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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 12-FEB-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae NCTC7466
  • locus tag: DQM66_RS00875 [old locus tag: NCTC7466_00161 ]
  • pan locus tag?: PNEUPAN000870000
  • symbol: DQM66_RS00875
  • pan gene symbol?: yesM
  • synonym:
  • product: sensor histidine kinase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: DQM66_RS00875 [old locus tag: NCTC7466_00161 ]
  • symbol: DQM66_RS00875
  • product: sensor histidine kinase
  • replicon: chromosome
  • strand: +
  • coordinates: 161311..162981
  • length: 1671
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_LS483374 (161311..162981) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0157 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    ATGAAAAATTGGCGACAAAATAGAATGAAGCAGTTTTGGCTACATACGCTTCTAAGAACC
    TATAGTTCAGTGATGATCATTATCATTGCGAGTTTTGCAATCTTACTCTCTTACGCTGAC
    TGGGATTCACGTGAAAAGGAAGCCCAGAGAGTAGCCCAGCGTGTAACTGCTAGAACAGTG
    AGTGAAATTGAATATTACCATAGAGAGTCAACCCAGATAGCTCAGGCTTTAGTTGAAAAT
    CAAGCTCGTATCGAGGGAATCTATAAATACTTTAGCCTTAGCATGCCAGACTATTTTTAC
    TGGCAATTAGAGCGGAAAGCTTCGCCTTATATATCAGTCTCTCTGTATGAAAATGTTGAT
    GACCTCTATGTTCGAAATGATTTTGTAACTGGGGTGGCCATTGCTTTTCAAGATTACAAG
    GAAGTCTATGTTTCTACTAAAGACAAACGTAGTGGAGAAAAAATCAGGGCTGAGGATTTC
    AAACCAGCAGGAAATAGTTTTGCCATTCCGGTGTCAGATCCAGTGTCAGATCAAGATTTA
    GGAGTGATTTACATCTCCTTGGATCCTGCTGTTTTATACCATGCCATTGATAATACTAGA
    GGTCATACTCCGATGGCAGTAACAGTGACCTCACCTTTTGATACGGAGATTTTTCATATT
    GGTGAGACAGTTGATAGGGAGAGTGAAAATTGGCTAGTTGGCTTAACTTCTCATGGATAT
    CAGGTTCAGGTGGCAGTTCCTAAAAACTTTGTTTTACAAGGAACAGTGACTAGCTCTGCT
    TTGATTGTGGGTTTGAGCCTTCTCTTTATTGTCATTCTTTATCTGACTTTGAGGCAGACT
    TTTGCTAATTACCAAAAGCAGGTAGTGGATTTAGTAGAATCCATTCAAGTCATTGCTCAA
    GGCGAAGAGGGGCGTCGGATTGACATTTCCGAGAAAGATCAGGAATTACTCCTAATCGCG
    GAGACGACCAATGATATGTTGGATCGATTGGAAAAGAATATCCATGATATTTACCAGTTA
    GAGCTTAGTCAAAAAGATGCCAATATGCGAGCCTTGCAGGCGCAAATCAATCCTCATTTT
    ATGTATAATACGCTGGAGTTCTTGCGCATGTATGCAGTTATGCAGAGTCAAGATGAGTTG
    GCAGATATCATTTATGAATTCAGTAGTCTCTTGCGTAACAATATTTCCGACGAAAGAGAG
    ACCCTCCTCAAACAGGAATTAGAATTTTGCCGTAAATACAGCTATCTCTGCATGGTTCGC
    TATCCCAAGTCCATTGCCTATGGTTTCAAGATAGATCCAGAGTTAGAGAATATGAAGATT
    CCCAAGTTTACCTTGCAACCGCTGGTAGAAAACTATTTCGCGCATGGTGTTGACCACAGG
    CGGACAGATAATGTGATTAGCATCAAGGCTCTTAAACAGGATGGTTTTGTGGAAATTTTG
    GTGGTCGATAATGGTAGAGGAATGTCGGCTGAAAAGTTGGCAAATATCCGAGAAAAATTA
    AGTCAGAAATATTTTGAACACCAAGCCAGCTACAGTGATCAAAGGCAGTCTATCGGGATT
    GTCAATGTACACGAGCGTTTTGTGCTCTATTTTGGAGACCGCTATGCCATTACTATAGAG
    TCTGCAGAGCAAGCCGGTGTTCAGTATCGTATTACAATTCAAGATGAGTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1671

