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serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
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G54
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HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 13-OCT-2024

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae NCTC7465
  • locus tag: AT689_RS01525 [old locus tag: ERS445053_00309 ]
  • pan locus tag?: PNEUPAN000900000
  • symbol: ribE
  • pan gene symbol?: ribE
  • synonym:
  • product: riboflavin synthase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: AT689_RS01525 [old locus tag: ERS445053_00309 ]
  • symbol: ribE
  • product: riboflavin synthase
  • replicon: chromosome
  • strand: +
  • coordinates: 297880..298515
  • length: 636
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_LN831051 (297880..298515) NCBI
  • BioCyc: AT689_RS01525 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0168 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    ATGTTCACAGGAATAATTGAAGAAATCGGAAAAGTTGAAAGAATACAGAAAGACTCTCGT
    AATTGTAAACTATCAATTAAAGCCTCAAAAATATTAACGGATATCCATTTAGGCGATAGT
    ATAGCAGTAAATGGTATCTGTCTTACAGTTACTCATTTCAATCATCAATCCTTTACAGTT
    GATGTAATGAATGAAACATGGAGTCGAACAGCTCTTACTCTATTAAAACATGGAAGTGAG
    GTGAATCTAGAAAGAGCCTTATCTGTCAACGGTCGACTTGGGGGTCACGTCGTTACAGGA
    CACATTGATGGTACAGGAAAAATCTCGTCAATAAAAAAAGATGATAATGCTGTATGGTAT
    CAAATCAACACACAAAAAGAAATTTTAGATTTAATAGTTGAAAAAGGATCTATTACAATT
    GACGGCATTAGTCTGACTGTCGCTAAAGTCTCCAAAGTAAACTTTTCAGTATCTGTTATC
    CCTCATACCTTGGAACAAACCATTCTTAAGAGTAAACAAGTCGGGAGTACAGTAAATCTT
    GAAAATGATATCTTAGGTAAATATGTGCAAAAACTGATGGATAACTCTCCAAAATCAGAA
    ATATCTAAGGAACTATTATATCAAAATGGATTTTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    636

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: AT689_RS01525 [old locus tag: ERS445053_00309 ]
  • symbol: RibE
  • description: riboflavin synthase
  • length: 211
  • theoretical pI: 8.24977
  • theoretical MW: 23244.5
  • GRAVY: -0.119431

⊟Function[edit | edit source]

  • reaction:
    EC 2.5.1.9?  ExPASy
    Riboflavin synthase 2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine
  • TIGRFAM:
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Riboflavin, FMN, and FAD riboflavin synthase, alpha subunit (TIGR00187; EC 2.5.1.9; HMM-score: 255.4)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    FAD_Lum_binding (CL0076) Lum_binding; Lumazine binding domain (PF00677; HMM-score: 172.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9866
    • Cytoplasmic Membrane Score: 0.0012
    • Cell wall & surface Score: 0.0003
    • Extracellular Score: 0.0119
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.014434
    • TAT(Tat/SPI): 0.000283
    • LIPO(Sec/SPII): 0.000924
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000493842 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MFTGIIEEIGKVERIQKDSRNCKLSIKASKILTDIHLGDSIAVNGICLTVTHFNHQSFTVDVMNETWSRTALTLLKHGSEVNLERALSVNGRLGGHVVTGHIDGTGKISSIKKDDNAVWYQINTQKEILDLIVEKGSITIDGISLTVAKVSKVNFSVSVIPHTLEQTILKSKQVGSTVNLENDILGKYVQKLMDNSPKSEISKELLYQNGF

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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