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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 12-FEB-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae NU83127
  • locus tag: EL277_RS10225 [old locus tag: SPNU_1933 ]
  • pan locus tag?: PNEUPAN003617000
  • symbol: EL277_RS10225
  • pan gene symbol?: cof
  • synonym:
  • product: Cof-type HAD-IIB family hydrolase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: EL277_RS10225 [old locus tag: SPNU_1933 ]
  • symbol: EL277_RS10225
  • product: Cof-type HAD-IIB family hydrolase
  • replicon: chromosome
  • strand: -
  • coordinates: 1918645..1920033
  • length: 1389
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_AP018936 (1918645..1920033) NCBI
  • BioCyc: EL277_RS10225 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1794 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    ATGGAAGTCAAAGCTGTTTTTTTTGATATCGATGGAACCTTGGTCAACAATCGCAAGAGT
    GTTTTGAAATCCACTAAGGATGCGATTAAGATTGTCAAAGAACAAGGGGTACTAGTTGGC
    GTAGCGACAGGGCGAGGACCTTTTTTTGTTAAGGAATTGATGGACGATTTGGATCTGGAT
    TTTGCGGTAACCTATAATGGCCAGTATATCTTTAGTAAAGACAGAGTCTTGTTCACGAGC
    CCTATTTCCAAGTTACATTTGCGCCATCTAATTAGCTATGCTAAAAAAGAGGGCACGGAG
    ATTGCTCTAGGGACCAAGGATGCCATGTTGGGTTCTAAAATCATGTCCTTTGGTCTGGGT
    TCTTTTTCCCAACGAATTAGTCGCTTCGTTCCCTCTGTTTTAACTCGGACGGTGAGTCAG
    TCTTTTAATCGCATGGTCAGCAAGGTTGTTCCCCAAAAGGAAGAGGACCTGCTTCACCTG
    ATGAATCAGCCTATCTACCAAGTTTTGATGCTGATGACACCAGAAGAATCTGAGAAGGCG
    GCAGCTGATTTTGAAGACTTGAAATTGACACGTAGCAATCCTTTTGCATCGGATGTCATC
    AATCAGGGAAATTCTAAATTAGAAGGCATTCGCCGAGTTGGGAAAGAATATGGCTTTGAC
    CTCAACCAAGTCATGGCTTTTGGTGACTCAGATAATGATCTTGAAATGCTGGCTGGCGTT
    GGTATGTCGGTCGCTATGGGAAATGGTAGTAGCAGTGTCAAGGAAGCTGCCAAGCACATT
    ACCACTAGCAATCAACAAGATGGAATCCACAAGGCCTTGGAACATTTTGGTGTTTTGTCT
    TCAGAAAAAGTCTTTGTCAGCCGTGACTATCATTTCAATAAGGTCAAGACCTTCCACCAC
    ATGATGGATGAACGAACCCAAGAAGAACCTCGAGCTTGGGATTTAGAGGGTGCAACCCAT
    AGGGCTGGTTTTAAAATAGAAGAATTGGTGGAGTTTGTTCGAGCAGCCAGTCCTTCTGAA
    GAAGATTTTGGTCAAGCTGTATCGCAACTTCATCAGGCCCTTGATAAGGCAGCAGATAAA
    GTAGCCAAGAAGACACCTGCTCAGCAAGATTTGATAGGGCAAGTGGATGCCTTGATTGAC
    ACGCTTTACTTCACCTACGGCAGTTTTGTCTTGATGGGGGTGGACCCAGAACGTATTTTT
    GATATTGTCCATCAGGCCAATATGGGGAAAATTTTTCCAGATGGCAAGGCTCATTTTGAT
    CCAGTGACCCATAAAATCTTAAAACCAGATAATTGGGAAGAAAAATATGCTCCAGAACCT
    GCTATTAAAAAGGAACTGCAGCGCCAGCTCAAGGCTTACGAACGCCATAAAGAGAGAAAT
    AAATCGTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1389

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: EL277_RS10225 [old locus tag: SPNU_1933 ]
  • symbol: EL277_RS10225
  • description: Cof-type HAD-IIB family hydrolase
  • length: 462
  • theoretical pI: 6.81128
  • theoretical MW: 51897.8
  • GRAVY: -0.384848

⊟Function[edit | edit source]

