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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 14-DEC-2020

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae ATCC 49619
  • locus tag: EL263_RS11000 [old locus tag: SPAT_2081 ]
  • pan locus tag?: PNEUPAN003926000
  • symbol: hk06
  • pan gene symbol?: hk06
  • synonym:
  • product: two-component system sensor histidine kinase HK06

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: EL263_RS11000 [old locus tag: SPAT_2081 ]
  • symbol: hk06
  • product: two-component system sensor histidine kinase HK06
  • replicon: chromosome
  • strand: -
  • coordinates: 2049902..2051242
  • length: 1341
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_AP018938 (2049902..2051242) NCBI
  • BioCyc: EL263_RS11000 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_2019 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    ATGATAAAAAATCCTAAATTATTAACCAAGTCTTTTTTAAGAAGTTTTGCAATTCTAGGT
    GGTGTTGGTCTAGTCATTCATATAGCTATTTATTTGACCTTTCCTTTTTATTATATTCAA
    CTGGAGGGGGAAAAGTTTAATGAGAGCGCAAGAGTGTTTACGGAGTATTTAAAGACTAAG
    ACATCTGATGAAATTCCAAGCTTACTCCAGTCTTATTCAAAGTCCTTGACCATATCTGCT
    CACCTTAAAAGAGATATTGTAGATAAGCGGCTCCCTCTTGTGCATGACTTGGATATTAAA
    GATGGAAAGCTATCAAATTATATCGTGATGTTAGATATGTCTGTTAGTACAGCAGATGGT
    AAACAGGTAACCGTGCAATTTGTTCACGGGGTAGATGTCTACAAAGAAGCAAAGAATATT
    TTGCTTTTGTATCTCCCATATACATTTTTGGTTACAATTGCTTTTTCCTTTGTTTTTTCT
    TATTTTTATACTAAACGCTTGCTCAATCCTCTTTTTTACATTTCAGAAGTGACTAGTAAA
    ATGCAAGATTTGGATGACAATATTCGTTTTGATGAAAGTAGGAAAGATGAAGTTGGTGAA
    GTTGGTGAAGTTGGAAAACAGATTAATGGTATGTATGAGCACTTGTTGAAGGTTATTCAT
    GAGTTGGAAAGTCGTAATGAGCAAATTGTAAAATTGCAAAATCAAAAGGTTTCCTTTGTC
    CGCGGAGCATCACATGAGTTGAAAACCCCTTTAGCCAGTCTTAGAATTATCCTAGAGAAT
    ATGCAGCATAATATTGGAGATTACAAAGATCATCCAAAATATATTGCAAAGAGTATAAAT
    AAGATTGACCAGATGAGCCACTTATTGGAAGAAGTACTGGAGTCTTCTAAATTCCAAGAG
    TGGACAGAGTGTCGTGAGACCTTGACTGTTAAGCCAGTTTTAGTAGATATTTTATCACGT
    TATCAAGAATTAGCTCATTCAATAGGTGTTACAATTGAAAATCAATTGACAGATGCTACC
    AGGGTCGTCATGAGTCTTAGGGCATTGGATAAGGTTTTGACAAACCTGATTAGTAATGCA
    ATTAAATATTCAGATAAAAATGGGCGCGTAATCATATCCGAGCAAGATGGCTATCTCTCT
    ATCAAAAATACATGTGCGCCTCTAAGTGACCAAGAACTAGAACATTTATTTGATATATTC
    TATCATTCTCAAATCGTGACAGATAAGGATGAAAGTTCCGGTTTGGGTCTTTACATTGTG
    AATAATATTTTAGAAAGCTATCAAATGGATTATAGTTTTCTCCCTTATGAACACGGTATG
    GAATTTAAGATTAGCTTGTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1341

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: EL263_RS11000 [old locus tag: SPAT_2081 ]
  • symbol: Hk06
  • description: two-component system sensor histidine kinase HK06
  • length: 446
  • theoretical pI: 6.16233
  • theoretical MW: 51273.6
  • GRAVY: -0.13991

⊟Function[edit | edit source]

