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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 15-OCT-2021

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae 670-6B
  • locus tag: SP670_RS02050 [old locus tag: SP670_0408 ]
  • pan locus tag?: PNEUPAN001134000
  • symbol: SP670_RS02050
  • pan gene symbol?: clpL
  • synonym:
  • product: ATP-dependent Clp protease ATP-binding subunit

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP670_RS02050 [old locus tag: SP670_0408 ]
  • symbol: SP670_RS02050
  • product: ATP-dependent Clp protease ATP-binding subunit
  • replicon: chromosome
  • strand: +
  • coordinates: 363095..365200
  • length: 2106
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_014498 (363095..365200) NCBI
  • BioCyc: SP670_RS02050 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0308 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    ATGAATAACAACTTTAATAATTTTAATAACATGGATGATTTATTTAACCAATTGATGGGT
    GGTATGCGAGGATATAGTTCTGAAAATCGCCGTTACTTAATTAATGGACGCGAAGTCACA
    CCTGAGGAATTTGCTCACTATCGTGCGACTGGTCAATTACCAGGAAATGCAGAAACTGAT
    GTGCAAATGCCACAACAGGCATCAGGTATGAAACAAGATGGTGTCCTTGCAAAACTAGGT
    CGAAACTTAACAGCAGAAGCGCGTGAGGGCAAGTTGGACCCTGTTATCGGACGAAACAAG
    GAAATTCAAGAAACATCTGAAATCCTCTCACGCCGCACCAAGAACAATCCTGTTTTGGTC
    GGAGATGCAGGTGTTGGTAAGACAGCAGTTGTCGAAGGTCTAGCGCAAGCCATTGTGAAC
    GGAGATGTTCCTGCTGCTATCAAGAACAAGGAAATTATTTCTATTGATATCTCAGGTCTT
    GAGGCTGGTACTCAATACCGTGGTAGCTTTGAAGAAAATGTCCAAAACTTGGTCAATGAA
    GTGAAAGAAGCAGGGAATATTATCCTCTTCTTTGATGAAATTCACCAAATTCTTGGTGCT
    GGTAGCACTGGTGGAGACAGTGGTTCTAAAGGGCTTGCGGATATTCTCAAGCCAGCTCTC
    TCTCGTGGAGAATTGACAGTGATTGGGGCAACAACTCAAGACGAATACCGTAACACCATC
    TTGAAGAATGCTGCTCTTGCTCGTCGTTTCAACGAAGTGAAGGTCAATGCTCCTTCAGCA
    GAGAATACTTTTAACATTCTTCAAGGCATTCGTGACCTCTATCAACAACACCACAATGTC
    ATCTTGCCAGACGAAGTCTTGAAAGCAGCGGTGGATTATTCTGTTCAATACATTCCTCAA
    CGTAGCTTGCCAGATAAGGCTATTGACCTTGTCGATGTAACGGCTGCTCACTTGGCGGCT
    CAACATCCAGTAACAGATGTGCATGCTGTTGAACGAGAAATCGAAACGGAAAAAGACAAG
    CAAGAAAAAGCAGTTGAAGCAGAAGATTTTGAAGCAGCTCTAAACTATAAAACACGCATT
    GCAGAATTGGAAAGGAAAATCGAAAACCACACAGAAGATATGAAAGTGACTGCAAGTGTC
    AACGATGTGGCTGAATCTGTGGAACGAATGACAGGTATCCCAGTATCGCAAATGGGAGCT
    TCAGATATCGAACGTTTGAAAGATATGGCTCATCGCTTGCAAGACAAGGTGATTGGTCAA
    GATAAGGCCGTAGAAGTTGTAGCTCGTGCTATCCGTCGTAACCGTGCTGGTTTTGATGAA
    GGAAATCGCCCAATCGGCAGCTTCCTCTTTGTAGGGTCTACTGGGGTTGGTAAGACGGAG
    CTTGCTAAGCAATTGGCACTCGATATGTTTGGAACCCAGGATGCGATTATCCGTTTGGAT
    ATGTCTGAATACAGTGACCGCACAGCTGTTTCTAAGCTAATTGGTACAACAGCAGGCTAT
    GTGGGTTATGATGACAATAGCAATACCTTAACAGAACGTGTTCGTCGCAATCCATACTCT
    ATCATTCTCTTGGATGAAATTGAAAAGGCTGACCCTCAAGTTATTACCCTTCTCCTCCAA
    GTTCTAGATGATGGTCGTTTGACAGATGGTCAAGGAAATACAGTAAACTTCAAGAACACT
    GTCATTATTGCGACCTCAAATGCTGGATTTGGCTATGAAGCCAACTTGACAGAAGATGCG
