PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 09-DEC-2016

⊟Summary

• organism: Streptococcus pneumoniae SP49
• locus tag: BMJ42_00215 [new locus tag: BMJ42_RS01130 ]
• pan locus tag^?: PNEUPAN000789000
• symbol: BMJ42_00215
• pan gene symbol^?: artP_1
• synonym:
• product: amino acid ABC transporter periplasmic amino acid-binding protein

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: BMJ42_00215 [new locus tag: BMJ42_RS01130 ]
• symbol: BMJ42_00215
• product: amino acid ABC transporter periplasmic amino acid-binding protein
• replicon: chromosome
• strand: +
• coordinates: 183996..184802
• length: 807
• essential: unknown

⊟Accession numbers

• Location: CP018136 (183996..184802) NCBI
• BioCyc: see BMJ42_RS01130
• MicrobesOnline:
• PneumoBrowse for strain D39V: SPV_0109 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
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  481
  541
  601
  661
  721
  781
  
  ATGAATAAGATGAAGAAGGTGTTGATGACGATGTTTGGTTTAGTGATGCTCCCCCTACTA
  TTTGCTTGTAGTAACAATCAATCGGCTGGAATTGAAGCCATCAAGTCCAAAGGAAAATTG
  GTTGTAGCCCTCAATCCAGATTTTGCTCCATTTGAATATCAAAAAGTGGTTGATGGGAAA
  AATCAGATTGTGGGTTCAGATATCGAATTAGCCAAGGCTATCGCAACAGAACTAGGTGTC
  GAATTGGAACTATCTCCTATGAGTTTTGACAATGTACTGGCTAGCGTTCAATCAGGAAAA
  GCTGACCTTGCCATATCAGGTGTTTCTAAGACAGATGAACGGAGCAAGGTGTTTGATTTT
  TCAACTCCCTACTATACTGCAAAAAATAAACTCATTGTCAAAAAATCTGATTTAGCCACT
  TATCAGTCTGTCAACGATTTGGCGCAGAAAAAGGTCGGAGCGCAGAAAGGTTCGATTCAA
  GAGACGATGGCGAAAGATTTGCTACAAAATTCTTCCCTCGTATCTCTGCCTAAAAATGGG
  AATTTAATCACAGATTTAAAATCAGGGCAAGTGGATGCCGTTATTTTTGAAGAACCCGTT
  GCCAAGGGATTTGTGGAAAATAATCCTGATTTAGCAATCGCAGACCTCAATTTTGAAAAA
  GAGCAAGATGATTCCTATGCGGTAGCCATGAAAAAAGATAGCAAGGAATTGAAAGAGGCA
  GTCGATAAAACCATTCAAAAGTTGAAGGAGTCTGGGGAATTAGACAAACTCATTGAGGAT
  GCCTTTAAAGCATCCATTGAAAAATAG
  60
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  807
  

⊟Protein

⊟General

• locus tag: BMJ42_00215 [new locus tag: BMJ42_RS01130 ]
• symbol: BMJ42_00215
• description: amino acid ABC transporter periplasmic amino acid-binding protein
• length: 268
• theoretical pI: 4.95365
• theoretical MW: 29208.4
• GRAVY: -0.219776

⊟Function

• TIGRFAM:
  Metabolism Transport and binding proteins Amino acids, peptides and amines lysine-arginine-ornithine-binding periplasmic protein (TIGR01096; HMM-score: 155.8)
  and 6 more
  Metabolism Transport and binding proteins Amino acids, peptides and amines ectoine/hydroxyectoine ABC transporter solute-binding protein EhuB (TIGR02995; HMM-score: 74.9)
  extracellular substrate-binding orphan protein, GRRM family (TIGR04262; HMM-score: 45.8)
  quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein (TIGR03871; HMM-score: 39.8)
  Metabolism Transport and binding proteins Other ABC transporter, substrate-binding protein, aliphatic sulfonates family (TIGR01728; HMM-score: 24.1)
  Metabolism Amino acid biosynthesis Histidine family ATP phosphoribosyltransferase (TIGR00070; EC 2.4.2.17; HMM-score: 13)
  Hypothetical proteins Conserved conserved hypothetical protein (TIGR02285; HMM-score: 12.3)
• TheSEED: data available for D39, Hungary19A-6, TIGR4
• PFAM:
  PBP (CL0177) SBP_bac_3; Bacterial extracellular solute-binding proteins, family 3 (PF00497; HMM-score: 204.4)
  and 5 more
  Lig_chan-Glu_bd; Ligated ion channel L-glutamate- and glycine-binding site (PF10613; HMM-score: 31.5)
  NMT1; NMT1/THI5 like (PF09084; HMM-score: 26)
  no clan defined PMC2NT; PMC2NT (NUC016) domain (PF08066; HMM-score: 15.8)
  PBP (CL0177) LysR_substrate; LysR substrate binding domain (PF03466; HMM-score: 13)
  PBP_like; PBP superfamily domain (PF12727; HMM-score: 11.5)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: unknown (no significant prediction)
  • Cytoplasmic Score: 2.5
  • Cytoplasmic Membrane Score: 2.5
  • Cellwall Score: 2.5
  • Extracellular Score: 2.5
  • Internal Helices: 0
• SignalP: Signal peptide LIPO(Sec/SPII) length 22 aa
  • SP(Sec/SPI): 0.002989
  • TAT(Tat/SPI): 0.000081
  • LIPO(Sec/SPII): 0.996676
  • Cleavage Site: CS pos: 22-23. LFA-CS. Pr: 0.9972
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: APJ29555 NCBI
• UniProt:

⊟Protein sequence

• MNKMKKVLMTMFGLVMLPLLFACSNNQSAGIEAIKSKGKLVVALNPDFAPFEYQKVVDGKNQIVGSDIELAKAIATELGVELELSPMSFDNVLASVQSGKADLAISGVSKTDERSKVFDFSTPYYTAKNKLIVKKSDLATYQSVNDLAQKKVGAQKGSIQETMAKDLLQNSSLVSLPKNGNLITDLKSGQVDAVIFEEPVAKGFVENNPDLAIADLNFEKEQDDSYAVAMKKDSKELKEAVDKTIQKLKESGELDKLIEDAFKASIEK

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• data available for TIGR4

⊟Expression data

• PneumoExpress for strain D39V: SPV_0109 PneumoExpress

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications