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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 17-DEC-2024

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae A66
  • locus tag: A66_RS08205 [old locus tag: A66_01649 ]
  • pan locus tag?: PNEUPAN003364000
  • symbol: A66_RS08205
  • pan gene symbol?: xpt
  • synonym:
  • product: xanthine phosphoribosyltransferase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: A66_RS08205 [old locus tag: A66_01649 ]
  • symbol: A66_RS08205
  • product: xanthine phosphoribosyltransferase
  • replicon: chromosome
  • strand: +
  • coordinates: 1577417..1577998
  • length: 582
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_LN847353 (1577417..1577998) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1628 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    ATGAAATTATTAGAAGAGCGCATCCTCAAGGATGGGCATATCTTGGGCGATAACATCCTC
    AAGGTAGATTCCTTTTTAACCCACCAAGTTGACTTTAGCTTGATGCGAGAGATTGGTAAG
    GTTTTTGCGGAAAAATTTGCTACTACTGGCATTACCAAGGTCGTAACCATTGAAGCGTCG
    GGTATTGCCCCAGCCGTTTTTACAGCTGAAGCCTTAAACGTTCCCATGATTTTCGCCAAA
    AAAGCTAAGAACATCACCATGAACGAAGGCATCTTAACTGCTCAAGTCTACTCCTTTACC
    AAGCAGGTGACCAGCACCGTTTCTATCGCTGGAAAATTCCTCTCACCAGAGGACAAGGTT
    TTGATTATCGACGATTTCCTTGCTAATGGCCAAGCTGCTAAAGGCTTGATTCAAATCATC
    GAACAGGCCGGTGCCACAGTCCAAGCTATCGGTATCGTGATTGAGAAATCCTTCCAAGAT
    GGTCGTGATTTGCTTGAAAAAGCAGGCTACCCTGTCCTATCACTTGCTCGCTTGGATCGT
    TTTGAAAATGGTCAGGTCGTATTTAAGGAGGCAGATCTCTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    582

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: A66_RS08205 [old locus tag: A66_01649 ]
  • symbol: A66_RS08205
  • description: xanthine phosphoribosyltransferase
  • length: 193
  • theoretical pI: 5.33287
  • theoretical MW: 21015.3
  • GRAVY: 0.228497

⊟Function[edit | edit source]

  • reaction:
    EC 2.4.2.22?  ExPASy
    Xanthine phosphoribosyltransferase XMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine
  • TIGRFAM:
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Salvage of nucleosides and nucleotides xanthine phosphoribosyltransferase (TIGR01744; EC 2.4.2.22; HMM-score: 268.1)
    and 6 more
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Purine ribonucleotide biosynthesis pur operon repressor PurR (TIGR01743; HMM-score: 72.2)
    Signal transduction Regulatory functions DNA interactions pur operon repressor PurR (TIGR01743; HMM-score: 72.2)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Salvage of nucleosides and nucleotides adenine phosphoribosyltransferase (TIGR01090; EC 2.4.2.7; HMM-score: 48.3)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Pyrimidine ribonucleotide biosynthesis orotate phosphoribosyltransferase (TIGR01367; EC 2.4.2.10; HMM-score: 39.1)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Pyrimidine ribonucleotide biosynthesis orotate phosphoribosyltransferase (TIGR00336; EC 2.4.2.10; HMM-score: 31.2)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Salvage of nucleosides and nucleotides hypoxanthine phosphoribosyltransferase (TIGR01203; EC 2.4.2.8; HMM-score: 14.2)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    PRTase-like (CL0533) Pribosyltran; Phosphoribosyl transferase domain (PF00156; HMM-score: 29.9)
    and 1 more
    UPRTase; Uracil phosphoribosyltransferase (PF14681; HMM-score: 14.1)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9884
    • Cytoplasmic Membrane Score: 0.0038
    • Cell wall & surface Score: 0.0006
    • Extracellular Score: 0.0073
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.002919
    • TAT(Tat/SPI): 0.001133
    • LIPO(Sec/SPII): 0.000203
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000770421 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKLLEERILKDGHILGDNILKVDSFLTHQVDFSLMREIGKVFAEKFATTGITKVVTIEASGIAPAVFTAEALNVPMIFAKKAKNITMNEGILTAQVYSFTKQVTSTVSIAGKFLSPEDKVLIIDDFLANGQAAKGLIQIIEQAGATVQAIGIVIEKSFQDGRDLLEKAGYPVLSLARLDRFENGQVVFKEADL

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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