  • TIGRFAM:
    Unknown function Enzymes of unknown specificity Cof-like hydrolase (TIGR00099; HMM-score: 176.6)
    and 24 more
    Unknown function Enzymes of unknown specificity HAD hydrolase, family IIB (TIGR01484; HMM-score: 76.3)
    phosphoglycolate phosphatase, TA0175-type (TIGR01487; EC 3.1.3.18; HMM-score: 74)
    sucrose-phosphate phosphatase subfamily (TIGR01482; EC 3.1.3.-; HMM-score: 62.1)
    mannosyl-3-phosphoglycerate phosphatase family (TIGR01486; EC 3.1.3.-; HMM-score: 37.4)
    Unknown function Enzymes of unknown specificity HAD hydrolase, family IB (TIGR01490; HMM-score: 36.6)
    Metabolism Amino acid biosynthesis Serine family phosphoserine phosphatase SerB (TIGR00338; EC 3.1.3.3; HMM-score: 33)
    sucrose-phosphate synthase, sucrose phosphatase-like domain (TIGR02471; HMM-score: 31.4)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family (TIGR01670; EC 3.1.3.45; HMM-score: 30.8)
    Unknown function Enzymes of unknown specificity HAD phosphoserine phosphatase-like hydrolase, family IB (TIGR01488; HMM-score: 27.6)
    Unknown function Enzymes of unknown specificity HAD hydrolase, family IIIA (TIGR01662; HMM-score: 27)
    HAD hydrolase, TIGR02253 family (TIGR02253; HMM-score: 24.9)
    mannosyl-3-phosphoglycerate phosphatase (TIGR02461; EC 3.1.3.70; HMM-score: 24.5)
    Unknown function General mannosyl-3-phosphoglycerate phosphatase homolog (TIGR02463; EC 3.1.3.-; HMM-score: 24.3)
    Metabolism Energy metabolism Anaerobic phenylphosphate carboxylase, delta subunit (TIGR02726; HMM-score: 23.1)
    phosphoserine phosphatase-like hydrolase, archaeal (TIGR01491; HMM-score: 21.3)
    Metabolism Transport and binding proteins Cations and iron carrying compounds cadmium-translocating P-type ATPase (TIGR01512; EC 3.6.3.3; HMM-score: 15.7)
    sucrose phosphatase (TIGR01485; EC 3.1.3.24; HMM-score: 15.3)
    histidinol-phosphate phosphatase domain (TIGR01656; HMM-score: 14.4)
    Unknown function Enzymes of unknown specificity HAD hydrolase, family IA, variant 3 (TIGR01509; HMM-score: 13.6)
    Metabolism Energy metabolism Amino acids and amines choline TMA-lyase-activating enzyme (TIGR04395; EC 1.97.-.-; HMM-score: 13)
    beta-phosphoglucomutase family hydrolase (TIGR02009; HMM-score: 12.6)
    phosphonatase-like hydrolase (TIGR03351; HMM-score: 12.6)
    heavy metal translocating P-type ATPase (TIGR01525; EC 3.6.3.-; HMM-score: 12.2)
    Metabolism Energy metabolism Sugars phosphoglycolate phosphatase, bacterial (TIGR01449; EC 3.1.3.18; HMM-score: 11.3)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    HAD (CL0137) Hydrolase_3; haloacid dehalogenase-like hydrolase (PF08282; HMM-score: 214.3)
    and 9 more
    MazG (CL0231) PRA-PH; Phosphoribosyl-ATP pyrophosphohydrolase (PF01503; HMM-score: 96.7)
    HAD (CL0137) S6PP; Sucrose-6F-phosphate phosphohydrolase (PF05116; HMM-score: 48.4)
    Hydrolase; haloacid dehalogenase-like hydrolase (PF00702; HMM-score: 42.2)
    HAD; haloacid dehalogenase-like hydrolase (PF12710; HMM-score: 40.1)
    HAD_2; haloacid dehalogenase-like hydrolase (PF13419; HMM-score: 29.1)
    Hydrolase_6; haloacid dehalogenase-like hydrolase (PF13344; HMM-score: 16)
    no clan defined MT0933_antitox; MT0933-like antitoxin protein (PF14013; HMM-score: 15.3)
    DUF5499; Family of unknown function (DUF5499) (PF17603; HMM-score: 13.1)
    HAD (CL0137) Acid_phosphat_B; HAD superfamily, subfamily IIIB (Acid phosphatase) (PF03767; HMM-score: 12.9)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.444
    • Cytoplasmic Membrane Score: 0.5146
    • Cell wall & surface Score: 0.0009
    • Extracellular Score: 0.0405
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.003098
    • TAT(Tat/SPI): 0.000244
    • LIPO(Sec/SPII): 0.000312
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000453137 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MEVKAVFFDIDGTLVNNRKSVLKSTKDAIKIVKEQGVLVGVATGRGPFFVKELMDDLDLDFAVTYNGQYIFSKDRVLFTSPISKLHLRHLISYAKKEGTEIALGTKDAMLGSKIMSFGLGSFSQRISRFVPSVLTRTVSQSFNRMVSKVVPQKEEDLLHLMNQPIYQVLMLMTPEESEKAAADFEDLKLTRSNPFASDVINQGNSKLEGIRRVGKEYGFDLNQVMAFGDSDNDLEMLAGVGMSVAMGNGSSSVKEAAKHITTSNQQDGIHKALEHFGVLSSEKVFVSRDYHFNKVKTFHHMMDERTQEEPRAWDLEGATHRAGFKIEELVEFVRAASPSEEDFGQAVSQLHQALDKAADKVAKKTPAQQDLIGQVDALIDTLYFTYGSFVLMGVDPERIFDIVHQANMGKIFPDGKAHFDPVTHKILKPDNWEEKYAPEPAIKKELQRQLKAYERHKERNKS

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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