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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 12-FEB-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae NCTC7466
  • locus tag: DQM66_RS02440 [old locus tag: NCTC7466_00464 ]
  • pan locus tag?: PNEUPAN000272000
  • symbol: DQM66_RS02440
  • pan gene symbol?: hsdS
  • synonym:
  • product: restriction endonuclease subunit S

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: DQM66_RS02440 [old locus tag: NCTC7466_00464 ]
  • symbol: DQM66_RS02440
  • product: restriction endonuclease subunit S
  • replicon: chromosome
  • strand: -
  • coordinates: 461322..462890
  • length: 1569
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_LS483374 (461322..462890) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    ATGACACCAGAACAACTTAAAGCAAGTATTCTCCAAAGAGCGATGGAAGGGAAATTAGTG
    CCGCAAAATCCCAATGACGAACCTGCAAGTGAATTATTAAAGAGAATTAAAGCTGAAAAA
    GAAAAACTTATCAGTGAAGGAAAAATCAAACGAGATAAAAAGGAAACTGAGATATTTCGT
    GGTGATGATGGGAAACATTATGGGAAGTTTGCTGATGGAAGTACTCAAGAAATTGATGTT
    CCTTATGATATTCCTGATACTTGGGAGTGGGTGAGGTTTTCTACATTGGTTGAAATTGTC
    AGAGGTGGCTCTCCACGACCAATCAAAGATTATCTTACTTCTGAAGTAGATGGAATAAAT
    TGGATAAAAATAGGTGATACTGAAAAGGGTGAAAAGTATATAAATAATGTTAAAGAAAAA
    ATCAAAAAATCAGGGCTTAACAAAACTAGATTTGTAAAAAAAGGTACATTTTTGTTAACT
    AATTCTATGAGTTTTGGTAGACCTTATATTTTGAATGTTGATGGTGCAATACACGATGGA
    TGGTTGGCTATTTCGAACTATGAAAACTCATTAAATAAAGATTACCTATTCTATATTCTT
    TCATCAAATGTAGTTTATTCTCAATTTCTATCTCTAATTAGTGGAGCTGTTGTGAAAAAC
    TTGAATAGTGATAAAGTTGCTTCTATTCTTATCCCTCTCCCCCCACTATCCGAACAACAA
    CGCATAATAGAAGCAATCGAATCAGCTTTAGAAAAAGTAGATGAATATGCTGAAAGTTAT
    AATAGACTAGAACAGCTAGATAAAGAATTTCCAGATAAACTAAAAAAATCTATTCTTCAA
    TATGCTATGCAAGGAAAATTAGTTGAACAAGACCCAAATGATGAATCAGTCGAAGTTTTA
    CTTGAAAAAATACGAGCAGAAAAACAAAAACTATTTGAAGAAGGCAAGATTAAAAAGAAA
    GATTTGGACATTTCTATTGTTTCCCAAGGAGATGATAACTCTTATTATGAGGAAGTACCT
    TGTGAAATACCAGAAAGTTGGGAATGGGTGAGGTTAAACGATATAACCTCCTACATTCAA
    AGAGGGAAGTCTCCAAAATATTCAAATATTCCTATATACCCTGTGATTGCTCAGAAATGT
    AATCAATGGTCTGGCTTTTCTATTGACTTAGCAAGATTTATTGATCCCGAAACAGTTCAT
    AGTTACCAGAAAGAAAGATTACTAAGGGATGGTGATTTAATGTGGAATTCAACAGGTCTA
    GGTACGTTAGGACGATTAGCTATTTACCATGAAAATAAAAATCCTTATGCCTGGGCTGTT
    GCAGATAGCCATGTTACAGTTATAAGAGTCTTATCGGGGGTTATTAATTGCCATTTCATC
    TATAATTTTCTTTCCTCTCCTATTGTTCAGTCAGTTATTGAAGAAAAAGCGTCGGGTAGT
    ACAAAACAAAAAGAATTATTAACGAAAACTATAAAAGAATATTTAATCCCCCTCCCACCC
    CTTCCTGAACAATCCAGAATCGTTGATAAAATCGAACAATTTTTCGCCCATATTGACGCA
    CTAATTTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1569

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: DQM66_RS02440 [old locus tag: NCTC7466_00464 ]
  • symbol: DQM66_RS02440
  • description: restriction endonuclease subunit S
  • length: 522
  • theoretical pI: 5.64252
  • theoretical MW: 59632.6
  • GRAVY: -0.462835

⊟Function[edit | edit source]

  • TIGRFAM:
    putative Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase, subunit C (TIGR01827; HMM-score: 15.9)
  • TheSEED: data available for D39, Hungary19A-6
  • PFAM:
    TRD (CL0477) Methylase_S; Type I restriction modification DNA specificity domain (PF01420; HMM-score: 110.4)
    and 3 more
    no clan defined DUF6291; Family of unknown function (DUF6291) (PF19808; HMM-score: 12.7)
    TIM_barrel (CL0036) NanE; Putative N-acetylmannosamine-6-phosphate epimerase (PF04131; HMM-score: 11.7)
    NOG1_N (CL0669) DUF4168; Domain of unknown function (DUF4168) (PF13767; HMM-score: 9.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9251
    • Cytoplasmic Membrane Score: 0.0092
    • Cell wall & surface Score: 0.0002
    • Extracellular Score: 0.0655
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.005342
    • TAT(Tat/SPI): 0.000647
    • LIPO(Sec/SPII): 0.001234
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000187233 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MTPEQLKASILQRAMEGKLVPQNPNDEPASELLKRIKAEKEKLISEGKIKRDKKETEIFRGDDGKHYGKFADGSTQEIDVPYDIPDTWEWVRFSTLVEIVRGGSPRPIKDYLTSEVDGINWIKIGDTEKGEKYINNVKEKIKKSGLNKTRFVKKGTFLLTNSMSFGRPYILNVDGAIHDGWLAISNYENSLNKDYLFYILSSNVVYSQFLSLISGAVVKNLNSDKVASILIPLPPLSEQQRIIEAIESALEKVDEYAESYNRLEQLDKEFPDKLKKSILQYAMQGKLVEQDPNDESVEVLLEKIRAEKQKLFEEGKIKKKDLDISIVSQGDDNSYYEEVPCEIPESWEWVRLNDITSYIQRGKSPKYSNIPIYPVIAQKCNQWSGFSIDLARFIDPETVHSYQKERLLRDGDLMWNSTGLGTLGRLAIYHENKNPYAWAVADSHVTVIRVLSGVINCHFIYNFLSSPIVQSVIEEKASGSTKQKELLTKTIKEYLIPLPPLPEQSRIVDKIEQFFAHIDALI

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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