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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 14-DEC-2020

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae HU-OH
  • locus tag: EL271_RS01675 [old locus tag: SPOH_0304 ]
  • pan locus tag?: PNEUPAN001134000
  • symbol: EL271_RS01675
  • pan gene symbol?: clpL
  • synonym:
  • product: ATP-dependent Clp protease ATP-binding subunit

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: EL271_RS01675 [old locus tag: SPOH_0304 ]
  • symbol: EL271_RS01675
  • product: ATP-dependent Clp protease ATP-binding subunit
  • replicon: chromosome
  • strand: +
  • coordinates: 296475..298580
  • length: 2106
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_AP018937 (296475..298580) NCBI
  • BioCyc: EL271_RS01675 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0308 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    ATGAACAACAACTTTAATAATTTTAACAACATGGATGATTTATTTAACCAATTGATGGGT
    GGTATGCGTGGATACAGTTCTGAAAATCGCCGTTATTTGATTAATGGACGTGAAGTGACA
    CCTGAGGAATTTGCTCACTATCGTGCGACTGGTCAATTACCAGGAAATGCAGAATCTGAT
    CTGCAAATGCAACAACCGGCATCAGGTATGAAACAAGACGGTGTCCTTGCAAAACTGGGT
    CGAAACTTGACCGCAGAAGCGCGTGAGGGCAAGCTGGATCCTGTTATCGGACGAAACAAG
    GAAATTCAAGAAACATCTGAAATTCTTTCACGTCGTACCAAGAACAATCCTGTTCTGGTT
    GGAGATGCAGGTGTTGGTAAGACAGCAGTCGTTGAAGGACTAGCGCAAGCCATTGTGAAC
    GGAGATGTCCCAGCTGCCATTAAGAATAAGGAAATCATTTCCATTGATATCTCAGGTCTT
    GAGGCTGGTACTCAATACCGTGGTAGCTTTGAAGAAAACGTTCAAAATTTAGTCAATGAA
    GTGAAAGAAGCAGGGAATATTATTCTCTTCTTTGATGAAATTCACCAAATTCTAGGTGCT
    GGTAGCACTGGTGGAGACAGTGGATCTAAAGGGCTTGCGGATATTCTTAAGCCAGCTCTC
    TCTCGTGGAGAATTGACCGTGATTGGGGCAACGACTCAAGACGAATACCGTAACACTATC
    TTGAAGAATGCAGCTCTTGCTCGTCGTTTCAATGAAGTCAAGGTAAATGCTCCTTCAGCA
    GAGGATACTTTTAAAATCCTTCAAGGAATTCGTGACCTTTATCAACAACACCACAATGTC
    ATCTTGCCAGATGAAGTTTTGAAAGCAGCGGTGGATTATTCTGTTCAGTATATTCCTCAA
    CGTAGCTTGCCAGATAAGGCTATCGACCTTGTCGATGTAACGGCAGCTCACTTGGCAGCT
    CAGCATCCTGTAACGGATGTCCATGCTGTTGAACGTGAAATTGAGGCAGAAAAAGACAAG
    CAAGAAAAAGCAGTTGAGGCAGAAGATTTTGAAGCAGCTCTAAACTATAAAACACGCATC
    GCAGAATTGGAAAAGAAAATCGAAAACCACACAGAAGATATGAAAGTGACAGCAAGTGTC
    AACGATGTGGCTGAATCTGTAGAACGGATGACGGGTATTCCAGTGTCACAAATGGGAGCA
    TCTGATATCGAACGTTTGAAAGATATGGCTCATCGTCTGCAAGATAAGGTAATCGGTCAA
    GATAAGGCAGTTGAAGCTGTAGCCCGTGCCATCCGTCGTAACCGTGCTGGTTTTGATGAA
    GGTAATCGCCCAATTGGTAGCTTCCTCTTTGTAGGACCTACTGGGGTTGGTAAGACAGAA
    CTTGCTAAACAATTGGCGCTAGATATGTTTGGAACCAAGGATGCGATCATCCGTTTGGAT
    ATGTCTGAATACAGTGACCGCACAGCCGTTTCTAAGCTAATTGGTACAACAGCAGGCTAT
    GTGGGTTATGATGACAATAGCAATACCTTGACAGAACGTGTTCGTCGCAATCCATACTCT
    ATCATTCTCTTGGATGAAATTGAAAAGGCTGATCCTCAAGTCATTACCCTTCTCCTCCAA
    GTTCTAGATGATGGTCGTTTGACAGATGGTCAAGGAAATACAGTAAACTTCAAGAACACT
    GTCATTATTGCGACCTCAAATGCTGGATTTGGCTATGAAGCCAACTTGACAGAAGATGCG
    GACAAACCAGAATTGATGGACCGTTTGAAACCATTCTTCCGTCCAGAATTCCTCAACCGC
    TTTAATGCAGTTATTGAGTTCTCACACTTGACTAAGGAAGACCTTTCTAAGATTGTAGAC
    TTGATGTTGACTGAAGTCAATCAAACCTTAGCTAAAAAAGAGATTGATTTAACAGTCAGT
    CAAGCGGCTAAAGACTATATCACAGAAGAAGGCTATGACGAAGTCATGGGTGTTCGTCCT
    CTCCGTCGCGTGGTTGAACAAGAAATTCGGGATAAGGTGACAGACTTCCACTTGGATCAT
    TTAGATGCCAAACACCTAGAAGCAGATATGGAAGATGGCGTTTTGGTTATTCGTGAGAAA
    GCCTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2106

