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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 15-OCT-2021

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae SP49
  • locus tag: BMJ42_RS10725 [old locus tag: BMJ42_02034 ]
  • pan locus tag?: PNEUPAN003543000
  • symbol: BMJ42_RS10725
  • pan gene symbol?: rr11
  • synonym:
  • product: response regulator transcription factor

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: BMJ42_RS10725 [old locus tag: BMJ42_02034 ]
  • symbol: BMJ42_RS10725
  • product: response regulator transcription factor
  • replicon: chromosome
  • strand: -
  • coordinates: 1935470..1936069
  • length: 600
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_CP018136 (1935470..1936069) NCBI
  • BioCyc: BMJ42_RS10725 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1798 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    ATGAAAGTATTAGTCGCAGAAGATCAAAGTATGTTGCGAGATGCCATGTGTCAATTGCTC
    ACGCTTCAACCAGATGTGGAGTCTGTCCTTCAAGCCAAGAATGGGCAAGAAGCAATCCAA
    CTATTAGAAAAGGAGTCTGTAGATATCGCCATCCTTGACGTAGAAATGCCTGTTAAGACA
    GGTCTTGAAGTCTTGGAGTGGATACGATCAGAAAGGCTTGAAACAAAGGTGGTTGTGGTG
    ACGACCTTCAAGCGTGCTGGGTATTTTGAACGTGCGGTCAAGGCTGGAGTGGATGCTTAT
    GTATTAAAGGAACGAAGCGTTGCAGACCTCATGCAAACCTTGCACACCGTCCTCGAAGGA
    CGCAAGGAGTATTCGCCTGAATTGATGGAAGTGGTGATGACCCGTCCCAATCCGTTGACA
    GAACAAGAGATTGCTGTCTTAAAGGGGATCGCCCGGGGCTTATCCAACCAAGAAATCGCA
    GATCAGCTTTACCTCTCAAACGGAACTATTCGAAACTATGTCACCAATATTCTTTCAAAA
    TTGGATGCTGGTAATCGAACAGAGGCAGCTAATATCGCAAAAGAATCTGGTTGGTTATGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: BMJ42_RS10725 [old locus tag: BMJ42_02034 ]
  • symbol: BMJ42_RS10725
  • description: response regulator transcription factor
  • length: 199
  • theoretical pI: 4.65392
  • theoretical MW: 22247.5
  • GRAVY: -0.120603

⊟Function[edit | edit source]

  • TIGRFAM:
    Cellular processes Cellular processes Sporulation and germination sporulation transcription factor Spo0A (TIGR02875; HMM-score: 61.1)
    and 15 more
    Signal transduction Regulatory functions DNA interactions phosphate regulon transcriptional regulatory protein PhoB (TIGR02154; HMM-score: 43)
    Signal transduction Signal transduction Two-component systems phosphate regulon transcriptional regulatory protein PhoB (TIGR02154; HMM-score: 43)
    Signal transduction Regulatory functions DNA interactions heavy metal response regulator (TIGR01387; HMM-score: 41.3)
    transcriptional regulator EpsA (TIGR03020; HMM-score: 41)
    Metabolism Central intermediary metabolism Nitrogen metabolism nitrogen regulation protein NR(I) (TIGR01818; HMM-score: 31.9)
    Signal transduction Regulatory functions DNA interactions nitrogen regulation protein NR(I) (TIGR01818; HMM-score: 31.9)
    Signal transduction Signal transduction Two-component systems nitrogen regulation protein NR(I) (TIGR01818; HMM-score: 31.9)
    Signal transduction Signal transduction Two-component systems TMAO reductase sytem sensor TorS (TIGR02956; EC 2.7.13.3; HMM-score: 31.5)
    LuxR family transcriptional regulatory, chaperone HchA-associated (TIGR03541; HMM-score: 23.7)
    RNA polymerase sigma factor, sigma-70 family (TIGR02937; HMM-score: 20.6)
    proteobacterial dedicated sortase system response regulator (TIGR03787; HMM-score: 20.2)
    RNA polymerase sigma-70 factor, Bacteroides expansion family 1 (TIGR02985; HMM-score: 19.4)
    Signal transduction Regulatory functions DNA interactions CRISPR locus-related DNA-binding protein (TIGR01884; HMM-score: 18.4)
    Signal transduction Regulatory functions DNA interactions PEP-CTERM-box response regulator transcription factor (TIGR02915; HMM-score: 16.2)
    Signal transduction Regulatory functions DNA interactions DNA-binding protein, Tfx family (TIGR00721; HMM-score: 13.4)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    CheY (CL0304) Response_reg; Response regulator receiver domain (PF00072; HMM-score: 86.7)
    and 10 more
    HTH (CL0123) GerE; Bacterial regulatory proteins, luxR family (PF00196; HMM-score: 65.7)
    CheY (CL0304) cREC_REC; Cyclic-phosphate processing Receiver domain (PF20274; HMM-score: 21.3)
    HTH (CL0123) Sigma70_r4_2; Sigma-70, region 4 (PF08281; HMM-score: 17.9)
    HTH_24; Winged helix-turn-helix DNA-binding (PF13412; HMM-score: 17.8)
    HTH_11; HTH domain (PF08279; HMM-score: 15.9)
    HTH_38; Helix-turn-helix domain (PF13936; HMM-score: 15.3)
    PBP (CL0177) LysR_substrate; LysR substrate binding domain (PF03466; HMM-score: 14.7)
    HTH (CL0123) Sigma70_r4; Sigma-70, region 4 (PF04545; HMM-score: 14.3)
    HTH_40; Helix-turn-helix domain (PF14493; HMM-score: 13.8)
    HTH_10; HTH DNA binding domain (PF04967; HMM-score: 12)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.003965
    • TAT(Tat/SPI): 0.000206
    • LIPO(Sec/SPII): 0.000541
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000866725 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKVLVAEDQSMLRDAMCQLLTLQPDVESVLQAKNGQEAIQLLEKESVDIAILDVEMPVKTGLEVLEWIRSERLETKVVVVTTFKRAGYFERAVKAGVDAYVLKERSVADLMQTLHTVLEGRKEYSPELMEVVMTRPNPLTEQEIAVLKGIARGLSNQEIADQLYLSNGTIRNYVTNILSKLDAGNRTEAANIAKESGWL

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Wolfgang Haas, Deepak Kaushal, Jack Sublett, Caroline Obert, Elaine I Tuomanen
Vancomycin stress response in a sensitive and a tolerant strain of Streptococcus pneumoniae.
J Bacteriol: 2005, 187(23);8205-10
[PubMed:16291696] [WorldCat.org] [DOI] (P p)Riana Cockeran, Jenny A Herbert, Timothy J Mitchell, Thérèse Dix-Peek, Caroline Dickens, Ronald Anderson, Charles Feldman
Exposure of a 23F serotype strain of Streptococcus pneumoniae to cigarette smoke condensate is associated with selective upregulation of genes encoding the two-component regulatory system 11 (TCS11).
Biomed Res Int: 2014, 2014;976347
[PubMed:25013815] [WorldCat.org] [DOI] (I p)

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