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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TIGR4
  • locus tag: SP_1185 [new locus tag: SP_RS05830 ]
  • pan locus tag?: PNEUPAN002451000
  • symbol: lacE-2
  • pan gene symbol?: lacE-2
  • synonym:
  • product: PTS system, lactose-specific IIBC components

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP_1185 [new locus tag: SP_RS05830 ]
  • symbol: lacE-2
  • product: PTS system, lactose-specific IIBC components
  • replicon: chromosome
  • strand: -
  • coordinates: 1122784..1124475
  • length: 1692
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    ATGAATAAACTAATTGCATTTATCGAGAAAGGAAAGCCTTTCTTTGAAAAACTATCTCGT
    AATATCTATCTTCGTGCTATTCGTGATGGTTTCATTGCAGGTATGCCTGTTATTCTCTTC
    TCAAGTATCTTTATCTTGATTGCCTTTGTACCAAACTCATGGGGCTTTAAATGGTCTGAT
    GAAGTTGTAGCCTTTCTGATGAAACCTTATAGCTATTCTATGGGTATTCTGGCTCTCTTG
    GTAGCTGGTACAACAGCTAAGTCATTGACTGACTCAGTAAACCGGAGCATGGAAAAAACC
    AATCAAATCAAGTATATGTCAACATTGTTGGCAGCAATTGTTGGTTTGTTGATGTTGGCA
    GCTGATCCTATCGAAAGTGGTCTAGCTACTGGATTCTTGGGGACAAAAGGTTTGCTTTCA
    GCCTTCCTTGCTGCCTTTGTTACTGTAGCCATCTATAAGGTTTGTGTTAAGAACAACGTC
    ACTATTCGTATGCCTGACGAAGTTCCACCAAATATCTCACAAGTCTTTAAAGATGTGATT
    CCATTCACTCTATCTGTTGTTTCTCTTTATGCTCTTGACTTATTAGCACGTTATTTTGTT
    GGTTCTAGTGTGGCAGAATCAATCGGTAAATTCTTCGCACCACTCTTCTCAGCAGCAGAC
    GGATACCTTGGTATTACCATTATCTTTGGTGCCTTTGCCTTCTTCTGGTTTGTTGGGATT
    CATGGTCCATCTATCGTTGAACCAGCTATCGCAGCTATTACCTATGCCAATGCCGAAGTT
    AACTTGAACCTTCTCCAACAAGGGATGCATGCAGACAAGATTCTTACTTCTGGTACACAA
    ATGTTTATCGTTACCATGGGTGGTACAGGTGCGACATTGGTCGTTCCATTTATGTTCATG
    TGGTTGACAAAATCGAAACGTAACCGTGCAATCGGACGTGCTTCAGTAGTTCCTACCTTC
    TTCGGTGTAAATGAACCAATCTTGTTTGGTGCACCTCTTGTTTTGAATCCAATCTTCTTC
    ATTCCATTTATCTTTGCTCCAATTGCAAACGTATGGATTTTCAAATTCTTTATTGAAACT
    CTTGGAATGAACTCATTCACTGCTAATCTACCATGGACAACTCCAGCTCCACTAGGTCTA
    GTTCTTGGAACTAACTTCCAAGTGCTATCATTCATTCTTGCTGCCCTTCTAATCGTGGTT
    GACGTTGTCATTTACTATCCATTCCTTAAGGTCTATGATGAACAAATTCTTGAAGAAGAA
    CGTTCAGGTAAGTCTAATGATGAATTGAAAGAAAAAGTTGCTGCAAACTTCAACACTGCA
    AAAGCGGATGCTATTCTTGAAAAAGCGGGTGTCGATGCAGCACAAAATACCATCACTGAA
    GAAACAAATGTCCTCGTTCTCTGTGCAGGTGGAGGAACAAGTGGTCTCCTTGCAAATGCT
    TTGAATAAGGCAGCAGCAGAATACAATGTCCCTGTGAAAGCAGCAGCAGGCGGCTATGGT
    GCTCACCGTGAAATGTTACCAGAGTTTGATCTTGTTATCCTTGCCCCTCAAGTTGCTTCA
    AACTTTGAAGATATGAAAGCAGAAACAGATAAGCTCGGTATTAAACTAGCGAAAACAGAA
    GGCGCTCAATACATCAAATTAACTCGTGATGGAAAAGGTGCTCTTGCATTCGTACAAGCG
    CAATTCGATTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1692

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP_1185 [new locus tag: SP_RS05830 ]
  • symbol: LacE-2
  • description: PTS system, lactose-specific IIBC components
  • length: 563
  • theoretical pI: 6.80667
  • theoretical MW: 61033.1
  • GRAVY: 0.520249

⊟Function[edit | edit source]