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: EL271_RS01675 [old locus tag: SPOH_0304 ]
  • symbol: EL271_RS01675
  • description: ATP-dependent Clp protease ATP-binding subunit
  • length: 701
  • theoretical pI: 4.71343
  • theoretical MW: 77591.8
  • GRAVY: -0.420114

⊟Function[edit | edit source]

  • TIGRFAM:
    Genetic information processing Protein fate Protein folding and stabilization ATP-dependent chaperone protein ClpB (TIGR03346; HMM-score: 713.2)
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides ATP-dependent Clp protease ATP-binding subunit ClpA (TIGR02639; HMM-score: 650.1)
    Cellular processes Cellular processes Pathogenesis type VI secretion ATPase, ClpV1 family (TIGR03345; HMM-score: 593.5)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type VI secretion ATPase, ClpV1 family (TIGR03345; HMM-score: 593.5)
    and 19 more
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides ATP-dependent Clp protease, ATP-binding subunit ClpX (TIGR00382; HMM-score: 44.2)
    Genetic information processing Protein fate Protein folding and stabilization ATP-dependent Clp protease, ATP-binding subunit ClpX (TIGR00382; HMM-score: 44.2)
    Cellular processes Cellular processes Chemotaxis and motility flagellar biosynthesis protein FlhF (TIGR03499; HMM-score: 35)
    AAA family ATPase, CDC48 subfamily (TIGR01243; HMM-score: 27.1)
    Cellular processes Cellular processes Sporulation and germination stage V sporulation protein K (TIGR02881; HMM-score: 26.6)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA polymerase III, subunit gamma and tau (TIGR02397; EC 2.7.7.7; HMM-score: 25.6)
    Genetic information processing Protein fate Protein folding and stabilization ATP-dependent protease HslVU, ATPase subunit (TIGR00390; HMM-score: 23.9)
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides putative ATP-dependent protease (TIGR00764; HMM-score: 23.1)
    Cellular processes Cellular processes Other gas vesicle protein GvpN (TIGR02640; HMM-score: 23.1)
    Signal transduction Regulatory functions DNA interactions psp operon transcriptional activator (TIGR02974; HMM-score: 21.9)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair orc1/cdc6 family replication initiation protein (TIGR02928; HMM-score: 20.8)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DnaA regulatory inactivator Hda (TIGR03420; HMM-score: 20.3)
    CbbX protein (TIGR02880; HMM-score: 16.8)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA polymerase III, delta' subunit (TIGR00678; EC 2.7.7.7; HMM-score: 16.6)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair Holliday junction DNA helicase RuvB (TIGR00635; EC 3.6.4.12; HMM-score: 16.5)
    Cellular processes Cellular processes Sporulation and germination ATP-dependent protease LonB (TIGR02902; EC 3.4.21.-; HMM-score: 15.1)
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides ATP-dependent protease LonB (TIGR02902; EC 3.4.21.-; HMM-score: 15.1)
    Genetic information processing Mobile and extrachromosomal element functions Other conjugative coupling factor TraD, SXT/TOL subfamily (TIGR03743; HMM-score: 13)
    Genetic information processing Protein synthesis tRNA and rRNA base modification tRNA threonylcarbamoyl adenosine modification protein YjeE (TIGR00150; HMM-score: 11.9)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    P-loop_NTPase (CL0023) AAA_2; AAA domain (Cdc48 subfamily) (PF07724; HMM-score: 167.2)
    and 47 more
    AAA; ATPase family associated with various cellular activities (AAA) (PF00004; HMM-score: 87.9)
    AAA_lid (CL0671) AAA_lid_9; AAA lid domain (PF17871; HMM-score: 84)
    ClpB_D2-small; C-terminal, D2-small domain, of ClpB protein (PF10431; HMM-score: 73)
    P-loop_NTPase (CL0023) AAA_5; AAA domain (dynein-related subfamily) (PF07728; HMM-score: 57.9)
    Sigma54_activat; Sigma-54 interaction domain (PF00158; HMM-score: 55.3)
    AAA_16; AAA ATPase domain (PF13191; HMM-score: 44.7)
