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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 13-OCT-2024

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae NCTC7465
  • locus tag: AT689_RS08180 [old locus tag: ERS445053_01601 ]
  • pan locus tag?: PNEUPAN002298000
  • symbol: zmpD
  • pan gene symbol?: zmpD
  • synonym:
  • product: zinc metalloprotease D

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: AT689_RS08180 [old locus tag: ERS445053_01601 ]
  • symbol: zmpD
  • product: zinc metalloprotease D
  • replicon: chromosome
  • strand: +
  • coordinates: 1536210..1541627
  • length: 5418
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_LN831051 (1536210..1541627) NCBI
  • BioCyc: AT689_RS08180 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    2281
    2341
    2401
    2461
    2521
    2581
    2641
    2701
    2761
    2821
    2881
    2941
    3001
    3061
    3121
    3181
    3241
    3301
    3361
    3421
    3481
    3541
    3601
    3661
    3721
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    3841
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    3961
    4021
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    4141
    4201
    4261
    4321
    4381
    4441
    4501
    4561
    4621
    4681
    4741
    4801
    4861
    4921
    4981
    5041
    5101
    5161
    5221
    5281
    5341
    5401
    TTGTCATTATTAAAAAAAGATAAATTTTCCATTCGGAAAATAAAGGGTATTGTTGGTTCG
    GTATTCTTGGGGAGTCTTTTATTTGCACCGTCAGTTGTTGGTGCATCGACTTATCATTAC
    TTAGATTATAGTAGTTTGACACAAACTGAACGTGATCAACTCAAACAAGGTAGACCTGAT
    GAATCCAAAGAGTCATATGCTTTGGATTATGAAAAAGACGCACTACCAAACACAGGAAGT
    TCTCAATCTATTATGACTGCATTGGGTTTGTTAGCTATCGGGAGTCTTATTGTGATTATC
    ACAAAAGATAATAGAAATAAAAAAATAGCTACATTTTTGATTGTAGGGGCGACAGGTTTA
    GTTACACTATCAACTGCTTCAGCACTTAATTTGAATGCTAACATCCATGAGTCTGGACGT
    GATGGTGTGTTGCAAATTTCTGGTTACAGATATGTTGGTTACTTGGAGCTTGATGATAAA
    ACTGTTTCGTCGGTTTCTCCAGCATCAACTGTTTCGCCAGTTGAGCAACCCAAAGTTGTA
    ACAGAGAAAGGCGAACCGGAAGTACAACCAGCTTTACCCGAAGCTGTTGTAACCGACAAA
    GGGGAATCTGAGATTCAAGCAGAATTGCCAGTAGCCGTAGTCTCAGAAAAGGTAGAATCA
    GCAGTTCAACCATCCTTACCAGAAGCAATAGTCACTGAAAAGGGGGAACCAGAAGTTCAA
    CCAGTGTTACCCGAAGCTGTTGTAACCGACAAAGGCGAACCGGAAGTTCATGAGAAGCCT
    GACTATACGCAACCAATAGGTGCAAACCTTGTTGAGCCTGAAGTTCATGAGAAACTAGCA
