PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BM6001

serotype 19F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7465

serotype 1

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 30-NOV-2024

⊟Summary

• organism: Streptococcus pneumoniae EF3030
• locus tag: EF3030_RS10040 [old locus tag: EF3030_10040 ]
• pan locus tag^?: PNEUPAN003685000
• symbol: comGC
• pan gene symbol^?: comGC
• synonym:
• product: comG operon protein ComGC

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: EF3030_RS10040 [old locus tag: EF3030_10040 ]
• symbol: comGC
• product: comG operon protein ComGC
• replicon: chromosome
• strand: -
• coordinates: 1890439..1890765
• length: 327
• essential: unknown

⊟Accession numbers

• Location: NZ_CP035897 (1890439..1890765) NCBI
• BioCyc: EF3030_RS10040 BioCyc
• MicrobesOnline:
• PneumoBrowse for strain D39V: SPV_1861 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  
  ATGAAAAAAATGATGACATTCTTGAAAAAAGCTAAGGTTAAAGCTTTTACATTGATTGAG
  ATGTTGGTGGTCTTGCTGATTATCAGCGTGCTTTTCTTGCTCTTTGTACCTAATCTGACC
  AAGCAAAAAGAGGCAGTCAATGACAAAGGAAAAGCAGCTGTTGTTAAGGTGGTGGAAAGC
  CAGGCAGAACTTTATAGCTTGGAAAAGAATGAAGATGCTAGCCTAAGCAAGTTACAAGCA
  GATGGGCGAATCACGGAAGAACAGGCTAAAGCTTATAAAGAATACCATGATAAAAATGGA
  GTAGCAAATCGTAAAGTCAATGATTAA
  60
  120
  180
  240
  300
  327
  

⊟Protein

⊟General

• locus tag: EF3030_RS10040 [old locus tag: EF3030_10040 ]
• symbol: ComGC
• description: comG operon protein ComGC
• length: 108
• theoretical pI: 10.0568
• theoretical MW: 12187.3
• GRAVY: -0.181481

⊟Function

• TIGRFAM:
  Cellular processes Cellular processes Pathogenesis type II secretion system protein G (TIGR01710; HMM-score: 34.3)
  Genetic information processing Protein fate Protein and peptide secretion and trafficking type II secretion system protein G (TIGR01710; HMM-score: 34.3)
  and 8 more
  Cell structure Cell envelope Surface structures prepilin-type N-terminal cleavage/methylation domain (TIGR02532; HMM-score: 24.4)
  Genetic information processing Protein fate Protein and peptide secretion and trafficking prepilin-type N-terminal cleavage/methylation domain (TIGR02532; HMM-score: 24.4)
  Cell structure Cell envelope Surface structures Verru_Chthon cassette protein D (TIGR02596; HMM-score: 21.2)
  Cell structure Cell envelope Surface structures Verru_Chthon cassette protein C (TIGR02599; HMM-score: 17.8)
  Cellular processes Cellular processes Pathogenesis type II secretion system protein H (TIGR01708; HMM-score: 17.5)
  Genetic information processing Protein fate Protein and peptide secretion and trafficking type II secretion system protein H (TIGR01708; HMM-score: 17.5)
  type II secretion system protein I (TIGR01707; HMM-score: 15.3)
  TIGR03943 family protein (TIGR03943; HMM-score: 11.9)
• TheSEED: data available for D39, Hungary19A-6, TIGR4
• PFAM:
  no clan defined N_methyl; Prokaryotic N-terminal methylation motif (PF07963; HMM-score: 28.1)
  and 5 more
  NusG_II; NusG domain II (PF07009; HMM-score: 15.4)
  DUF4330; Domain of unknown function (DUF4330) (PF14221; HMM-score: 15.4)
  DUF1980; Domain of unknown function (DUF1980) (PF09323; HMM-score: 14.4)
  SecD-TM1; SecD export protein N-terminal TM region (PF13721; HMM-score: 14.2)
  Omega_toxin (CL0083) Conotoxin; Conotoxin (PF02950; HMM-score: 11.1)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: unknown (no significant prediction)
  • Cytoplasmic Score: 2.5
  • Cytoplasmic Membrane Score: 2.5
  • Cellwall Score: 2.5
  • Extracellular Score: 2.5
  • Internal Helix: 1
• DeepLocPro: Cytoplasmic Membrane
  • Cytoplasmic Score: 0.0142
  • Cytoplasmic Membrane Score: 0.8276
  • Cell wall & surface Score: 0.0295
  • Extracellular Score: 0.1287
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.109535
  • TAT(Tat/SPI): 0.000593
  • LIPO(Sec/SPII): 0.005645
• predicted transmembrane helices (TMHMM): 1

⊟Accession numbers

• GI:
• RefSeq: WP_000738623 NCBI
• UniProt:

⊟Protein sequence

• MKKMMTFLKKAKVKAFTLIEMLVVLLIISVLFLLFVPNLTKQKEAVNDKGKAAVVKVVESQAELYSLEKNEDASLSKLQADGRITEEQAKAYKEYHDKNGVANRKVND

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• data available for D39, D39V

⊟Expression data

• PneumoExpress for strain D39V: SPV_1861 PneumoExpress

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You can add further information about the gene and protein here. [edit]

⊟Literature

⊟References

⊟Relevant publications