    AAA_14; AAA domain (PF13173; HMM-score: 41.1)
    ATPase_2; ATPase domain predominantly from Archaea (PF01637; HMM-score: 36.3)
    AAA_22; AAA domain (PF13401; HMM-score: 31.9)
    AAA_7; P-loop containing dynein motor region (PF12775; HMM-score: 26.2)
    DUF815; Protein of unknown function (DUF815) (PF05673; HMM-score: 26)
    TniB; Bacterial TniB protein (PF05621; HMM-score: 24.5)
    AAA_18; AAA domain (PF13238; HMM-score: 24.2)
    TsaE; Threonylcarbamoyl adenosine biosynthesis protein TsaE (PF02367; HMM-score: 24.1)
    NACHT; NACHT domain (PF05729; HMM-score: 23.7)
    AAA_3; ATPase family associated with various cellular activities (AAA) (PF07726; HMM-score: 23)
    RNA_helicase; RNA helicase (PF00910; HMM-score: 22.8)
    Roc; Ras of Complex, Roc, domain of DAPkinase (PF08477; HMM-score: 22.1)
    AAA_23; AAA domain (PF13476; HMM-score: 22.1)
    RsgA_GTPase; RsgA GTPase (PF03193; HMM-score: 21.6)
    RuvB_N; Holliday junction DNA helicase RuvB P-loop domain (PF05496; HMM-score: 21.2)
    IstB_IS21; IstB-like ATP binding protein (PF01695; HMM-score: 20.3)
    Mg_chelatase; Magnesium chelatase, subunit ChlI (PF01078; HMM-score: 19.4)
    ResIII; Type III restriction enzyme, res subunit (PF04851; HMM-score: 19)
    AAA_33; AAA domain (PF13671; HMM-score: 18.9)
    AAA_25; AAA domain (PF13481; HMM-score: 18.8)
    AAA_30; AAA domain (PF13604; HMM-score: 18.8)
    AAA_24; AAA domain (PF13479; HMM-score: 18.2)
    bpMoxR; MoxR domain in the MoxR-vWA-beta-propeller ternary systems (PF20030; HMM-score: 18)
    Zeta_toxin; Zeta toxin (PF06414; HMM-score: 17.4)
    AAA_lid (CL0671) UVR; UvrB/uvrC motif (PF02151; HMM-score: 17)
    P-loop_NTPase (CL0023) AAA_19; AAA domain (PF13245; HMM-score: 16.8)
    VirE; Virulence-associated protein E (PF05272; HMM-score: 16.4)
    SRP54; SRP54-type protein, GTPase domain (PF00448; HMM-score: 15.8)
    ABC_tran; ABC transporter (PF00005; HMM-score: 15.3)
    PhoH; PhoH-like protein (PF02562; HMM-score: 14.6)
    AAA_29; P-loop containing region of AAA domain (PF13555; HMM-score: 14.4)
    Ras; Ras family (PF00071; HMM-score: 14)
    AAA_21; AAA domain, putative AbiEii toxin, Type IV TA system (PF13304; HMM-score: 13.8)
    AAA_28; AAA domain (PF13521; HMM-score: 13.8)
    no clan defined DUF1380; Protein of unknown function (DUF1380) (PF07128; HMM-score: 13.2)
    P-loop_NTPase (CL0023) NB-ARC; NB-ARC domain (PF00931; HMM-score: 13.1)
    Viral_Gag (CL0148) Gag_p24; gag protein p24 N-terminal domain (PF00607; HMM-score: 13)
    P-loop_NTPase (CL0023) TIP49; TIP49 P-loop domain (PF06068; HMM-score: 12.7)
    Torsin; Torsin (PF06309; HMM-score: 12.5)
    cobW; CobW/HypB/UreG, nucleotide-binding domain (PF02492; HMM-score: 11.1)
    no clan defined LUC7; LUC7 N_terminus (PF03194; HMM-score: 10.5)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.89
    • Cytoplasmic Membrane Score: 0.09
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.025085
    • TAT(Tat/SPI): 0.006482
    • LIPO(Sec/SPII): 0.002353
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_001063366 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MNNNFNNFNNMDDLFNQLMGGMRGYSSENRRYLINGREVTPEEFAHYRATGQLPGNAESDLQMQQPASGMKQDGVLAKLGRNLTAEAREGKLDPVIGRNKEIQETSEILSRRTKNNPVLVGDAGVGKTAVVEGLAQAIVNGDVPAAIKNKEIISIDISGLEAGTQYRGSFEENVQNLVNEVKEAGNIILFFDEIHQILGAGSTGGDSGSKGLADILKPALSRGELTVIGATTQDEYRNTILKNAALARRFNEVKVNAPSAEDTFKILQGIRDLYQQHHNVILPDEVLKAAVDYSVQYIPQRSLPDKAIDLVDVTAAHLAAQHPVTDVHAVEREIEAEKDKQEKAVEAEDFEAALNYKTRIAELEKKIENHTEDMKVTASVNDVAESVERMTGIPVSQMGASDIERLKDMAHRLQDKVIGQDKAVEAVARAIRRNRAGFDEGNRPIGSFLFVGPTGVGKTELAKQLALDMFGTKDAIIRLDMSEYSDRTAVSKLIGTTAGYVGYDDNSNTLTERVRRNPYSIILLDEIEKADPQVITLLLQVLDDGRLTDGQGNTVNFKNTVIIATSNAGFGYEANLTEDADKPELMDRLKPFFRPEFLNRFNAVIEFSHLTKEDLSKIVDLMLTEVNQTLAKKEIDLTVSQAAKDYITEEGYDEVMGVRPLRRVVEQEIRDKVTDFHLDHLDAKHLEADMEDGVLVIREKA

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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