  • reaction:
    EC 2.7.1.69?  ExPASy
    Transferred entry: 2.7.1.191, 2.7.1.192, 2.7.1.193, 2.7.1.194, 2.7.1.195, 2.7.1.196, 2.7.1.197, 2.7.1.198, 2.7.1.199, 2.7.1.200, 2.7.1.201, 2.7.1.202, 2.7.1.203, 2.7.1.204, 2.7.1.205, 2.7.1.206, 2.7.1.207 and 2.7.1.208
  • TIGRFAM:
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids PTS system, lactose-specific IIC component (TIGR00394; EC 2.7.1.69; HMM-score: 731.1)
    Signal transduction Signal transduction PTS PTS system, lactose-specific IIC component (TIGR00394; EC 2.7.1.69; HMM-score: 731.1)
    and 10 more
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids PTS system, cellobiose-specific IIC component (TIGR00359; EC 2.7.1.69; HMM-score: 251.1)
    Signal transduction Signal transduction PTS PTS system, cellobiose-specific IIC component (TIGR00359; EC 2.7.1.69; HMM-score: 251.1)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids PTS system, lactose/cellobiose family IIC component (TIGR00410; EC 2.7.1.69; HMM-score: 251.1)
    Signal transduction Signal transduction PTS PTS system, lactose/cellobiose family IIC component (TIGR00410; EC 2.7.1.69; HMM-score: 251.1)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids PTS system, lactose/cellobiose family IIB component (TIGR00853; HMM-score: 197.8)
    Signal transduction Signal transduction PTS PTS system, lactose/cellobiose family IIB component (TIGR00853; HMM-score: 197.8)
    PTS system, beta-glucoside-specific IIABC component (TIGR01995; EC 2.7.1.69; HMM-score: 20.8)
    PTS system, sucrose-specific IIBC component (TIGR01996; EC 2.7.1.69; HMM-score: 19.5)
    Genetic information processing Mobile and extrachromosomal element functions Prophage functions holin, phage phi LC3 family (TIGR01598; HMM-score: 12.6)
    Genetic information processing Protein synthesis tRNA and rRNA base modification tRNA 2-selenouridine synthase (TIGR03167; EC 2.9.1.-; HMM-score: 12.6)
  • TheSEED  :
    • PTS system, lactose-specific IIB component (EC 2.7.1.69)
    • PTS system, lactose-specific IIC component (EC 2.7.1.69)
    Carbohydrates Di- and oligosaccharides Lactose and Galactose Uptake and Utilization  PTS system, lactose-specific IIB component (EC 2.7.1.69)
    and 1 more
    Carbohydrates Di- and oligosaccharides Lactose and Galactose Uptake and Utilization  PTS system, lactose-specific IIC component (EC 2.7.1.69)
  • PFAM:
    PTS_EIIC (CL0493) PTS_EIIC; Phosphotransferase system, EIIC (PF02378; HMM-score: 222.1)
    and 2 more
    Phosphatase (CL0031) PTS_IIB; PTS system, Lactose/Cellobiose specific IIB subunit (PF02302; HMM-score: 38.8)
    no clan defined NBD_C; Nucleotide-binding C-terminal domain (PF17042; HMM-score: 15.1)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 9
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.008724
    • TAT(Tat/SPI): 0.000175
    • LIPO(Sec/SPII): 0.001198
  • predicted transmembrane helices (TMHMM): 8

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MNKLIAFIEKGKPFFEKLSRNIYLRAIRDGFIAGMPVILFSSIFILIAFVPNSWGFKWSDEVVAFLMKPYSYSMGILALLVAGTTAKSLTDSVNRSMEKTNQIKYMSTLLAAIVGLLMLAADPIESGLATGFLGTKGLLSAFLAAFVTVAIYKVCVKNNVTIRMPDEVPPNISQVFKDVIPFTLSVVSLYALDLLARYFVGSSVAESIGKFFAPLFSAADGYLGITIIFGAFAFFWFVGIHGPSIVEPAIAAITYANAEVNLNLLQQGMHADKILTSGTQMFIVTMGGTGATLVVPFMFMWLTKSKRNRAIGRASVVPTFFGVNEPILFGAPLVLNPIFFIPFIFAPIANVWIFKFFIETLGMNSFTANLPWTTPAPLGLVLGTNFQVLSFILAALLIVVDVVIYYPFLKVYDEQILEEERSGKSNDELKEKVAANFNTAKADAILEKAGVDAAQNTITEETNVLVLCAGGGTSGLLANALNKAAAEYNVPVKAAAGGYGAHREMLPEFDLVILAPQVASNFEDMKAETDKLGIKLAKTEGAQYIKLTRDGKGALAFVQAQFD

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator: CcpA regulon
    CcpA(TF)important in Global catabolite repression; RegPrecise 

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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