    GATAAACCAGAATTGATGGACCGTTTGAACCCCTTCTTCCGTCCAGAACTCCTCAACCGC
    TTTAATGCAGTCATCGAGTTCTCACACTTGACTAAGGAAGACCTTTCTAAGATTGTAGAT
    TTGATGTTGGCTGAAGTTAACCAAACCTTGGCTAAGAAAGACATTGACTTGGTAGTCAGT
    CAAGCGGCTAAAGATTATATCACAGAAGAAGGTTACGACGAAGTCATGGGGGTTCGTCCT
    CTCCGTCGAGTGGTTGAACAAGAAATTCGTGATAAGGTGACAGACTTCCACTTGGATCAT
    TTAGATGCTAAACATCTGGAAGCAGATATGGAAGATGGCGTTTTGGTTATTCGTGAGAAA
    GCCTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2106

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP670_RS02050 [old locus tag: SP670_0408 ]
  • symbol: SP670_RS02050
  • description: ATP-dependent Clp protease ATP-binding subunit
  • length: 701
  • theoretical pI: 4.6561
  • theoretical MW: 77558.6
  • GRAVY: -0.405563

⊟Function[edit | edit source]

  • TIGRFAM:
    Genetic information processing Protein fate Protein folding and stabilization ATP-dependent chaperone protein ClpB (TIGR03346; HMM-score: 704.1)
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides ATP-dependent Clp protease ATP-binding subunit ClpA (TIGR02639; HMM-score: 638.8)
    Cellular processes Cellular processes Pathogenesis type VI secretion ATPase, ClpV1 family (TIGR03345; HMM-score: 587.4)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type VI secretion ATPase, ClpV1 family (TIGR03345; HMM-score: 587.4)
    and 16 more
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides ATP-dependent Clp protease, ATP-binding subunit ClpX (TIGR00382; HMM-score: 39.1)
    Genetic information processing Protein fate Protein folding and stabilization ATP-dependent Clp protease, ATP-binding subunit ClpX (TIGR00382; HMM-score: 39.1)
    Cellular processes Cellular processes Chemotaxis and motility flagellar biosynthesis protein FlhF (TIGR03499; HMM-score: 32.9)
    Cellular processes Cellular processes Sporulation and germination stage V sporulation protein K (TIGR02881; HMM-score: 29.7)
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides putative ATP-dependent protease (TIGR00764; HMM-score: 26.4)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA polymerase III, subunit gamma and tau (TIGR02397; EC 2.7.7.7; HMM-score: 24.1)
    Signal transduction Regulatory functions DNA interactions psp operon transcriptional activator (TIGR02974; HMM-score: 24)
    Genetic information processing Protein fate Protein folding and stabilization ATP-dependent protease HslVU, ATPase subunit (TIGR00390; HMM-score: 23.9)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair orc1/cdc6 family replication initiation protein (TIGR02928; HMM-score: 20.2)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DnaA regulatory inactivator Hda (TIGR03420; HMM-score: 20.2)
