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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 15-DEC-2020

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae ASP0581
  • locus tag: EL334_RS10580 [old locus tag: ASP0581_19640 ]
  • pan locus tag?: PNEUPAN003810000
  • symbol: EL334_RS10580
  • pan gene symbol?: adh
  • synonym:
  • product: zinc-dependent alcohol dehydrogenase family protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: EL334_RS10580 [old locus tag: ASP0581_19640 ]
  • symbol: EL334_RS10580
  • product: zinc-dependent alcohol dehydrogenase family protein
  • replicon: chromosome
  • strand: -
  • coordinates: 1939092..1940150
  • length: 1059
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_AP019192 (1939092..1940150) NCBI
  • BioCyc: EL334_RS10580 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1865 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    ATGAAAGCCTATACTTATGTTAAACCAGGACTTGCTTCTTTTGTTGATGTAGACAAACCA
    GTTATTCGCAAGCCAACAGATGCTATTGTGCGTATTGTGAAAACCACTATTTGTGGAACA
    GACCTCCATATTATCAAAGGGGATGTTCCTACTTGCCAAAGTGGTACCATTCTTGGCCAC
    GAAGGGATTGGGATTGTTGAAGAAGTTGGGGAAGGAGTTTCCAACTTCAAAAAAGGTGAC
    AAGGTCTTGATTTCTTGCGTCTGTGCCTGTGGTAAATGCTACTACTGTAAAAAAGGAATT
    TATGCTCACTGTGAAGACGAAGGGGGCTGGATTTTCGGTCACTTGATTGATGGTATGCAG
    GCTGAATATCTACGTGTCCCTCATGCAGATAATACTCTTTACCATACTCCAGAAGACTTG
    TCAGATGAAGCTTTGGTTATGCTGTCAGACATTCTGCCTACTGGATATGAAATTGGTGTC
    TTAAAAGGGAAAGTAGAACCTGGTTGCAGCGTAGCCATTATTGGTTCAGGTCCAGTTGGA
    TTGGCTGCTCTTTTAACAGCCCAATTCTATTCACCAGCTAAATTGATTATGGTAGACCTA
    GACGATAACCGCTTGGAAACTGCCCTATCATTCGGTGCGACTCATAAGGTTAATTCTTCA
    GACCCTGAAAAAGCCATTAAAGAAATTTATGATTTGACAGATGGTCGTGGTGTGGATGTC
    GCTATCGAAGCTGTTGGTATTCCTGCAACATTTGATTTCTGTCAAAAGATTATCGGTGTA
    GACGGAACGGTTGCCAACTGTGGTGTGCATGGTAAACCAGTTGAATTCGATTTAGATAAA
    CTTTGGATTCGCAACATCAATGTAACAACTGGTTTGGTATCTACAAATACGACTCCACAA
    TTGTTGAAAGCACTTGAAAGTCATAAGATTGAACCAGAAAAATTGGTAACTCACTATTTC
    AAACTCAGTGAAATTGAAAAAGCCTACGAAGTCTTCAGTAAGGCAGCAGACCACCATGCC
    ATTAAGGTCATTATCGAAAACGATATCTCAGAAGCCTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1059

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: EL334_RS10580 [old locus tag: ASP0581_19640 ]
  • symbol: EL334_RS10580
  • description: zinc-dependent alcohol dehydrogenase family protein
  • length: 352
  • theoretical pI: 5.12662
  • theoretical MW: 38091.6
  • GRAVY: 0.0465909

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Energy metabolism Amino acids and amines L-threonine 3-dehydrogenase (TIGR00692; EC 1.1.1.103; HMM-score: 169.8)
    Unknown function Enzymes of unknown specificity NDMA-dependent alcohol dehydrogenase, Rxyl_3153 family (TIGR03989; EC 1.1.99.36; HMM-score: 142.7)
    Cellular processes Cellular processes Detoxification S-(hydroxymethyl)mycothiol dehydrogenase (TIGR03451; EC 1.1.1.306; HMM-score: 141.9)
    and 11 more
    Metabolism Central intermediary metabolism One-carbon metabolism formaldehyde dehydrogenase, glutathione-independent (TIGR02819; EC 1.2.1.46; HMM-score: 132.8)
    Cellular processes Cellular processes Detoxification S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase (TIGR02818; EC 1.1.1.1,1.1.1.284; HMM-score: 129.1)
    Metabolism Energy metabolism Fermentation S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase (TIGR02818; EC 1.1.1.1,1.1.1.284; HMM-score: 129.1)
    putative phosphonate catabolism associated alcohol dehydrogenase (TIGR03366; HMM-score: 114.5)
    Metabolism Energy metabolism Fermentation zinc-binding alcohol dehydrogenase family protein (TIGR02822; EC 1.-.-.-; HMM-score: 76.2)
    6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase (TIGR03201; EC 1.1.1.-; HMM-score: 67.3)
    Unknown function Enzymes of unknown specificity putative NAD(P)H quinone oxidoreductase, PIG3 family (TIGR02824; HMM-score: 55.9)
    crotonyl-CoA carboxylase/reductase (TIGR01751; EC 1.3.1.85; HMM-score: 47.3)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Chlorophyll and bacteriochlorphyll chlorophyll synthesis pathway protein BchC (TIGR01202; HMM-score: 36.8)
    Metabolism Energy metabolism Fermentation zinc-binding alcohol dehydrogenase family protein (TIGR02817; HMM-score: 27.4)
    Metabolism Energy metabolism Amino acids and amines sarcosine oxidase, alpha subunit family (TIGR01372; HMM-score: 9.6)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    GroES (CL0296) ADH_N; Alcohol dehydrogenase GroES-like domain (PF08240; HMM-score: 101)
    and 6 more
    NADP_Rossmann (CL0063) ADH_zinc_N; Zinc-binding dehydrogenase (PF00107; HMM-score: 75.8)
    Glu_dehyd_C; Glucose dehydrogenase C-terminus (PF16912; HMM-score: 30.9)
    AlaDh_PNT_C; Alanine dehydrogenase/PNT, C-terminal domain (PF01262; HMM-score: 22.9)
    ADH_zinc_N_2; Zinc-binding dehydrogenase (PF13602; HMM-score: 21.3)
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase (PF07992; HMM-score: 12.7)
    FAD_binding_2; FAD binding domain (PF00890; HMM-score: 11.3)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.043871
    • TAT(Tat/SPI): 0.000298
    • LIPO(Sec/SPII): 0.001667
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000649468 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKAYTYVKPGLASFVDVDKPVIRKPTDAIVRIVKTTICGTDLHIIKGDVPTCQSGTILGHEGIGIVEEVGEGVSNFKKGDKVLISCVCACGKCYYCKKGIYAHCEDEGGWIFGHLIDGMQAEYLRVPHADNTLYHTPEDLSDEALVMLSDILPTGYEIGVLKGKVEPGCSVAIIGSGPVGLAALLTAQFYSPAKLIMVDLDDNRLETALSFGATHKVNSSDPEKAIKEIYDLTDGRGVDVAIEAVGIPATFDFCQKIIGVDGTVANCGVHGKPVEFDLDKLWIRNINVTTGLVSTNTTPQLLKALESHKIEPEKLVTHYFKLSEIEKAYEVFSKAADHHAIKVIIENDISEA

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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