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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 30-NOV-2024

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae EF3030
  • locus tag: EF3030_RS00860 [old locus tag: EF3030_00860 ]
  • pan locus tag?: PNEUPAN000871000
  • symbol: EF3030_RS00860
  • pan gene symbol?: yesN
  • synonym:
  • product: response regulator transcription factor

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: EF3030_RS00860 [old locus tag: EF3030_00860 ]
  • symbol: EF3030_RS00860
  • product: response regulator transcription factor
  • replicon: chromosome
  • strand: +
  • coordinates: 158879..160165
  • length: 1287
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_CP035897 (158879..160165) NCBI
  • BioCyc: EF3030_RS00860 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0158 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    ATGTATAAAGTATTATTAGTAGATGATGAGTACATGGTGACAGAAGGTCTGAAGCGTTTG
    ATTCCCTTTGATAAGTGGGATATGGAGGTCGTCGCAACAGCCAGTCATGCCGATGAAGCT
    CTAGAATATGTTCAGGAAAATCCTGTCGATGTCATCATTTCCGATGTCAATATGCCAGAC
    AAAACAGGGCTTGATATGATTCGGGAGATGAAAGAGATCTTACCAGATGCTGCCTATATC
    CTGCTCTCAGGTTATCAGGAGTTTGATTATGTAAAAAGAGCAATGAACCTTAGTGTGGTG
    GACTATTTGGTCAAACCTGTTGATAAGGTAGAGCTGGGAAATCTGCTGGAGAAGATTGCA
    GGTCAGCTCGGCGAGAGAGGGAAGAAAAGTCAGACTCTTAGTCAAGAATTAGACGAGGCT
    GGATTTGTTAGTTATTTAGGGGATAAGGAGAATTGGTGGATAGGTCTATCCAAGGAAAAA
    CAAGGTTCCTTCACCATTCCCTACTATGTCTTGGGTCAAGCCTGGCAGATTTTCATTTCT
    GACCAACCCCTAGATGGTTTAGTCGTTACACCTTTTGAAGCTCCTTATCAAGAACATTTT
    GAACGCTGGAAGCTGAATGCTGAGAAAACCCTCTTTTACGGTTCTGTAAATCTGCAGCAG
    TCTGAGAGTCTCTTTGCCTATTACGAACCGATTTATAGGGTTATCATTCAGGGAAATCTC
    AATCAAATCGTAGAAGAGTTAAATCTCTTGGAGAAGGTAGTTCTTGAAAATACGCCGCGA
    ATTCCGATTACTAAACAGCTTTTTATCCAGTTTGTCATGGATGTCTTCCATTTATTTGAA
    CATCTCAAAGCTGATGATATGACGGACATTGTCAAAACCATTCATGCTATTCAATCCTTC
    GATGAATTGGTTTCTTATATCAAGGAAACTCTGATCAGCTTTTTCGGTCAATACCGTATG
    AATGAAAATGTGGTCAGTGTGCTGGAAGTCATTGGTCGTGATTACCAAAAAGAGCTTTCC
    CTCAAGGATATCAGTAAGGCCCTCTTTATCAATCCTGTCTATCTAGGGCAGTTGATTAAG
    CGTGAAACCGATTCGACCTTTGCAGAGTTACTAAACAAACAACGTATTAAGGCTGCCCAG
    CAGCTCTTGCTTTCAACCAGTGACAGTATCGAAGATATTTGTTATGCTGTTGGTTACAGT
    AACCTTGGATATTTCTATAAAGTTTTCCGAAAATTGTGCGGAAAATCGCCAAAAGCCTAC
    CGAAAACAGGTAGAAACTATACTATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1287

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: EF3030_RS00860 [old locus tag: EF3030_00860 ]
  • symbol: EF3030_RS00860
  • description: response regulator transcription factor
  • length: 428
  • theoretical pI: 4.60701
  • theoretical MW: 49380.4
  • GRAVY: -0.13785

⊟Function[edit | edit source]