    CbbX protein (TIGR02880; HMM-score: 18.5)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA polymerase III, delta' subunit (TIGR00678; EC 2.7.7.7; HMM-score: 15.2)
    Genetic information processing Mobile and extrachromosomal element functions Other conjugative coupling factor TraD, SXT/TOL subfamily (TIGR03743; HMM-score: 13.9)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair Holliday junction DNA helicase RuvB (TIGR00635; EC 3.6.4.12; HMM-score: 13.8)
    Genetic information processing Protein synthesis tRNA and rRNA base modification tRNA threonylcarbamoyl adenosine modification protein YjeE (TIGR00150; HMM-score: 13)
    Genetic information processing Protein synthesis tRNA and rRNA base modification tRNA 2-selenouridine synthase (TIGR03167; EC 2.9.1.-; HMM-score: 12.6)
  • TheSEED: see SP670_0408
  • PFAM:
    P-loop_NTPase (CL0023) AAA_2; AAA domain (Cdc48 subfamily) (PF07724; HMM-score: 165.4)
    and 50 more
    AAA; ATPase family associated with various cellular activities (AAA) (PF00004; HMM-score: 84.4)
    AAA_lid (CL0671) AAA_lid_9; AAA lid domain (PF17871; HMM-score: 83.8)
    ClpB_D2-small; C-terminal, D2-small domain, of ClpB protein (PF10431; HMM-score: 74)
    P-loop_NTPase (CL0023) AAA_5; AAA domain (dynein-related subfamily) (PF07728; HMM-score: 55.6)
    Sigma54_activat; Sigma-54 interaction domain (PF00158; HMM-score: 55.5)
    AAA_16; AAA ATPase domain (PF13191; HMM-score: 39)
    AAA_14; AAA domain (PF13173; HMM-score: 38.6)
    ATPase_2; ATPase domain predominantly from Archaea (PF01637; HMM-score: 33.7)
    AAA_22; AAA domain (PF13401; HMM-score: 28)
    DUF815; Protein of unknown function (DUF815) (PF05673; HMM-score: 27.7)
    AAA_7; P-loop containing dynein motor region (PF12775; HMM-score: 24.4)
    AAA_3; ATPase family associated with various cellular activities (AAA) (PF07726; HMM-score: 23.6)
    TniB; Bacterial TniB protein (PF05621; HMM-score: 23.5)
    NACHT; NACHT domain (PF05729; HMM-score: 23.4)
    TsaE; Threonylcarbamoyl adenosine biosynthesis protein TsaE (PF02367; HMM-score: 23)
    Roc; Ras of Complex, Roc, domain of DAPkinase (PF08477; HMM-score: 22.2)
    RNA_helicase; RNA helicase (PF00910; HMM-score: 21.2)
    RsgA_GTPase; RsgA GTPase (PF03193; HMM-score: 20.2)
    AAA_18; AAA domain (PF13238; HMM-score: 19.7)
    AAA_23; AAA domain (PF13476; HMM-score: 19.7)
    Zeta_toxin; Zeta toxin (PF06414; HMM-score: 19.5)
    RuvB_N; Holliday junction DNA helicase RuvB P-loop domain (PF05496; HMM-score: 18.3)
    Mg_chelatase; Magnesium chelatase, subunit ChlI (PF01078; HMM-score: 18.1)
    AAA_25; AAA domain (PF13481; HMM-score: 17.7)
    AAA_lid (CL0671) UVR; UvrB/uvrC motif (PF02151; HMM-score: 17.6)
    P-loop_NTPase (CL0023) AAA_33; AAA domain (PF13671; HMM-score: 17)
    IstB_IS21; IstB-like ATP binding protein (PF01695; HMM-score: 16.8)
