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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 12-FEB-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae HU-OH
  • locus tag: EL271_RS06425 [old locus tag: SPOH_1189 ]
  • pan locus tag?: PNEUPAN002536000
  • symbol: htpX
  • pan gene symbol?: htpX
  • synonym:
  • product: zinc metalloprotease HtpX

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: EL271_RS06425 [old locus tag: SPOH_1189 ]
  • symbol: htpX
  • product: zinc metalloprotease HtpX
  • replicon: chromosome
  • strand: -
  • coordinates: 1206237..1207136
  • length: 900
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_AP018937 (1206237..1207136) NCBI
  • BioCyc: EL271_RS06425 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1138 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    ATGTTGTTTGATCAAATTGCAAGCAATAAACGAAAAACCTGGATTTTGTTGCTGGTATTT
    TTCCTACTCTTAGCTCTTGTTGGTTATGCGGTTGGTTATCTCTTTATAAGATCTGGACTT
    GGTGGTTTGGTTATCGCACTGATTATCGGCTTTATCTACGCTTTGTCTATGATTTTTCAA
    TCGACAGAGATTGTCATGTCCATGAATGGAGCGCGTGAGGTGGATGAGCAAACGGCACCA
    GACCTCTACCATGTAGTGGAAGATATGGCTCTGGTCGCTCAGATTCCTATGCCCCGTATT
    TTCATCATTGATGATCCAGCCTTAAATGCCTTTGCGACAGGTTCTAATCCTCAAAATGCG
    GCTGTTGCTGCGACTTCAGGTCTACTAGCTATCATGAATCGTGAAGAACTAGAAGCTGTT
    ATGGGACATGAAGTCAGTCATATTCGTAATTATGATATCCGTATTTCGACTATTGCAGTT
    GCCCTTGCTAGTGCTATCACCATGCTTTCTAGTATGGCAGGTCGTATGATGTGGTGGGGT
    GGAGCAGGTCGCAGACGAAGTGATGATGACCGAGATGGAAATGGTCTTGAAATCATTATG
    CTAGTGGTTTCCCTACTAGCTATTGTACTGGCACCTCTCGCTGCAACCTTGGTTCAGCTC
    GCTATTTCTCGTCAGAGGGAATTTCTGGCAGATGCATCTAGTGTCGAGCTGACTCGCAAT
    CCCCAGGGAATGATTAATGCCCTAGATAAGTTGGACAATAGCAAACCTATGAGTCGCCAC
    GTCGATGATGCTAGCAGTGCCCTTTATATCAATGCTCCCAAGAAAGGTGGGGGGGTCCAA
    AAACTCTTTTATACCCACCCACCTATCTCAGAACGGATTGAACGTTTAAAACAGATGTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: EL271_RS06425 [old locus tag: SPOH_1189 ]
  • symbol: HtpX
  • description: zinc metalloprotease HtpX
  • length: 299
  • theoretical pI: 6.3665
  • theoretical MW: 32718
  • GRAVY: 0.317726

⊟Function[edit | edit source]

  • reaction:
    EC 3.4.24.-?  ExPASy
  • TIGRFAM:
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    Peptidase_MA (CL0126) Peptidase_M48; Peptidase family M48 (PF01435; HMM-score: 127.1)
    and 5 more
    Peptidase_M56; BlaR1 peptidase M56 (PF05569; HMM-score: 17)
    Peroxisome (CL0484) Reticulon; Reticulon (PF02453; HMM-score: 15.3)
    Peptidase_MA (CL0126) DUF5700; Putative zinc dependent peptidase (DUF5700) (PF18958; HMM-score: 14.5)
    no clan defined SecD-TM1; SecD export protein N-terminal TM region (PF13721; HMM-score: 13.9)
    DUF2207; Predicted membrane protein (DUF2207) (PF09972; HMM-score: 7.9)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 4
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 0.9991
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0009
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.003189
    • TAT(Tat/SPI): 0.001135
    • LIPO(Sec/SPII): 0.016173
  • predicted transmembrane helices (TMHMM): 4

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000895724 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MLFDQIASNKRKTWILLLVFFLLLALVGYAVGYLFIRSGLGGLVIALIIGFIYALSMIFQSTEIVMSMNGAREVDEQTAPDLYHVVEDMALVAQIPMPRIFIIDDPALNAFATGSNPQNAAVAATSGLLAIMNREELEAVMGHEVSHIRNYDIRISTIAVALASAITMLSSMAGRMMWWGGAGRRRSDDDRDGNGLEIIMLVVSLLAIVLAPLAATLVQLAISRQREFLADASSVELTRNPQGMINALDKLDNSKPMSRHVDDASSALYINAPKKGGGVQKLFYTHPPISERIERLKQM

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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