATGCCTGACGAAGTTCCACCAAATATCTCACAAGTCTTTAAAGATGTGATT
    CCATTCACTCTATCTGTTGTTTCTCTTTATGCTCTTGACTTATTAGCACGTTATTTTGTT
    GGTTCTAGTGTGGCAGAATCAATCGGTAAATTCTTTGCACCACTCTTCTCAGCAGCAGAC
    GGATACCTTGGTATTACGATTATCTTTGGTGCCTTTGCCTTCTTCTGGTTTGTGGGTATT
    CATGGTCCATCTATTGTTGAACCTGCTATCGCAGCAATTACCTATGCAAATGCTGAAGTC
    AACTTGAACCTTCTCCAACAAGGTATGCACGCTGACAAGATTCTTACTTCTGGTACACAA
    ATGTTTATCGTTACCATGGGTGGTACTGGTGCGACACTGGTTGTTCCATTCATGTTCATG
    TGGTTAACAAAATCAAAACGTAACCGTGCAATCGGACGTGCTTCAGTAGTTCCTACCTTC
    TTCGGTGTAAATGAGCCAATCTTGTTTGGTGCACCTCTTGTTTTGAATCCAATCTTCTTC
    ATTCCATTTATCTTTGCTCCAATTGCAAACGTATGGATTTTCAAATTCTTTATTGAAACT
    CTTGGAATGAACTCATTCACTGCTAATCTACCATGGACAACTCCAGCTCCACTAGGTCTA
    GTTCTTGGAACTAACTTCCAAGTGCTATCATTCATTCTTGCTGCCCTTCTAATCGTGGTT
    GACGTAGTCATTTACTATCCATTCCTTAAAGTTTATGACGAACAAATTCTTGAAGAAGAA
    CGTTCAGGTAAGTCTAATGATGAATTGAAAGAAAAAGTTGCTGCAAACTTCAACACTGCA
    AAAGCGGATGCTATTCTTGAAAAAGCGGGTGTCGATGCAGCACAAAATACCATCACTGAA
    GAAACAAATGTCCTCGTTCTCTGTGCTGGTGGAGGTACAAGTGGACTCCTTGCAAATGCT
    TTGAATAAGGCAGCAGCAGAATACAATGTCCCTGTGAAAGCAGCAGCAGGCGGCTATGGT
    GCTCACCGTGAAATGTTACCAGAGTTTGATTTGGTTATCCTTGCTCCTCAAGTTGCTTCA
    AACTTTGAAGATATGAAGGCAGAAACAGATAAGCTCGGTATTAAACTTGCTAAGACAGAA
    GGCGCTCAATACATCAAATTAACTCGTGATGGAAAAGGTGCCCTAGCATTCGTACAAGAG
    CAATTCGATTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1692

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: A66_RS05370 [old locus tag: A66_01072 ]
  • symbol: A66_RS05370
  • description: lactose-specific PTS transporter subunit EIIC
  • length: 563
  • theoretical pI: 5.90143
  • theoretical MW: 61077.1
  • GRAVY: 0.511545

⊟Function[edit | edit source]

  • reaction:
    EC 2.7.1.207?  ExPASy
    Protein-N(pi)-phosphohistidine--lactose phosphotransferase [Protein]-N(pi)-phospho-L-histidine + lactose(Side 1) = [protein]-L-histidine + lactose 6'-phosphate(Side 2)
  • TIGRFAM:
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids PTS system, lactose-specific IIC component (TIGR00394; EC 2.7.1.69; HMM-score: 733.9)
    Signal transduction Signal transduction PTS PTS system, lactose-specific IIC component (TIGR00394; EC 2.7.1.69; HMM-score: 733.9)
    and 10 more
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids PTS system, cellobiose-specific IIC component (TIGR00359; EC 2.7.1.69; HMM-score: 251.4)
    Signal transduction Signal transduction PTS PTS system, cellobiose-specific IIC component (TIGR00359; EC 2.7.1.69; HMM-score: 251.4)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids PTS system, lactose/cellobiose family IIC component (TIGR00410; EC 2.7.1.69; HMM-score: 251.4)
    Signal transduction Signal transduction PTS PTS system, lactose/cellobiose family IIC component (TIGR00410; EC 2.7.1.69; HMM-score: 251.4)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids PTS system, lactose/cellobiose family IIB component (TIGR00853; HMM-score: 197.8)
    Signal transduction Signal transduction PTS PTS system, lactose/cellobiose family IIB component (TIGR00853; HMM-score: 197.8)
    PTS system, beta-glucoside-specific IIABC component (TIGR01995; EC 2.7.1.69; HMM-score: 22.8)
    PTS system, sucrose-specific IIBC component (TIGR01996; EC 2.7.1.69; HMM-score: 19.6)
    Genetic information processing Mobile and extrachromosomal element functions Prophage functions holin, phage phi LC3 family (TIGR01598; HMM-score: 13)
    Genetic information processing Protein synthesis tRNA and rRNA base modification tRNA 2-selenouridine synthase (TIGR03167; EC 2.9.1.-; HMM-score: 12.6)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    PTS_EIIC (CL0493) PTS_EIIC; Phosphotransferase system, EIIC (PF02378; HMM-score: 224.2)
    and 2 more
    Phosphatase (CL0031) PTS_IIB; PTS system, Lactose/Cellobiose specific IIB subunit (PF02302; HMM-score: 38.8)
    no clan defined NBD_C; Nucleotide-binding C-terminal domain (PF17042; HMM-score: 15.1)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 9
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.008724
    • TAT(Tat/SPI): 0.000175
    • LIPO(Sec/SPII): 0.001198
  • predicted transmembrane helices (TMHMM): 8

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_053039619 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MNKLIAFIEKGKPFFEKLSRNIYLRAIRDGFIAGMPVILFSSIFILIAFVPNSWGFKWSDEVVAFLMKPYSYSMGILALLVAGTTAKSLTDSVNRSMEKTNQINYMSTLLAAIVGLLMLAADPIESGLATGFLGTKGLLSAFLAAFVTVAIYKVCVKNNVTIRMPDEVPPNISQVFKDVIPFTLSVVSLYALDLLARYFVGSSVAESIGKFFAPLFSAADGYLGITIIFGAFAFFWFVGIHGPSIVEPAIAAITYANAEVNLNLLQQGMHADKILTSGTQMFIVTMGGTGATLVVPFMFMWLTKSKRNRAIGRASVVPTFFGVNEPILFGAPLVLNPIFFIPFIFAPIANVWIFKFFIETLGMNSFTANLPWTTPAPLGLVLGTNFQVLSFILAALLIVVDVVIYYPFLKVYDEQILEEERSGKSNDELKEKVAANFNTAKADAILEKAGVDAAQNTITEETNVLVLCAGGGTSGLLANALNKAAAEYNVPVKAAAGGYGAHREMLPEFDLVILAPQVASNFEDMKAETDKLGIKLAKTEGAQYIKLTRDGKGALAFVQEQFD

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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