    AAA_30; AAA domain (PF13604; HMM-score: 16.8)
    bpMoxR; MoxR domain in the MoxR-vWA-beta-propeller ternary systems (PF20030; HMM-score: 16.7)
    AAA_24; AAA domain (PF13479; HMM-score: 16.3)
    ResIII; Type III restriction enzyme, res subunit (PF04851; HMM-score: 16.1)
    Ras; Ras family (PF00071; HMM-score: 15.5)
    AAA_19; AAA domain (PF13245; HMM-score: 15.5)
    VirE; Virulence-associated protein E (PF05272; HMM-score: 15.4)
    SRP54; SRP54-type protein, GTPase domain (PF00448; HMM-score: 15.3)
    ABC_tran; ABC transporter (PF00005; HMM-score: 14.7)
    Torsin; Torsin (PF06309; HMM-score: 14.2)
    TrwB_AAD_bind; Type IV secretion-system coupling protein DNA-binding domain (PF10412; HMM-score: 14.2)
    AAA_28; AAA domain (PF13521; HMM-score: 13.9)
    NB-ARC; NB-ARC domain (PF00931; HMM-score: 13.5)
    no clan defined BBP1_C; Spindle pole body component BBP1, C-terminal (PF15272; HMM-score: 13.5)
    P-loop_NTPase (CL0023) AAA_21; AAA domain, putative AbiEii toxin, Type IV TA system (PF13304; HMM-score: 13.3)
    AAA_29; P-loop containing region of AAA domain (PF13555; HMM-score: 13.3)
    DUF87; Helicase HerA, central domain (PF01935; HMM-score: 13.1)
    PhoH; PhoH-like protein (PF02562; HMM-score: 12.8)
    AAA_8; P-loop containing dynein motor region D4 (PF12780; HMM-score: 12.1)
    no clan defined DUF1380; Protein of unknown function (DUF1380) (PF07128; HMM-score: 11.6)
    LUC7; LUC7 N_terminus (PF03194; HMM-score: 11.1)
    P-loop_NTPase (CL0023) cobW; CobW/HypB/UreG, nucleotide-binding domain (PF02492; HMM-score: 10.9)
    TIP49; TIP49 P-loop domain (PF06068; HMM-score: 9.4)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.89
    • Cytoplasmic Membrane Score: 0.09
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.025191
    • TAT(Tat/SPI): 0.006822
    • LIPO(Sec/SPII): 0.002313
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_001063400 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MNNNFNNFNNMDDLFNQLMGGMRGYSSENRRYLINGREVTPEEFAHYRATGQLPGNAETDVQMPQQASGMKQDGVLAKLGRNLTAEAREGKLDPVIGRNKEIQETSEILSRRTKNNPVLVGDAGVGKTAVVEGLAQAIVNGDVPAAIKNKEIISIDISGLEAGTQYRGSFEENVQNLVNEVKEAGNIILFFDEIHQILGAGSTGGDSGSKGLADILKPALSRGELTVIGATTQDEYRNTILKNAALARRFNEVKVNAPSAENTFNILQGIRDLYQQHHNVILPDEVLKAAVDYSVQYIPQRSLPDKAIDLVDVTAAHLAAQHPVTDVHAVEREIETEKDKQEKAVEAEDFEAALNYKTRIAELERKIENHTEDMKVTASVNDVAESVERMTGIPVSQMGASDIERLKDMAHRLQDKVIGQDKAVEVVARAIRRNRAGFDEGNRPIGSFLFVGSTGVGKTELAKQLALDMFGTQDAIIRLDMSEYSDRTAVSKLIGTTAGYVGYDDNSNTLTERVRRNPYSIILLDEIEKADPQVITLLLQVLDDGRLTDGQGNTVNFKNTVIIATSNAGFGYEANLTEDADKPELMDRLNPFFRPELLNRFNAVIEFSHLTKEDLSKIVDLMLAEVNQTLAKKDIDLVVSQAAKDYITEEGYDEVMGVRPLRRVVEQEIRDKVTDFHLDHLDAKHLEADMEDGVLVIREKA

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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