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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 14-DEC-2020

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae ATCC 49619
  • locus tag: EL263_RS05435 [old locus tag: SPAT_1022 ]
  • pan locus tag?: PNEUPAN002239000
  • symbol: EL263_RS05435
  • pan gene symbol?: rex
  • synonym:
  • product: redox-sensing transcriptional repressor Rex

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: EL263_RS05435 [old locus tag: SPAT_1022 ]
  • symbol: EL263_RS05435
  • product: redox-sensing transcriptional repressor Rex
  • replicon: chromosome
  • strand: -
  • coordinates: 1015623..1016264
  • length: 642
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_AP018938 (1015623..1016264) NCBI
  • BioCyc: EL263_RS05435 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0976 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    GTGAAAGATAAACAGTTTGCTATTCCAAAAGCTACAGCAAAAAGACTCTCTCTCTACTAT
    CGAATTTTTAAGAGATTTCATGCAGAAAAGATTGAACGTGCCAACTCTAAGCAAATTGCA
    GAGGCTATCGGTATTGATTCAGCGACCGTACGTCGTGATTTTTCCTATTTTGGTGAACTT
    GGTCGTCGTGGTTTTGGCTATGATGTCAAAAAACTAATGACATTTTTTGCTGATTTGCTC
    AATGACAACTCTATTACCAATGTCATGCTGGTTGGTATTGGAAATATGGGCCATGCCCTT
    CTCCACTACCGCTTCCACGAACGTAACAAAATGAAGATTATCATGGCCTTTGACCTAGAC
    GACCATCCTGAAGTCGGTACCCAAACTCCTGACGGGATTCCCATTTACGGGATTTCTCAG
    ATCAAGGATAAAATCAAGGATGCTGATGTGAAGACTGCTATCCTAACTGTTCCCAGCGTC
    AAGTCACAAGAGGTTGCTAATCTCTTGGTTGATGCTGGTGTGAAAGGAATTCTCAGTTTT
    TCACCAGTCCATCTGCATTTACCAAAAGACGTGGTCGTTCAGTATGTCGATTTGACAAGT
    GAACTCCAAACCCTCCTCTACTTCATGCGAAAAGAGGATTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    642

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: EL263_RS05435 [old locus tag: SPAT_1022 ]
  • symbol: EL263_RS05435
  • description: redox-sensing transcriptional repressor Rex
  • length: 213
  • theoretical pI: 9.60544
  • theoretical MW: 24164.9
  • GRAVY: -0.164319

⊟Function[edit | edit source]

  • TIGRFAM:
    undecaprenyl-phosphate glucose phosphotransferase (TIGR03023; EC 2.7.8.-; HMM-score: 16)
    and 2 more
    exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase (TIGR03025; HMM-score: 12.6)
    Signal transduction Regulatory functions DNA interactions mycofactocin system transcriptional regulator (TIGR03968; HMM-score: 12)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    NADP_Rossmann (CL0063) CoA_binding; CoA binding domain (PF02629; HMM-score: 89.5)
    and 2 more
    HTH (CL0123) Put_DNA-bind_N; Putative DNA-binding protein N-terminus (PF06971; HMM-score: 62.6)
    HTH_DeoR; DeoR-like helix-turn-helix domain (PF08220; HMM-score: 14.7)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • genes regulated by Rex*, TF important in Energy metabolism: in TIGR4

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 1.78
    • Cytoplasmic Membrane Score: 8.16
    • Cellwall Score: 0.06
    • Extracellular Score: 0.01
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.005911
    • TAT(Tat/SPI): 0.0007
    • LIPO(Sec/SPII): 0.000764
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000653403 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKDKQFAIPKATAKRLSLYYRIFKRFHAEKIERANSKQIAEAIGIDSATVRRDFSYFGELGRRGFGYDVKKLMTFFADLLNDNSITNVMLVGIGNMGHALLHYRFHERNKMKIIMAFDLDDHPEVGTQTPDGIPIYGISQIKDKIKDADVKTAILTVPSVKSQEVANLLVDAGVKGILSFSPVHLHLPKDVVVQYVDLTSELQTLLYFMRKED

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Muhammad Afzal, Sulman Shafeeq, Oscar P Kuipers
NADH-Mediated Gene Expression in Streptococcus pneumoniae and Role of Rex as a Transcriptional Repressor of the Rex-Regulon.
Front Microbiol: 2018, 9;1300
[PubMed:29971050] [WorldCat.org] [DOI] (P e)

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