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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 12-FEB-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae ATCC 49619
  • locus tag: EL263_RS02690 [old locus tag: SPAT_0497 ]
  • pan locus tag?: PNEUPAN001393000
  • symbol: EL263_RS02690
  • pan gene symbol?: blpR
  • synonym:
  • product: response regulator transcription factor

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: EL263_RS02690 [old locus tag: SPAT_0497 ]
  • symbol: EL263_RS02690
  • product: response regulator transcription factor
  • replicon: chromosome
  • strand: +
  • coordinates: 497284..498021
  • length: 738
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_AP018938 (497284..498021) NCBI
  • BioCyc: EL263_RS02690 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0468 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAGACTAGGATTGAAACGACGATT
    GAGAAACTCTTGAAAGAACATCAGATCGTTCCCAGCTCTTTTGAAGTTTTTGGTAAGCCA
    GACCAGCTGCTGGCAGAGGTGCATGAGAAGGGAGCTCATCAGCTATTCTTTTTGGACATT
    GAGATTCGAAACGAGGAGATGAAGGGTCTGGAAGTGGCTAGAAAGATCCGGGATCGGGAT
    CCTTATGCCTTGATAGTCTTTGTGACGACTCACTCGGAGTTTATGCCTCTGTCCTTTCGC
    TACCAAGTGTCTGCTCTAGACTACATTGATAAGGCCTTGTCAGCAGAGGAGTTTGAATCT
    CGGATCGAGACAGCCCTTCTCTATGCCAATAGTCAAGATAGTAAAAGTTTGGCGGAAGAT
    TGCTTTTACTTTAAATCAAAATTTGCCCAATTCCAGTATCCTTTTAAAGAGGTTTATTAT
    CTTGAAACGTCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAA
    TTTACAGCGAGTTTAGAGGAGGTTTTCAAGCAGGAGCCCCGTCTCTTGCAGTGCCACCGC
    TCTTTTCTCATCAATCCTGCCAATGTAGTTCGTTTGGATAAGAAAGAAAAACTTCTTTAC
    TTTCCCAATGGTGGAAGCTGTATGATAGCGCGTTATAAGGTCAGGGAAGTGTCTGAAGCT
    ATCAATAACTTACATTGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    738

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: EL263_RS02690 [old locus tag: SPAT_0497 ]
  • symbol: EL263_RS02690
  • description: response regulator transcription factor
  • length: 245
  • theoretical pI: 6.17855
  • theoretical MW: 28828.8
  • GRAVY: -0.351429

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Central intermediary metabolism Nitrogen metabolism nitrogen regulation protein NR(I) (TIGR01818; HMM-score: 25.2)
    Signal transduction Regulatory functions DNA interactions nitrogen regulation protein NR(I) (TIGR01818; HMM-score: 25.2)
    Signal transduction Signal transduction Two-component systems nitrogen regulation protein NR(I) (TIGR01818; HMM-score: 25.2)
    and 4 more
    proteobacterial dedicated sortase system response regulator (TIGR03787; HMM-score: 19.7)
    Signal transduction Regulatory functions DNA interactions phosphate regulon transcriptional regulatory protein PhoB (TIGR02154; HMM-score: 17.3)
    Signal transduction Signal transduction Two-component systems phosphate regulon transcriptional regulatory protein PhoB (TIGR02154; HMM-score: 17.3)
    Signal transduction Regulatory functions DNA interactions heavy metal response regulator (TIGR01387; HMM-score: 13.7)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    Tudor (CL0049) LytTR; LytTr DNA-binding domain (PF04397; HMM-score: 62.8)
    and 3 more
    CheY (CL0304) Response_reg; Response regulator receiver domain (PF00072; HMM-score: 43.3)
    Ubiquitin (CL0072) RBD; Raf-like Ras-binding domain (PF02196; HMM-score: 13.2)
    no clan defined OmdA; Bacteriocin-protection, YdeI or OmpD-Associated (PF13376; HMM-score: 12.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9778
    • Cytoplasmic Membrane Score: 0.0107
    • Cell wall & surface Score: 0.0006
    • Extracellular Score: 0.0109
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.001475
    • TAT(Tat/SPI): 0.000106
    • LIPO(Sec/SPII): 0.000189
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_050221200 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MRIFVLEDDFSQQTRIETTIEKLLKEHQIVPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRDPYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYYLETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVRLDKKEKLLYFPNGGSCMIARYKVREVSEAINNLH

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

A de Saizieu, C Gardès, N Flint, C Wagner, M Kamber, T J Mitchell, W Keck, K E Amrein, R Lange
Microarray-based identification of a novel Streptococcus pneumoniae regulon controlled by an autoinduced peptide.
J Bacteriol: 2000, 182(17);4696-703
[PubMed:10940007] [WorldCat.org] [DOI] (P p)Wei-Yun Wholey, Travis J Kochan, David N Storck, Suzanne Dawid
Coordinated Bacteriocin Expression and Competence in Streptococcus pneumoniae Contributes to Genetic Adaptation through Neighbor Predation.
PLoS Pathog: 2016, 12(2);e1005413
[PubMed:26840124] [WorldCat.org] [DOI] (I e)Morten Kjos, Eric Miller, Jelle Slager, Frank B Lake, Oliver Gericke, Ian S Roberts, Daniel E Rozen, Jan-Willem Veening
Expression of Streptococcus pneumoniae Bacteriocins Is Induced by Antibiotics via Regulatory Interplay with the Competence System.
PLoS Pathog: 2016, 12(2);e1005422
[PubMed:26840404] [WorldCat.org] [DOI] (I e)

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