  • TIGRFAM:
    YSIRK-targeted surface antigen transcriptional regulator (TIGR04094; HMM-score: 56.2)
    Metabolism Central intermediary metabolism Nitrogen metabolism nitrogen regulation protein NR(I) (TIGR01818; HMM-score: 53.2)
    Signal transduction Regulatory functions DNA interactions nitrogen regulation protein NR(I) (TIGR01818; HMM-score: 53.2)
    Signal transduction Signal transduction Two-component systems nitrogen regulation protein NR(I) (TIGR01818; HMM-score: 53.2)
    and 8 more
    4-hydroxyphenylacetate catabolism regulatory protein HpaA (TIGR02297; HMM-score: 44.9)
    Cellular processes Cellular processes Sporulation and germination sporulation transcription factor Spo0A (TIGR02875; HMM-score: 44.5)
    Signal transduction Regulatory functions DNA interactions phosphate regulon transcriptional regulatory protein PhoB (TIGR02154; HMM-score: 35)
    Signal transduction Signal transduction Two-component systems phosphate regulon transcriptional regulatory protein PhoB (TIGR02154; HMM-score: 35)
    Signal transduction Regulatory functions DNA interactions heavy metal response regulator (TIGR01387; HMM-score: 31.6)
    Signal transduction Signal transduction Two-component systems TMAO reductase sytem sensor TorS (TIGR02956; EC 2.7.13.3; HMM-score: 27.1)
    Signal transduction Regulatory functions DNA interactions PEP-CTERM-box response regulator transcription factor (TIGR02915; HMM-score: 26.5)
    Signal transduction Regulatory functions DNA interactions staphylococcal accessory regulator family (TIGR01889; HMM-score: 13.1)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    CheY (CL0304) Response_reg; Response regulator receiver domain (PF00072; HMM-score: 86.9)
    HTH (CL0123) HTH_18; Helix-turn-helix domain (PF12833; HMM-score: 70.9)
    and 4 more
    HTH_AraC; Bacterial regulatory helix-turn-helix proteins, AraC family (PF00165; HMM-score: 51.6)
    no clan defined BAF; Barrier to autointegration factor (PF02961; HMM-score: 13.5)
    RAC_head; Ribosome-associated complex head domain (PF16717; HMM-score: 13.2)
    P16-Arc; ARP2/3 complex 16 kDa subunit (p16-Arc) (PF04699; HMM-score: 12.2)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.95
    • Cytoplasmic Membrane Score: 0.05
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9271
    • Cytoplasmic Membrane Score: 0.0692
    • Cell wall & surface Score: 0.0019
    • Extracellular Score: 0.0019
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.002909
    • TAT(Tat/SPI): 0.000109
    • LIPO(Sec/SPII): 0.000275
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000278864 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MYKVLLVDDEYMVTEGLKRLIPFDKWDMEVVATASHADEALEYVQENPVDVIISDVNMPDKTGLDMIREMKEILPDAAYILLSGYQEFDYVKRAMNLSVVDYLVKPVDKVELGNLLEKIAGQLGERGKKSQTLSQELDEAGFVSYLGDKENWWIGLSKEKQGSFTIPYYVLGQAWQIFISDQPLDGLVVTPFEAPYQEHFERWKLNAEKTLFYGSVNLQQSESLFAYYEPIYRVIIQGNLNQIVEELNLLEKVVLENTPRIPITKQLFIQFVMDVFHLFEHLKADDMTDIVKTIHAIQSFDELVSYIKETLISFFGQYRMNENVVSVLEVIGRDYQKELSLKDISKALFINPVYLGQLIKRETDSTFAELLNKQRIKAAQQLLLSTSDSIEDICYAVGYSNLGYFYKVFRKLCGKSPKAYRKQVETIL

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Patrick Rosendahl Andreassen, Claudia Trappetti, Vikrant Minhas, Flemming Damgaard Nielsen, Kevin Pakula, James C Paton, Mikkel Girke Jørgensen
Host-glycan metabolism is regulated by a species-conserved two-component system in Streptococcus pneumoniae.
PLoS Pathog: 2020, 16(3);e1008332
[PubMed:32130269] [WorldCat.org] [DOI] (I e)

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