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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 12-FEB-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae NCTC7466
  • locus tag: DQM66_RS06550 [old locus tag: NCTC7466_01263 ]
  • pan locus tag?: PNEUPAN002669000
  • symbol: DQM66_RS06550
  • pan gene symbol?: gabR
  • synonym:
  • product: PLP-dependent aminotransferase family protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: DQM66_RS06550 [old locus tag: NCTC7466_01263 ]
  • symbol: DQM66_RS06550
  • product: PLP-dependent aminotransferase family protein
  • replicon: chromosome
  • strand: +
  • coordinates: 1257313..1258584
  • length: 1272
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_LS483374 (1257313..1258584) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1225 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    ATGAAGAAACAAAGCAAGTACAAAGAGGTCGTTTCCTATCTGAAAAATGGTATCGAGTCT
    GAACGATTTCCGACGGGTAGTCGCCTGCCTTCTATCCGTCAACTGAGCCTTGACTTTCAC
    TGCAGCAAGGACACCATTCAACGAGCCCTGCTGGAATTACGGCACGAACAATACCTCTAT
    GCCAAGCCTCAGAGTGGCTACTATGTATTAGAACAAGGGCAACATCAAGACCTAGAAATC
    GAGGTTACCGACGAACATGCCAGTGCCTATGACGATTTCCGACTCTGTGTCAATGAAACC
    TTGATTGGACGAGAAAACTACCTCTTCAACTACTATGACAATCAAGAAGGATTAGAAGAC
    CTAAGACAGTCCATTCACAAACTCCTATTTGAGCAAGCTCTCTACTGCAAGGCTAACCAA
    CTAGTACTGACTTCTGGAACCCAACAAGCCTTGTTTATCCTCTCTCAAATATCCTTTCCT
    AGACAAGCCAAGGAAATCTTGGTGGAACAGCCAACCTACCATCGGATGAATCGCCTCTTG
    ATTGCACAGGGGCTGGACTATCAAACGATTGAACGAGGCATTGATGGGATTGACTTGGAG
    GAGCTGGAAGGCCACTTCAAAACAGGAAAAATTAAATTTTTCTACACCATTCCTAGATTT
    CACTATCCTCTGGGACATTCCTATTCTGAGCAAGACAAACGATCTATTCTTAACTTAGCT
    GCCAAGTATGATGTCTATATCGTAGAGGACGATTATCTGGGTGATTTGGACTCCAAGAAG
    GGCCAAACCTTCCACTATCTTGATACAGAGGAGCATGTCATTTATATCAAGTCCTTCTCG
    ACCAGCCTTTTTCCTGCCCTTCGTATTACAGCACTCATTCTTCCAAATGCTATCAAAGAA
    GCATTTGTGGCCTACAAAAATATCCTAGACTACGACAGCAACCTCATTATGCAAAAGGCC
    CTGTCACTCTATATTGACAGTCAATTGTTTGAAAAAAATCGTTTGGCTCGCTTGACCAAT
    CATGAATCTTACCAAAAACAAATCGAGGAAAGGATAACTAAAACACCTTGTCCCCTTCCT
    CATTATCCCCTACACGATGGTTTATTGCTAGACCTGAGACAGTATCCTAAAATCGCCAGT
    CTCAAACACAGTCAACTGGGCTTGGACTTCTTTGAAGAGGCCTATTTAAGCACCTGTCCT
    TATCAATTTGCCAAGGTGTCCCTAGACAATCTGGAAAATGTTTTAAACTATTTAAAAGCA
    GAATTGGAATGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1272

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: DQM66_RS06550 [old locus tag: NCTC7466_01263 ]
  • symbol: DQM66_RS06550
  • description: PLP-dependent aminotransferase family protein
  • length: 423
  • theoretical pI: 5.99982
  • theoretical MW: 49407.8
  • GRAVY: -0.44539

⊟Function[edit | edit source]

  • TIGRFAM:
    enduracididine biosynthesis enzyme MppQ (TIGR04461; EC 2.-.-.-; HMM-score: 67)
    and 12 more
    Metabolism Energy metabolism Amino acids and amines histidine utilization repressor (TIGR02018; HMM-score: 34.4)
    Signal transduction Regulatory functions DNA interactions histidine utilization repressor (TIGR02018; HMM-score: 34.4)
    beta-methylarginine biosynthesis bifunctional aminotransferase (TIGR04544; EC 2.6.-.-; HMM-score: 33)
    tyrosine/nicotianamine family aminotransferase (TIGR01265; HMM-score: 32.3)
    Signal transduction Regulatory functions DNA interactions trehalose operon repressor (TIGR02404; HMM-score: 31.1)
    Cellular processes Cellular processes Biosynthesis of natural products capreomycidine synthase (TIGR03947; HMM-score: 28.5)
    putative C-S lyase (TIGR04350; EC 4.4.-.-; HMM-score: 28)
    Metabolism Energy metabolism Amino acids and amines tyrosine aminotransferase (TIGR01264; EC 2.6.1.5; HMM-score: 23)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Heme, porphyrin, and cobalamin threonine-phosphate decarboxylase (TIGR01140; EC 4.1.1.81; HMM-score: 18.4)
    Signal transduction Regulatory functions DNA interactions phosphonate utilization transcriptional regulator PhnR (TIGR03337; HMM-score: 18.2)
    Metabolism Transport and binding proteins Anions phosphonate metabolism transcriptional regulator PhnF (TIGR02325; HMM-score: 17.2)
    Signal transduction Regulatory functions DNA interactions phosphonate metabolism transcriptional regulator PhnF (TIGR02325; HMM-score: 17.2)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    PLP_aminotran (CL0061) Aminotran_1_2; Aminotransferase class I and II (PF00155; HMM-score: 49.4)
    HTH (CL0123) GntR; Bacterial regulatory proteins, gntR family (PF00392; HMM-score: 45)
    and 3 more
    PLP_aminotran (CL0061) Asp_aminotransf; Aspartate amino-transferase (PF12897; HMM-score: 19.7)
    HTH (CL0123) HTH_41; Helix-turn-helix domain (PF14502; HMM-score: 17.9)
    HTH_36; Helix-turn-helix domain (PF13730; HMM-score: 12.1)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.8873
    • Cytoplasmic Membrane Score: 0.0603
    • Cell wall & surface Score: 0.0042
    • Extracellular Score: 0.0483
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.011273
    • TAT(Tat/SPI): 0.000835
    • LIPO(Sec/SPII): 0.001483
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000744821 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKKQSKYKEVVSYLKNGIESERFPTGSRLPSIRQLSLDFHCSKDTIQRALLELRHEQYLYAKPQSGYYVLEQGQHQDLEIEVTDEHASAYDDFRLCVNETLIGRENYLFNYYDNQEGLEDLRQSIHKLLFEQALYCKANQLVLTSGTQQALFILSQISFPRQAKEILVEQPTYHRMNRLLIAQGLDYQTIERGIDGIDLEELEGHFKTGKIKFFYTIPRFHYPLGHSYSEQDKRSILNLAAKYDVYIVEDDYLGDLDSKKGQTFHYLDTEEHVIYIKSFSTSLFPALRITALILPNAIKEAFVAYKNILDYDSNLIMQKALSLYIDSQLFEKNRLARLTNHESYQKQIEERITKTPCPLPHYPLHDGLLLDLRQYPKIASLKHSQLGLDFFEEAYLSTCPYQFAKVSLDNLENVLNYLKAELE

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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