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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 14-DEC-2020

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae ATCC 49619
  • locus tag: EL263_RS10380 [old locus tag: SPAT_1967 ]
  • pan locus tag?: PNEUPAN003750000
  • symbol: mutS
  • pan gene symbol?: hexA
  • synonym:
  • product: DNA mismatch repair protein MutS

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: EL263_RS10380 [old locus tag: SPAT_1967 ]
  • symbol: mutS
  • product: DNA mismatch repair protein MutS
  • replicon: chromosome
  • strand: -
  • coordinates: 1916940..1919474
  • length: 2535
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_AP018938 (1916940..1919474) NCBI
  • BioCyc: EL263_RS10380 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1903 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    2281
    2341
    2401
    2461
    2521
    ATGGCGATAGAAAAGCTATCACCCGGCATGCAACAGTATGTGGATATTAAAAAGCAATAT
    CCAGATGCTTTTTTGCTCTTTCGGATGGGTGATTTTTATGAATTATTTTATGAGGATGCG
    GTCAATGCTGCGCAGATTCTGGAAATTTCCTTAACGAGTCGCAACAAGAATGCCGACAAT
    CCGATCCCTATGGCGGGTGTTCCCTATCATTCTGCCCAACAGTATATCGATGTCTTGATT
    GAGCAGGGTTATAAGGTGGCTATCGCAGAGCAGATGGAAGATCCTAAACAAGCAGTTGGG
    GTTGTTAAACGAGAGGTTGTTCAGGTCATTACGCCAGGGACAGTGGTCGATAGCAGTAAG
    CCGGACAGTCAGAATAATTTTTTGGTTTCCATAGACCGCGAAGGCAATCAATTTGGCCTA
    GCTTATATGGATTTGGTGACGGGTGACTTTTATGTGACAGGTCTTTTGGATTTCACGCTG
    GTTTGTGGGGAAATCCGTAACCTCAAGGCTCGAGAAGTGGTGTTGGGTTATGACTTGTCT
    GAGGAAGAAGAACAAATCCTCAGCCGCCAGATGAATCTGGTACTCTCTTATGAAAAAGAA
    AGCTTTGAAGACCTTCATTTATTGGATTTGCGATTGGCAACGGTGGAGCAAACGGCATCT
    AGTAAGCTGCTCCAGTATGTTCATCGGACTCAGATGAGGGAATTGAACCACCTCAAACCT
    GTTATCCGCTACGAAATTAAGGATTTCTTGCAGATGGATTATGCGACCAAGGCTAGTCTG
    GATTTGGTTGAGAATGCTCGCTCAGGTAAGAAACAAGGCAGTCTTTTCTGGCTTTTGGAT
    GAAACCAAAACGGCTATGGGGATGCGTCTCTTGCGTTCTTGGATTCATCGCCCCTTGATT
    GATAAGGAACGAATCGTCCAACGTCAAGAAGTAGTGCAGGTCTTTCTCGACCATTTCTTT
    GAGCGTAGTGACTTGACAGACAGTCTCAAGGGTGTTTATGACATTGAGCGCTTGGCTAGT
    CGTGTTTCTTTTGGCAAAACCAATCCAAAGGATCTCTTGCAGTTGGCGACTACCTTGTCT
    AGTGTGCCACGGATTCGTGCGATTTTAGAAGGGATGGAGCAACCTACTCTAGCCTATCTC
    ATCGCACAACTGGATGCAATCCCTGAGTTGGAGAGTTTGATTAGCGCAGCGATTGCTCCT
    GAAGCTCCTCATGTGATTACAGATGGGGGAATTATCCGGACTGGATTTGATGAGACTTTA
    GACAAGTATCGTTGCGTTCTCAGAGAAGGGACTAGCTGGATTGCTGAGATTGAGGCTAAG
    GAGCGAGAAAACTCTGGTATCAGCACGCTCAAGATTGACTACAATAAAAAGGATGGCTAC
    TATTTTCATGTGACCAATTCGCAACTAGGAAATGTGCCAGCCCACTTTTTCCGCAAGGCG
    ACGCTGAAAAACTCAGAACGCTTTGGAACCGAAGAATTAGCCCGTATCGAGGGAGATATG
    CTTGAGGCGCGTGAGAAGTCAGCCAACCTCGAATACGAAATATTTATGCGCATTCGTGAA
    GAGGTCGGCAAGTACATCCAGCGTTTACAAGCTCTAGCCCAAGGAATTGCGACGGTTGAT
    GTCTTACAGAGTCTGGCGGTTGTGGCTGAAACCCAGCATTTGATTCGACCTGAGTTTGGT
    GACGATTCACAAATTGATATCCGGAAAGGGCGCCATGCTGTCGTTGAAAAGGTTATGGGG
    GCTCAGACCTATATTCCAAATACGATTCAGATGGCAGAAGATACCAGTATTCAACTGGTT
    ACAGGGCCAAACATGAGTGGGAAGTCTACCTATATGCGTCAGTTAGCCATGACGGCGGTT
    ATGGCCCAGCTGGGTTCCTATGTTCCTGCTGAAAGCGCCCATTTACCGATTTTTGATGCG
    ATTTTTACCCGTATCGGAGCAGCAGATGACTTGGTTTCGGGTCAGTCAACCTTTATGGTG
    GAGATGATGGAGGCCAATAATGCCATTTCGCATGCGACCAAGAACTCTCTCATTCTCTTT
    GATGAATTGGGACGTGGAACTGCAACTTATGACGGGATGGCTCTTGCTCAGTCCATCATC
    GAATATATCCATGAGCACATCGGAGCTAAGACCCTCTTTGCGACCCACTACCATGAGTTG
    ACTAGTCTGGAGTCTAGTTTACAACACTTGGTCAATGTCCACGTGGCAACTTTGGAGCAG
    GATGGGCAGGTCACCTTCCTTCACAAGATTGAACCGGGACCAGCTGATAAATCCTACGGT
    ATCCATGTTGCCAAGATTGCTGGCTTGCCAGCAGACCTTTTAGCAAGGGCGGATAAGATT
    TTGACTCAGCTAGAGAATCAAGGAACAGAGAGTCCTCCTCCCATGAGACAAACTAGTGCT
    GTCACTGAACAGATTTCACTCTTTGATAGGGCAGAAGAGCATCCTATCCTAGCAGAATTA
    GCTAAACTGGATGTGTATAATATGACACCTATGCAGGTTATGAATGTCTTAGTAGAGTTA
    AAACAGAAACTATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2160
    2220
    2280
    2340
    2400
    2460
    2520
    2535

