PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BM6001

serotype 19F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7465

serotype 1

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 12-FEB-2025

⊟Summary

• organism: Streptococcus pneumoniae ATCC 49619
• locus tag: EL263_RS04485 [old locus tag: SPAT_0840 ]
• pan locus tag^?: PNEUPAN001877000
• symbol: EL263_RS04485
• pan gene symbol^?: —
• synonym:
• product: alpha/beta hydrolase

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: EL263_RS04485 [old locus tag: SPAT_0840 ]
• symbol: EL263_RS04485
• product: alpha/beta hydrolase
• replicon: chromosome
• strand: +
• coordinates: 841923..842621
• length: 699
• essential: unknown

⊟Accession numbers

• Location: NZ_AP018938 (841923..842621) NCBI
• BioCyc: EL263_RS04485 BioCyc
• MicrobesOnline:
• PneumoBrowse for strain D39V: SPV_0796 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
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  541
  601
  661
  
  ATGAAAAAATATTTTATTGGCGGTTTGGGAAGCAATGCCTATCATAGCAAGGATTTTTTT
  CAAGAACTAGATTCGCAGGTCTATTTTCTAAATCCATATGAAAAGCATCTTCGAGATGAA
  ACAGAATTGAAATCATGGTTTAAAAATGAGATTGTAGAGGAAGAATCTATCTGTCTGATA
  GGCCATTCTCTTGGAGGAGATTTAGCTCGTTATCTCGCATCGGAATTTGAAGAAGTAAAA
  AAACTGATTCTTTTGGATGGTGGCTATCTAGATTTAGATAAGATTTTACCTTTGGATACA
  GAGTTAGAGGAAACTAAAAATTATATCAAATCTCAAATTGTTTTGGACTTAGCTCTTCTT
  ATTTCTAAAGAAAAATCTGAAGTAAAGCATTGGTCAGAAAATATGGAGAAAGCTGTAAGA
  CAGTCTTATCACTGGAATGTTGAGTATAATAGATATGAGTTGGCTATAAATTATGAAAAT
  ATAGAAGCGATACTCCGCCTACGGAGAAAAATACAAGCTTTTAAGAGAGAAGTGGGAGAT
  ACCTTGTTTATTAGTCCTCGCTATCCTAATGAAGCTACATGGAGAGAGGAAGCCCTATTT
  GATACTATTTTTTTAGAAAACTTTGGCCATGAGCTTTATACTCAAGCACCTAAAGAAATC
  GCTAGTCTAATGAATGAGTGGCTCGCTTATTTTCTATGA
  60
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  699
  

⊟Protein

⊟General

• locus tag: EL263_RS04485 [old locus tag: SPAT_0840 ]
• symbol: EL263_RS04485
• description: alpha/beta hydrolase
• length: 232
• theoretical pI: 4.73599
• theoretical MW: 27484
• GRAVY: -0.444397

⊟Function

• TIGRFAM:
  Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Menaquinone and ubiquinone 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (TIGR03695; EC 4.2.99.20; HMM-score: 19.4)
  and 1 more
  Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Glutathione and analogs putative glutamate--cysteine ligase (TIGR02048; EC 6.3.2.2; HMM-score: 11.6)
• TheSEED: data available for D39, Hungary19A-6, TIGR4
• PFAM:
  AB_hydrolase (CL0028) Abhydrolase_1; alpha/beta hydrolase fold (PF00561; HMM-score: 22.4)
  BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal (PF08840; HMM-score: 20.8)
  Palm_thioest; Palmitoyl protein thioesterase (PF02089; HMM-score: 18.8)
  PGAP1; PGAP1-like protein (PF07819; HMM-score: 18.1)
  and 7 more
  Lipase_3; Lipase (class 3) (PF01764; HMM-score: 17.8)
  UPF0227; Uncharacterised protein family (UPF0227) (PF05728; HMM-score: 14.9)
  Abhydrolase_3; alpha/beta hydrolase fold (PF07859; HMM-score: 13.4)
  Mbeg1-like; Mbeg1-like (PF11187; HMM-score: 13.4)
  Hydrolase_4; Serine aminopeptidase, S33 (PF12146; HMM-score: 13.3)
  DLH; Dienelactone hydrolase family (PF01738; HMM-score: 12.9)
  PAF-AH_p_II; Platelet-activating factor acetylhydrolase, isoform II (PF03403; HMM-score: 10.8)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cytoplasmic Membrane
  • Cytoplasmic Score: 1.78
  • Cytoplasmic Membrane Score: 8.16
  • Cellwall Score: 0.06
  • Extracellular Score: 0.01
  • Internal Helices: 0
• DeepLocPro: Cytoplasmic
  • Cytoplasmic Score: 0.9787
  • Cytoplasmic Membrane Score: 0.0037
  • Cell wall & surface Score: 0.0008
  • Extracellular Score: 0.0168
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.004262
  • TAT(Tat/SPI): 0.000079
  • LIPO(Sec/SPII): 0.00051
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: WP_054387406 NCBI
• UniProt:

⊟Protein sequence

• MKKYFIGGLGSNAYHSKDFFQELDSQVYFLNPYEKHLRDETELKSWFKNEIVEEESICLIGHSLGGDLARYLASEFEEVKKLILLDGGYLDLDKILPLDTELEETKNYIKSQIVLDLALLISKEKSEVKHWSENMEKAVRQSYHWNVEYNRYELAINYENIEAILRLRRKIQAFKREVGDTLFISPRYPNEATWREEALFDTIFLENFGHELYTQAPKEIASLMNEWLAYFL

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator:

⊟Transcription

• transcription start site:

⊟Expression data

• PneumoExpress for strain D39V: SPV_0796 PneumoExpress

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You can add further information about the gene and protein here. [edit]

⊟Literature

⊟References

⊟Relevant publications