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: DQM66_RS00875 [old locus tag: NCTC7466_00161 ]
  • symbol: DQM66_RS00875
  • description: sensor histidine kinase
  • length: 556
  • theoretical pI: 5.13089
  • theoretical MW: 64390.7
  • GRAVY: -0.272662

⊟Function[edit | edit source]

  • reaction:
    EC 2.7.13.3?  ExPASy
    Histidine kinase ATP + protein L-histidine = ADP + protein N-phospho-L-histidine
  • TIGRFAM:
    heavy metal sensor kinase (TIGR01386; EC 2.7.13.3; HMM-score: 21.4)
    and 3 more
    Cellular processes Cellular processes Sporulation and germination anti-sigma F factor (TIGR01925; EC 2.7.11.1; HMM-score: 15.4)
    Signal transduction Regulatory functions Protein interactions anti-sigma F factor (TIGR01925; EC 2.7.11.1; HMM-score: 15.4)
    Signal transduction Signal transduction Two-component systems phosphate regulon sensor kinase PhoR (TIGR02966; EC 2.7.3.-; HMM-score: 15)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    no clan defined His_kinase; Histidine kinase (PF06580; HMM-score: 74.4)
    and 6 more
    His_Kinase_A (CL0025) HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (PF02518; HMM-score: 27.3)
    no clan defined CdiI_2; CdiI immunity protein (PF18593; HMM-score: 16.8)
    His_Kinase_A (CL0025) HATPase_c_3; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (PF13589; HMM-score: 14.2)
    HAMP (CL0681) HAMP; HAMP domain (PF00672; HMM-score: 13.2)
    GlnB-like (CL0089) CutA1; CutA1 divalent ion tolerance protein (PF03091; HMM-score: 11.5)
    no clan defined DUF1003; Protein of unknown function (DUF1003) (PF06210; HMM-score: 8.4)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.04
    • Cytoplasmic Membrane Score: 9.96
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 2
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 0.9989
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0011
  • SignalP: Signal peptide SP(Sec/SPI) length 39 aa
    • SP(Sec/SPI): 0.536633
    • TAT(Tat/SPI): 0.008916
    • LIPO(Sec/SPII): 0.018141
    • Cleavage Site: CS pos: 39-40. SYA-DW. Pr: 0.4140
  • predicted transmembrane helices (TMHMM): 2

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000800583 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKNWRQNRMKQFWLHTLLRTYSSVMIIIIASFAILLSYADWDSREKEAQRVAQRVTARTVSEIEYYHRESTQIAQALVENQARIEGIYKYFSLSMPDYFYWQLERKASPYISVSLYENVDDLYVRNDFVTGVAIAFQDYKEVYVSTKDKRSGEKIRAEDFKPAGNSFAIPVSDPVSDQDLGVIYISLDPAVLYHAIDNTRGHTPMAVTVTSPFDTEIFHIGETVDRESENWLVGLTSHGYQVQVAVPKNFVLQGTVTSSALIVGLSLLFIVILYLTLRQTFANYQKQVVDLVESIQVIAQGEEGRRIDISEKDQELLLIAETTNDMLDRLEKNIHDIYQLELSQKDANMRALQAQINPHFMYNTLEFLRMYAVMQSQDELADIIYEFSSLLRNNISDERETLLKQELEFCRKYSYLCMVRYPKSIAYGFKIDPELENMKIPKFTLQPLVENYFAHGVDHRRTDNVISIKALKQDGFVEILVVDNGRGMSAEKLANIREKLSQKYFEHQASYSDQRQSIGIVNVHERFVLYFGDRYAITIESAEQAGVQYRITIQDE

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Patrick Rosendahl Andreassen, Claudia Trappetti, Vikrant Minhas, Flemming Damgaard Nielsen, Kevin Pakula, James C Paton, Mikkel Girke Jørgensen
Host-glycan metabolism is regulated by a species-conserved two-component system in Streptococcus pneumoniae.
PLoS Pathog: 2020, 16(3);e1008332
[PubMed:32130269] [WorldCat.org] [DOI] (I e)

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