    TACACTGAACCAGTAGGGACAACAGGAGTAGATGAAAATGGAAACTTGATTGAACCACCT
    GTTAACGACATCCCAGAATATACTGAGCCAGTAGGTACAACAGGAGTGGATGAAAATGGA
    AACTTGATTGAGCCACCTGTTAGCGACATTCCAGAGTATACTGAACCAATATCTACAGTT
    TCAGAAGTTGCATCAGAAAGAGAAGAGTTGCCTTCTTTACATACCGATATTCGGACAGAG
    ACTATTCCTAAAACCACTATAGAAGAATCTGATCCTAGCAAATTTATAGGCGATGATTCT
    GTTAGACAAGTTGGTGAGGATGGCGAACGTCAAATTGTTACTAGCTATGAAGAGTTACAT
    GGCAAAAAAATCAGTGACCCAGTTGAAACAGTAACTATTTTGAAAGAAATGAAGCCTAAA
    ATTCTTGTAAAAGGTACCAAAGAAAAACCTAAAGAAAAAACGGCTCCTGTTTTGACCTTA
    GATAGAACAAATACAAATGTATTAAACCGATCCGCAACTCTTTCTTATCATTTAGTTAAT
    ACAGATGGAGTCACAATCAATAAAATTACTGCGACAATTAAAGATGGAAATGAAATTGTC
    AAAACAGTAGATTTGACTTCAGAGCAATTAGATAAGCAGGTAGAAGATTTAAAATTCTAC
    AAGGACTATAAGATAGAGACCACTATGACCTATGACCGTGGCAAGGGAGAAGAAACTGCA
    ACATTAGAAGAGAAACCACTTCGCTTGGATTTGAAAAAAGTTGAAATTAAAAATATCGCA
    TCTACTAATTTAGTGAAGGTAAATGACGATGGTACTGAAACACCTAGTGATTTTATGACT
    GAAAAACCTTCAGATGAAGATGTGAAGAAAATGTACTTAAAAATTACTAGTCGTGATAAT
    AAAGTAACACGTTTAGCAGTTGATAAAATTGAAGAAGTGACTGAAGAAGGTAAGAAACTT
    TATAAAATCACTGCCGAAGCTCAAGATTTGATTCAACATACAGACCCAACGAAGGTTCGT
    AACAAGTATGTTCATTATATTGAAAAACCAGTTCCAAAAGTTGATGACGTTTATTATAAC
    TTTAAAGAGTTAGTAGATGCCATGAATGCTGATAAAAATGGTACATTTAAAATCGGAGCA
    GATTTGAATGCAACGAATGTACCAACACCTAACAAACAATATGTTCCAGGTACGTTTAAG
    GGACATCTATCAAGTGTTGATGGTAAACAATATACAATTCATAACATTGCCCGTCCCTTA
    TTTGACCGTGTTGAAAATGGTTCTGTGAAAAATATTAATTTAGGTAATGTGGATATCAAT
    ATGCCTTGGGCTGACGGAATAGCACCTGTTGCCAATATGGTGAAAAATGCAACTGTTGAA
    GATGTTAAGGTAACTGGTAATGTAGTTGCTAATAACAATATTGCGGGTATCGTCAATAAA
    ATCGATAGTGGTGGTCAGTTGACAAATGTAGCCTTCATCGGTAATCTTACAGGTGTTGGT
    GATAAAGGTCAATATATGGCTGGCATTGCCGGTGAGATTTGGAGAGGTAATCTTGCAAAA
    GCATATGTCGAGGCTGATATTGTTGCTAACAGAGCCCGTATAGGTGGTTTAGTTGCTAAA
    ACAGATAATGGTAACGACTCTATGGGAATTGGTAAATACGGTTCAATTCGTAAATCAGTC
    ACCAAAGGAACCATTAAGACTAAAGTTTTGTTTGAAACAGGTGGATTTATCAATAGCAAT
    CTTCCTTTTGGTAAACTTGAAGATAATATTTCAATGATGAGAGTTGAAAATGGTGAAGAG
    TTCTTTGGTTCTTCCGATTTGGACTACGATGGTGGTTATTTCACAAATGGCTGGTTAGAG
    CGTAACTTTGTTGTCAAAGGTGTCAGTTCAGGTAAGCATTCATACAAACGTTCTCGTGAC
    AAAATTAAAGAAATTAGTCAAGATGAAGCTAATAAGAGAATTGCAAATTTTGGACTTACT
    GCTGATAAATACGAAATCAACGAACCTGTGGTCAATCGCTTAAATCGTTTAACCAGAAGA
    GAAGATGAATATAAGTCAACTCAAGACTACAAATCCGAACGTGATTTAGCTTATCGTAAT
    ATTGAGAAACTTCAACCATTTTATAATAAAGAATGGATTGTCAACCAAGGTAACAAACTT