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: EL263_RS10380 [old locus tag: SPAT_1967 ]
  • symbol: MutS
  • description: DNA mismatch repair protein MutS
  • length: 844
  • theoretical pI: 4.94953
  • theoretical MW: 94847.7
  • GRAVY: -0.194668

⊟Function[edit | edit source]

  • TIGRFAM:
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA mismatch repair protein MutS (TIGR01070; HMM-score: 1332.2)
    and 1 more
    Genetic information processing DNA metabolism Other MutS2 family protein (TIGR01069; HMM-score: 152.8)
  • TheSEED: data available for D39, Hungary19A-6
  • PFAM:
    P-loop_NTPase (CL0023) MutS_V; MutS domain V (PF00488; HMM-score: 273.4)
    and 9 more
    no clan defined MutS_III; MutS domain III (PF05192; HMM-score: 151.8)
    MutS_I; MutS domain I (PF01624; HMM-score: 148.1)
    MutS_IV; MutS family domain IV (PF05190; HMM-score: 100.1)
    MutS_II; MutS domain II (PF05188; HMM-score: 63.8)
    P-loop_NTPase (CL0023) AAA_14; AAA domain (PF13173; HMM-score: 17.8)
    AAA_28; AAA domain (PF13521; HMM-score: 14.4)
    no clan defined DUF421; Protein of unknown function (DUF421) (PF04239; HMM-score: 13.6)
    P-loop_NTPase (CL0023) AAA_29; P-loop containing region of AAA domain (PF13555; HMM-score: 13.4)
    ATPase_2; ATPase domain predominantly from Archaea (PF01637; HMM-score: 12.7)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 1.78
    • Cytoplasmic Membrane Score: 8.16
    • Cellwall Score: 0.06
    • Extracellular Score: 0.01
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.002123
    • TAT(Tat/SPI): 0.000271
    • LIPO(Sec/SPII): 0.000181
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000963680 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MAIEKLSPGMQQYVDIKKQYPDAFLLFRMGDFYELFYEDAVNAAQILEISLTSRNKNADNPIPMAGVPYHSAQQYIDVLIEQGYKVAIAEQMEDPKQAVGVVKREVVQVITPGTVVDSSKPDSQNNFLVSIDREGNQFGLAYMDLVTGDFYVTGLLDFTLVCGEIRNLKAREVVLGYDLSEEEEQILSRQMNLVLSYEKESFEDLHLLDLRLATVEQTASSKLLQYVHRTQMRELNHLKPVIRYEIKDFLQMDYATKASLDLVENARSGKKQGSLFWLLDETKTAMGMRLLRSWIHRPLIDKERIVQRQEVVQVFLDHFFERSDLTDSLKGVYDIERLASRVSFGKTNPKDLLQLATTLSSVPRIRAILEGMEQPTLAYLIAQLDAIPELESLISAAIAPEAPHVITDGGIIRTGFDETLDKYRCVLREGTSWIAEIEAKERENSGISTLKIDYNKKDGYYFHVTNSQLGNVPAHFFRKATLKNSERFGTEELARIEGDMLEAREKSANLEYEIFMRIREEVGKYIQRLQALAQGIATVDVLQSLAVVAETQHLIRPEFGDDSQIDIRKGRHAVVEKVMGAQTYIPNTIQMAEDTSIQLVTGPNMSGKSTYMRQLAMTAVMAQLGSYVPAESAHLPIFDAIFTRIGAADDLVSGQSTFMVEMMEANNAISHATKNSLILFDELGRGTATYDGMALAQSIIEYIHEHIGAKTLFATHYHELTSLESSLQHLVNVHVATLEQDGQVTFLHKIEPGPADKSYGIHVAKIAGLPADLLARADKILTQLENQGTESPPPMRQTSAVTEQISLFDRAEEHPILAELAKLDVYNMTPMQVMNVLVELKQKL

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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