  • TIGRFAM:
    Signal transduction Signal transduction Two-component systems phosphate regulon sensor kinase PhoR (TIGR02966; EC 2.7.3.-; HMM-score: 94)
    and 5 more
    heavy metal sensor kinase (TIGR01386; EC 2.7.13.3; HMM-score: 73.8)
    proteobacterial dedicated sortase system histidine kinase (TIGR03785; HMM-score: 60.3)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking putative PEP-CTERM system histidine kinase (TIGR02916; EC 2.7.13.3; HMM-score: 33.4)
    Signal transduction Signal transduction Two-component systems putative PEP-CTERM system histidine kinase (TIGR02916; EC 2.7.13.3; HMM-score: 33.4)
    Signal transduction Signal transduction Two-component systems TMAO reductase sytem sensor TorS (TIGR02956; EC 2.7.13.3; HMM-score: 32.7)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    His_Kinase_A (CL0025) HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (PF02518; HMM-score: 40.1)
    HisKA; His Kinase A (phospho-acceptor) domain (PF00512; HMM-score: 37.7)
    and 11 more
    HAMP (CL0681) HAMP; HAMP domain (PF00672; HMM-score: 22.4)
    His_Kinase_A (CL0025) HATPase_c_5; GHKL domain (PF14501; HMM-score: 19.7)
    no clan defined LHC; Antenna complex alpha/beta subunit (PF00556; HMM-score: 17.6)
    PMT2_N; Phosphoethanolamine N-methyltransferase 2 N-terminal (PF17987; HMM-score: 16.6)
    DUF6674; Family of unknown function (DUF6674) (PF20379; HMM-score: 16.6)
    DUF1216; Protein of unknown function (DUF1216) (PF06746; HMM-score: 15.9)
    Com_YlbF; Control of competence regulator ComK, YlbF/YmcA (PF06133; HMM-score: 14.1)
    SNARE-fusion (CL0445) Syntaxin; Syntaxin (PF00804; HMM-score: 13.2)
    ArdcN (CL0700) BHD_1; Rad4 beta-hairpin domain 1 (PF10403; HMM-score: 12.4)
    no clan defined Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57 (PF06657; HMM-score: 11.1)
    DUF1664; Protein of unknown function (DUF1664) (PF07889; HMM-score: 9.7)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.89
    • Cytoplasmic Membrane Score: 0.09
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 2
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.006266
    • TAT(Tat/SPI): 0.000989
    • LIPO(Sec/SPII): 0.002236
  • predicted transmembrane helices (TMHMM): 2

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000594659 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MIKNPKLLTKSFLRSFAILGGVGLVIHIAIYLTFPFYYIQLEGEKFNESARVFTEYLKTKTSDEIPSLLQSYSKSLTISAHLKRDIVDKRLPLVHDLDIKDGKLSNYIVMLDMSVSTADGKQVTVQFVHGVDVYKEAKNILLLYLPYTFLVTIAFSFVFSYFYTKRLLNPLFYISEVTSKMQDLDDNIRFDESRKDEVGEVGEVGKQINGMYEHLLKVIHELESRNEQIVKLQNQKVSFVRGASHELKTPLASLRIILENMQHNIGDYKDHPKYIAKSINKIDQMSHLLEEVLESSKFQEWTECRETLTVKPVLVDILSRYQELAHSIGVTIENQLTDATRVVMSLRALDKVLTNLISNAIKYSDKNGRVIISEQDGYLSIKNTCAPLSDQELEHLFDIFYHSQIVTDKDESSGLGLYIVNNILESYQMDYSFLPYEHGMEFKISL

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Zhuo Ma, Jing-Ren Zhang
RR06 activates transcription of spr1996 and cbpA in Streptococcus pneumoniae.
J Bacteriol: 2007, 189(6);2497-509
[PubMed:17220227] [WorldCat.org] [DOI] (P p)Alistair J Standish, Uwe H Stroeher, James C Paton
The pneumococcal two-component signal transduction system RR/HK06 regulates CbpA and PspA by two distinct mechanisms.
J Bacteriol: 2007, 189(15);5591-600
[PubMed:17526693] [WorldCat.org] [DOI] (P p)Jason W Rosch, Beth Mann, Justin Thornton, Jack Sublett, Elaine Tuomanen
Convergence of regulatory networks on the pilus locus of Streptococcus pneumoniae.
Infect Immun: 2008, 76(7);3187-96
[PubMed:18443093] [WorldCat.org] [DOI] (I p)

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