    GCAGAAGATTCAAACTTAGCTAAGAAAGAAGTCCTTTCTGTTACGGGGATGAAGGATGGT
    CAATTCGTGACCGATTTATCAGATATTGATAAGATTATGGTTCACTATGCTGATGGTACT
    AAGGAAGAAATGGATGTTACTAAGAATACTGATTCTAAAGTCCAACAAGTGCGTGAATAT
    AGTGTATCTGGTCTTGGTGATGTTGTTTATACACCGAATATGGTTGTTAAAAATCGTGAT
    AAATTGATTGCTGATGTTAAATCTCAATTATCAAGTGTGGAATTGATTTCACAAGAAGTA
    AGAGATTTAATGAGTAGACGTGATAAACCTGCAGAGAATACGGATGAACGTAAGAATGGT
    TATATTAAAGATCTATACTTAGAAGAAAGCTTTGCCGAAGTGAAGCAAAATCTAGATAAG
    TTAGTCAAATCCTTGGTCGAAAATGAAGACCATCAATTGAATGGTGATGAAGCTGCGATA
    AAATCACTTCTCAAGAAAGTGGAAACCAATAAAGCTAAAATCATGATGGCTCTGACTTAT
    CTCAATCGTTACTATGATATCAAATACGGTGACATAAGTATAAAAAACATCATGATGTTC
    AAACCTGATTTTTATGGTAAAACACCAAGTGTTATTGACAGACTCATCAACATCGGTTCA
    AGTGAAAAGAACTTGAAAGGGGATCGGACTCAGGATGCTTACCGTGAAATCATCGCAGGT
    AATACTGGTAAAAGTAATTTGCGTAACTTCTTAGAATACAACATGCGTCTGTTTACAGAG
    GATAAAGACATCAATGATTGGTTTATCCACTCAGCTAAGAATGTTTATGTTTCAGAACCT
    AAGACAACAAATACAGAGTTGAAAGATAAACGTCATCGTGTGTTCGATGGTTTAGATAAC
    GGTGTTCATGGTCGTATGATTTTACCACTTCTAACGCTTAAAGATGCCCATATGTTCTTA
    ATTTCAACATATAACACGATGGCGTACAGTTCATTTGAGAAATATGGAAAACATACAGAA
    GAAGCTCGTAATGAGTTCAAAACTAAGATTGATGAAGTTGCACATGCTCAACAAACTTAT
    TTAGATTTCTGGTCCAGATTAGCTCTGCCTAATGTTCGTGATAGACTTCTTAAGAGTCAA
    AATATGGTACCGACACCAGTTTGGGATAACCAGACCTACAATGGTTCTCCTGTAGGTCGT
    CGAGGATTTGACAGTAAAGGTAACCCTATAGCTCCAATTCGTGAATTATATGGTCCAACA
    TGGCGACACCATGATAGAGACTGGCGTATGGGCGCTATGGCATCAATATTCCCTAATCCA
    AATAATGATGACAAGGTCTTGTTTATGGTGACGGATATGATTAGCCCATTTGGTATTTCA
    GCCTTTACTCACGAAACAACACACGTAAACGATAGAATGCTTTACTTCGGTGGTCATAAG
    CATCGTCAAGGTACAGACGTTGAAGCCTATGCTCAAGGTATGTTGCAAACACCTGACAGC
    TCAACGACTAATGGTGAATACGGCGCACTTGGAATTAACATGGCTTACCATCGTCCAAAT
    GATGGTAACCAATGGTACAACCCAGATCCTGACAAATTAAAGACACGTGATGACATTGAC
    CGCTACATGAGAAACTACAATGAAGCTATGATGTTGCTTGATCATGTAGAAGCTGATGCT
    GTACTTCCTAAAATTAAAGGAGACAATAGTAAGTGGTTCAAGAAGATTGACAAAGAAATG
    CGCTCTAAGATTCAGTATAATGATCTTTTAGGTCCAAACCAATGGGATAGTATCCGTGAT
    TTGAAAGATGAAGAAAAGGTAATGACTTTATCTAGCGTCAATGATTTAGTGGATAATAAC
    TTCATGACAAAACATGGAAATCCAGGTAATGGACGTTATAGACCAGAAGATTTTACACCA
    AACTCAGCTTACGTAAATGTCAATATGATGGCAGGAATTTACGGTGGGAATACGAGTCAA
    GGTGCTCCTGGTTCATTATCATTTAAGCACAATGCTTTCCGTATGTGGGGCTATTATGGT
    TATGAAAATGGCTTTATTAGTTATGTATCAAATAAATACAAAGCAGAAGCAGATAAAAAC
