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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 09-DEC-2016

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae SP49
  • locus tag: BMJ42_00467 [new locus tag: BMJ42_RS02465 ]
  • pan locus tag?: PNEUPAN001178000
  • symbol: rmlD
  • pan gene symbol?: cps2O
  • synonym: rfbD
  • product: dTDP-4-keto-L-rhamnose reductase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: BMJ42_00467 [new locus tag: BMJ42_RS02465 ]
  • symbol: rmlD
  • product: dTDP-4-keto-L-rhamnose reductase
  • replicon: chromosome
  • strand: -
  • coordinates: 411428..412282
  • length: 855
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    ATGATCTTAATTACAGGTGCAAATGGTCAACTTGGTACCGAACTACGTTATTTACTAGAT
    GAGCGAAATGTGGACTATGTTGCAGTGGATGTGACCGAAATGGATATCACTAATTCTGAA
    ATGGTTGAAAAAGTCTTTGCTGAGGTTAAGCCAACTCTAGTCTATCATTGTGCAGCCTAC
    ACTGCTGTTGATGCAGCCGAAGATGAAGGGAAAGAACTGGATTTTGCCATCAACGTAACT
    GGAACTGAAAATGTAGCCAAGGCCTCTGAGAAATACGGAGCTATTCTGGTCTATATCTCA
    ACAGACTACGTCTTTGATGGAAAGAAACCAGTAGGACAAGAGTGGGAAGTCGATGACATA
    CCTGATCCGCAAACAGAGTACGGACGTACCAAGCGAATGGGAGAAGAACTTGTTGAAAAC
    CTTACGTCACAGCATTACATCATTCGTACTGCTTGGGTTTTTGGAAATTATGGAAAAAAC
    TTTGTCTTTACCATGCAAAGCCTAGCCAAAACCCATAAAACGCTCACAGTGGTCAACGAC
    CAATACGGTCGCCCAACTTGGACACGGACCTTGGCCGAATTCATGACCTATGTGACTGAA
    AATCAAAAAGAGTATGGCTACTATCACTTATCAAATGACGCAGCTGAAGACACCACTTGG
    TATGACTTTGCTAGCGAGATTCTTAAGGACAGTGATGTTGAAGTAGTGCCAGTAGACTCT
    AGCAAGTTCCCCGCTAAGGCTAAACGACCTCTCAACTCAACTATGAGTTTGGCAAAGGCA
    AAGGCAACAGGTTTCGTCATCCCAACCTGGCAAGATGCCCTTAAAGAGTTTTATAAACAA
    GAAGTAAGAAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    855

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: BMJ42_00467 [new locus tag: BMJ42_RS02465 ]
  • symbol: RmlD
  • description: dTDP-4-keto-L-rhamnose reductase
  • length: 284
  • theoretical pI: 4.51065
  • theoretical MW: 32230
  • GRAVY: -0.424648

⊟Function[edit | edit source]

  • TIGRFAM:
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides dTDP-4-dehydrorhamnose reductase (TIGR01214; EC 1.1.1.133; HMM-score: 272.5)
    and 10 more
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides dTDP-glucose 4,6-dehydratase (TIGR01181; EC 4.2.1.46; HMM-score: 36.6)
    Metabolism Energy metabolism Sugars UDP-glucose 4-epimerase GalE (TIGR01179; EC 5.1.3.2; HMM-score: 35.3)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides CDP-glucose 4,6-dehydratase (TIGR02622; EC 4.2.1.45; HMM-score: 30.7)
    thioester reductase domain (TIGR01746; HMM-score: 27.2)
    hopanoid-associated sugar epimerase (TIGR03466; HMM-score: 21.3)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides ADP-glyceromanno-heptose 6-epimerase (TIGR02197; EC 5.1.3.20; HMM-score: 19.3)
    NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family (TIGR04180; HMM-score: 17.1)
    Metabolism Energy metabolism Biosynthesis and degradation of polysaccharides 2-deoxy-D-gluconate 3-dehydrogenase (TIGR01832; EC 1.1.1.125; HMM-score: 16.1)
    Genetic information processing Protein fate Protein modification and repair anaerobic ribonucleoside-triphosphate reductase activating protein (TIGR02495; EC 1.97.-.-; HMM-score: 12.8)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides 2'-Deoxyribonucleotide metabolism anaerobic ribonucleoside-triphosphate reductase activating protein (TIGR02495; EC 1.97.-.-; HMM-score: 12.8)
  • TheSEED: data available for D39, Hungary19A-6
  • PFAM:
    NADP_Rossmann (CL0063) RmlD_sub_bind; RmlD substrate binding domain (PF04321; HMM-score: 354.4)
    and 10 more
    Epimerase; NAD dependent epimerase/dehydratase family (PF01370; HMM-score: 89.2)
    GDP_Man_Dehyd; GDP-mannose 4,6 dehydratase (PF16363; HMM-score: 49.9)
    Polysacc_synt_2; Polysaccharide biosynthesis protein (PF02719; HMM-score: 47)
    3Beta_HSD; 3-beta hydroxysteroid dehydrogenase/isomerase family (PF01073; HMM-score: 43.2)
    NAD_binding_4; Male sterility protein (PF07993; HMM-score: 39.4)
    Semialdhyde_dh; Semialdehyde dehydrogenase, NAD binding domain (PF01118; HMM-score: 14.9)
    Thioredoxin (CL0172) Glutaredoxin; Glutaredoxin (PF00462; HMM-score: 12.9)
    NADP_Rossmann (CL0063) adh_short; short chain dehydrogenase (PF00106; HMM-score: 12.7)
    DapB_N; Dihydrodipicolinate reductase, N-terminus (PF01113; HMM-score: 12.3)
    KR; KR domain (PF08659; HMM-score: 12)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9936
    • Cytoplasmic Membrane Score: 0.0023
    • Cell wall & surface Score: 0.0002
    • Extracellular Score: 0.0039
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.002445
    • TAT(Tat/SPI): 0.000148
    • LIPO(Sec/SPII): 0.000354
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: APJ29802 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MILITGANGQLGTELRYLLDERNVDYVAVDVTEMDITNSEMVEKVFAEVKPTLVYHCAAYTAVDAAEDEGKELDFAINVTGTENVAKASEKYGAILVYISTDYVFDGKKPVGQEWEVDDIPDPQTEYGRTKRMGEELVENLTSQHYIIRTAWVFGNYGKNFVFTMQSLAKTHKTLTVVNDQYGRPTWTRTLAEFMTYVTENQKEYGYYHLSNDAAEDTTWYDFASEILKDSDVEVVPVDSSKFPAKAKRPLNSTMSLAKAKATGFVIPTWQDALKEFYKQEVRK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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