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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 17-DEC-2024

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae A66
  • locus tag: A66_RS05860 [old locus tag: A66_01176 ]
  • pan locus tag?: PNEUPAN002567000
  • symbol: ffh
  • pan gene symbol?: ffh
  • synonym:
  • product: signal recognition particle protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: A66_RS05860 [old locus tag: A66_01176 ]
  • symbol: ffh
  • product: signal recognition particle protein
  • replicon: chromosome
  • strand: -
  • coordinates: 1145791..1147362
  • length: 1572
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Location: NZ_LN847353 (1145791..1147362) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1142 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    ATGGCATTTGAAAGTTTAACAGAACGTTTGCAGAACGTCTTTAAAAATCTACGTAAAAAA
    GGAAAAATCTCTGAATCTGATGTCCAAGAGGCAACCAAAGAAATTCGCTTGGCCTTGCTC
    GAGGCCGACGTTGCCTTGCCTGTTGTAAAGGACTTTATCAAGAAAGTTCGTGAGCGTGCA
    GTCGGGCATGAGGTCATTGATACACTTAATCCTGCGCAACAGATTATTAAAATCGTTGAT
    GAGGAACTGACAGCCGTTTTAGGTTCTGATACGGCAGAAATTATCAAGTCACCTAAGATT
    CCAACCATCATCATGATGGTTGGTTTACAAGGGGCTGGTAAAACAACCTTTGCTGGTAAA
    TTGGCCAACAAACTCAAGAAAGAAGAAAATGCTCGTCCTTTGATGATTGCGGCGGATATT
    TATCGTCCAGCTGCCATTGACCAGCTTAAGACCTTGGGACAACAGATTGATGTGCCTGTC
    TTTGCACTTGGAACAGAAGTACCAGCTGTTGAGATTGTACGTCAAGGTTTGGAGCAAGCC
    CAAACTAATCATAACGACTATGTCTTGATTGATACTGCGGGTCGTTTGCAGATTGATGAG
    CTCCTCATGAATGAGCTTCGTGATGTGAAAGCATTGGCTCAACCAAATGAAATCTTGCTT
    GTCGTTGATGCTATGATTGGTCAGGAAGCAGCCAATGTTGCGCGTGAGTTTAATGCTCAG
    TTGGAAGTGACTGGGGTCATCCTTACCAAGATTGATGGCGATACTCGTGGTGGTGCGGCT
    CTATCGGTTCGTCACATCACTGGAAAACCAATCAAGTTCACTGGTACAGGTGAAAAAATT
    ACAGATATCGAAACCTTCCACCCAGACCGTATGTCTAGCCGTATCCTTGGCATGGGGGAT
    ATGCTCACTTTGATTGAGAAAGCTTCTCAGGAATACGATGAACAAAAAGCCCTTGAAATG
    GCTGAGAAGATGCGCGAAAACACCTTTGATTTTAATGATTTCATCGATCAATTGGATCAG
    GTGCAAAATATGGGGCCGATGGAAGACTTGCTCAAGATGATTCCAGGTATGGCCAACAAT
    CCAGCACTTCAAAACATGAAGGTGGATGAACGCCAGATTGCTCGTAAACGTGCCATTGTG
    TCTTCGATGACACCTGAAGAACGTGAAAACCCAGATTTGTTAAATCCAAGCCGTCGCCGT
    CGTATTGCTGCTGGTTCTGGAAATACATTCGTCGAAGTCAATAAATTCATCAAGGACTTT
    AACCAGGCTAAACAGCTCATGCAGGGTGTTATGTCTGGGGATATGAATAAAATGATGAAG
    CAAATGGGGATTAATCCAAATAACCTTCCTAAAAATATGCCAAATATGGGAGGAATGGAT
    ATGTCTGCCCTTGAACGAATGATGGGACAAGGCGGTATGCCTGACTTATCAGCTCTCGGA
    GGAGCAGGAATGCCAGATATGAGCCAGATGTTTGGTGGCGGTTTGAAAGGTAAAATTGGT
    GAATTTGCCATGAAACAGTCCATGAAACGTATGGCTAACAAAATGAAGAAAGCGAAGAAG
    AAACGCAAGTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1572

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: A66_RS05860 [old locus tag: A66_01176 ]
  • symbol: Ffh
  • description: signal recognition particle protein
  • length: 523
  • theoretical pI: 9.12807
  • theoretical MW: 57856
  • GRAVY: -0.350096

⊟Function[edit | edit source]