    AACCACGGTTTACTAAGCGATAAGCTAATAATTAATAAAGTATCGAAAGGAAACTTTAAT
    ACTCTTGAAGAGTGGAAGAGACATTGGTACGGGGAAGTTCTTGCTAAAGCTAAGAAAGGT
    TTTGAGGCTATCGATATTGATGGCGTCCATATCAGTAACTATGATGAGTTAAGGCCTTTA
    TTTGATAAAGCAGTTGAAGAAGATTTGAAGAAACCAGATGACTTCTCTCACACTGTTGCT
    CTTAAATCTAAGGTCTTCAAAGCCCTTCTTAAAAACACAGACGGTTTCTTTAATAAACTG
    TTTAAAGAAGACATTTAA
    60
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    180
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    3000
    3060
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    3180
    3240
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    3360
    3420
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    3960
    4020
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    4140
    4200
    4260
    4320
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    4800
    4860
    4920
    4980
    5040
    5100
    5160
    5220
    5280
    5340
    5400
    5418

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: AT689_RS08180 [old locus tag: ERS445053_01601 ]
  • symbol: ZmpD
  • description: zinc metalloprotease D
  • length: 1805
  • theoretical pI: 5.51998
  • theoretical MW: 202572
  • GRAVY: -0.612299

⊟Function[edit | edit source]

  • TIGRFAM:
    Cell structure Cell envelope Other LPXTG cell wall anchor domain (TIGR01167; HMM-score: 19.8)
  • TheSEED:
  • PFAM:
    no clan defined Peptidase_M26_C; M26 IgA1-specific Metallo-endopeptidase C-terminal region (PF07580; HMM-score: 826.3)
    and 6 more
    Peptidase_M26_N; M26 IgA1-specific Metallo-endopeptidase N-terminal region (PF05342; HMM-score: 267.6)
    G5 (CL0593) G5; G5 domain (PF07501; HMM-score: 36.7)
    no clan defined Gram_pos_anchor; LPXTG cell wall anchor motif (PF00746; HMM-score: 19.7)
    KNTase_C (CL0291) HEPN_Cthe2314; Cthe_2314-like HEPN (PF18730; HMM-score: 17.1)
    no clan defined Pectate_lyase_5; Putative pectate lyase-like adhesive domain (PF20585; HMM-score: 12.6)
    YSIRK_signal; YSIRK type signal peptide (PF04650; HMM-score: 8.5)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cellwall
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 10
    • Extracellular Score: 0
    • Internal Helices: 2
  • DeepLocPro: Cell wall & surface
    • Cytoplasmic Score: 0.0003
    • Cytoplasmic Membrane Score: 0.0186
    • Cell wall & surface Score: 0.8792
    • Extracellular Score: 0.1019
  • SignalP: Signal peptide SP(Sec/SPI) length 35 aa
    • SP(Sec/SPI): 0.860775
    • TAT(Tat/SPI): 0.019935
    • LIPO(Sec/SPII): 0.012019
    • Cleavage Site: CS pos: 35-36. VGA-ST. Pr: 0.5872
  • predicted transmembrane helices (TMHMM): 3

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000054799 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MSLLKKDKFSIRKIKGIVGSVFLGSLLFAPSVVGASTYHYLDYSSLTQTERDQLKQGRPDESKESYALDYEKDALPNTGSSQSIMTALGLLAIGSLIVIITKDNRNKKIATFLIVGATGLVTLSTASALNLNANIHESGRDGVLQISGYRYVGYLELDDKTVSSVSPASTVSPVEQPKVVTEKGEPEVQPALPEAVVTDKGESEIQAELPVAVVSEKVESAVQPSLPEAIVTEKGEPEVQPVLPEAVVTDKGEPEVHEKPDYTQPIGANLVEPEVHEKLAYTEPVGTTGVDENGNLIEPPVNDIPEYTEPVGTTGVDENGNLIEPPVSDIPEYTEPISTVSEVASEREELPSLHTDIRTETIPKTTIEESDPSKFIGDDSVRQVGEDGERQIVTSYEELHGKKISDPVETVTILKEMKPKILVKGTKEKPKEKTAPVLTLDRTNTNVLNRSATLSYHLVNTDGVTINKITATIKDGNEIVKTVDLTSEQLDKQVEDLKFYKDYKIETTMTYDRGKGEETATLEEKPLRLDLKKVEIKNIASTNLVKVNDDGTETPSDFMTEKPSDEDVKKMYLKITSRDNKVTRLAVDKIEEVTEEGKKLYKITAEAQDLIQHTDPTKVRNKYVHYIEKPVPKVDDVYYNFKELVDAMNADKNGTFKIGADLNATNVPTPNKQYVPGTFKGHLSSVDGKQYTIHNIARPLFDRVENGSVKNINLGNVDINMPWADGIAPVANMVKNATVEDVKVTGNVVANNNIAGIVNKIDSGGQLTNVAFIGNLTGVGDKGQYMAGIAGEIWRGNLAKAYVEADIVANRARIGGLVAKTDNGNDSMGIGKYGSIRKSVTKGTIKTKVLFETGGFINSNLPFGKLEDNISMMRVENGEEFFGSSDLDYDGGYFTNGWLERNFVVKGVSSGKHSYKRSRDKIKEISQDEANKRIANFGLTADKYEINEPVVNRLNRLTRREDEYKSTQDYKSERDLAYRNIEKLQPFYNKEWIVNQGNKLAEDSNLAKKEVLSVTGMKDGQFVTDLSDIDKIMVHYADGTKEEMDVTKNTDSKVQQVREYSVSGLGDVVYTPNMVVKNRDKLIADVKSQLSSVELISQEVRDLMSRRDKPAENTDERKNGYIKDLYLEESFAEVKQNLDKLVKSLVENEDHQLNGDEAAIKSLLKKVETNKAKIMMALTYLNRYYDIKYGDISIKNIMMFKPDFYGKTPSVIDRLINIGSSEKNLKGDRTQDAYREIIAGNTGKSNLRNFLEYNMRLFTEDKDINDWFIHSAKNVYVSEPKTTNTELKDKRHRVFDGLDNGVHGRMILPLLTLKDAHMFLISTYNTMAYSSFEKYGKHTEEARNEFKTKIDEVAHAQQTYLDFWSRLALPNVRDRLLKSQNMVPTPVWDNQTYNGSPVGRRGFDSKGNPIAPIRELYGPTWRHHDRDWRMGAMASIFPNPNNDDKVLFMVTDMISPFGISAFTHETTHVNDRMLYFGGHKHRQGTDVEAYAQGMLQTPDSSTTNGEYGALGINMAYHRPNDGNQWYNPDPDKLKTRDDIDRYMRNYNEAMMLLDHVEADAVLPKIKGDNSKWFKKIDKEMRSKIQYNDLLGPNQWDSIRDLKDEEKVMTLSSVNDLVDNNFMTKHGNPGNGRYRPEDFTPNSAYVNVNMMAGIYGGNTSQGAPGSLSFKHNAFRMWGYYGYENGFISYVSNKYKAEADKNNHGLLSDKLIINKVSKGNFNTLEEWKRHWYGEVLAKAKKGFEAIDIDGVHISNYDELRPLFDKAVEEDLKKPDDFSHTVALKSKVFKALLKNTDGFFNKLFKEDI

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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