  • TIGRFAM:
    Genetic information processing Protein fate Protein and peptide secretion and trafficking signal recognition particle protein (TIGR00959; HMM-score: 638.7)
    and 9 more
    signal recognition particle protein SRP54 (TIGR01425; HMM-score: 292.4)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking signal recognition particle-docking protein FtsY (TIGR00064; HMM-score: 219.6)
    Cellular processes Cellular processes Chemotaxis and motility flagellar biosynthesis protein FlhF (TIGR03499; HMM-score: 66.9)
    Genetic information processing Protein synthesis tRNA aminoacylation L-seryl-tRNA(Sec) kinase (TIGR03574; EC 2.7.1.164; HMM-score: 18)
    exopolysaccharide/PEP-CTERM locus tyrosine autokinase (TIGR03018; EC 2.7.10.2; HMM-score: 16.5)
    Genetic information processing Protein synthesis tRNA and rRNA base modification tRNA threonylcarbamoyl adenosine modification protein YjeE (TIGR00150; HMM-score: 14.1)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA polymerase III, subunit gamma and tau (TIGR02397; EC 2.7.7.7; HMM-score: 14)
    Metabolism Central intermediary metabolism Sulfur metabolism adenylyl-sulfate kinase (TIGR00455; EC 2.7.1.25; HMM-score: 12.8)
    Unknown function General small GTP-binding protein domain (TIGR00231; HMM-score: 12.6)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    P-loop_NTPase (CL0023) SRP54; SRP54-type protein, GTPase domain (PF00448; HMM-score: 253)
    and 29 more
    HTH (CL0123) SRP_SPB; Signal peptide binding domain (PF02978; HMM-score: 109.7)
    no clan defined SRP54_N; SRP54-type protein, helical bundle domain (PF02881; HMM-score: 81)
    P-loop_NTPase (CL0023) CbiA; CobQ/CobB/MinD/ParA nucleotide binding domain (PF01656; HMM-score: 26)
    Zeta_toxin; Zeta toxin (PF06414; HMM-score: 25)
    AAA_33; AAA domain (PF13671; HMM-score: 24.7)
    AAA_22; AAA domain (PF13401; HMM-score: 23.4)
    cobW; CobW/HypB/UreG, nucleotide-binding domain (PF02492; HMM-score: 23.2)
    DO-GTPase1; Double-GTPase 1 (PF19975; HMM-score: 18.9)
    MMR_HSR1; 50S ribosome-binding GTPase (PF01926; HMM-score: 18.8)
    TsaE; Threonylcarbamoyl adenosine biosynthesis protein TsaE (PF02367; HMM-score: 15.9)
    APS_kinase; Adenylylsulphate kinase (PF01583; HMM-score: 15.6)
    NACHT; NACHT domain (PF05729; HMM-score: 15.3)
    ATP_bind_1; Conserved hypothetical ATP binding protein (PF03029; HMM-score: 15.1)
    6PF2K; 6-phosphofructo-2-kinase (PF01591; HMM-score: 14.3)
    PduV-EutP; Ethanolamine utilisation - propanediol utilisation (PF10662; HMM-score: 14.3)
    AAA_18; AAA domain (PF13238; HMM-score: 14.3)
    AAA_16; AAA ATPase domain (PF13191; HMM-score: 13.6)
    AAA_31; AAA domain (PF13614; HMM-score: 13.3)
    RGS (CL0272) RGS-like; Regulator of G protein signalling-like domain (PF09128; HMM-score: 13.2)
    P-loop_NTPase (CL0023) SRPRB; Signal recognition particle receptor beta subunit (PF09439; HMM-score: 13.1)
    MobB; Molybdopterin guanine dinucleotide synthesis protein B (PF03205; HMM-score: 12.8)
    AAA_28; AAA domain (PF13521; HMM-score: 12.7)
    RNA_helicase; RNA helicase (PF00910; HMM-score: 12.4)
    AAA_17; AAA domain (PF13207; HMM-score: 12.2)
    CLP1_P; mRNA cleavage and polyadenylation factor CLP1 P-loop (PF16575; HMM-score: 12.2)
    Hy-ly_N (CL0372) Lyase_catalyt; Lyase, catalytic (PF09093; HMM-score: 12.1)
    P-loop_NTPase (CL0023) AAA_14; AAA domain (PF13173; HMM-score: 11.6)
    AAA_25; AAA domain (PF13481; HMM-score: 11.4)
    AAA; ATPase family associated with various cellular activities (AAA) (PF00004; HMM-score: 10.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 1.05
    • Cytoplasmic Membrane Score: 8.78
    • Cellwall Score: 0.08
    • Extracellular Score: 0.09
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.8528
    • Cytoplasmic Membrane Score: 0.0695
    • Cell wall & surface Score: 0.0001
    • Extracellular Score: 0.0776
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.001335
    • TAT(Tat/SPI): 0.000163
    • LIPO(Sec/SPII): 0.000179
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000863630 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MAFESLTERLQNVFKNLRKKGKISESDVQEATKEIRLALLEADVALPVVKDFIKKVRERAVGHEVIDTLNPAQQIIKIVDEELTAVLGSDTAEIIKSPKIPTIIMMVGLQGAGKTTFAGKLANKLKKEENARPLMIAADIYRPAAIDQLKTLGQQIDVPVFALGTEVPAVEIVRQGLEQAQTNHNDYVLIDTAGRLQIDELLMNELRDVKALAQPNEILLVVDAMIGQEAANVAREFNAQLEVTGVILTKIDGDTRGGAALSVRHITGKPIKFTGTGEKITDIETFHPDRMSSRILGMGDMLTLIEKASQEYDEQKALEMAEKMRENTFDFNDFIDQLDQVQNMGPMEDLLKMIPGMANNPALQNMKVDERQIARKRAIVSSMTPEERENPDLLNPSRRRRIAAGSGNTFVEVNKFIKDFNQAKQLMQGVMSGDMNKMMKQMGINPNNLPKNMPNMGGMDMSALERMMGQGGMPDLSALGGAGMPDMSQMFGGGLKGKIGEFAMKQSMKRMANKMKKAKKKRK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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