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serotype 4
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EF3030
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serotype 5
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serotype 19F
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serotype 3
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Hu17
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JJA
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MDRSPN001
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TCH8431/19A
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serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 15-OCT-2021

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae 70585
  • locus tag: SP70585_RS10645 [old locus tag: SP70585_2143 ]
  • pan locus tag?: PNEUPAN003810000
  • symbol: SP70585_RS10645
  • pan gene symbol?: adh
  • synonym:
  • product: zinc-dependent alcohol dehydrogenase family protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP70585_RS10645 [old locus tag: SP70585_2143 ]
  • symbol: SP70585_RS10645
  • product: zinc-dependent alcohol dehydrogenase family protein
  • replicon: chromosome
  • strand: -
  • coordinates: 1961599..1962657
  • length: 1059
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    ATGAAAGCCTATACTTATGTTAAACCAGGACTTGCTTCTTTTGTTGATGTAGACAAACCA
    GTTATTCGCAAGCCAACAGATGCTATTGTGCGTATTGTAAAAACCACTATTTGTGGAACA
    GACCTCCATATTATCAAAGGGGATGTTCCTACTTGCCAAAGTGGTACCATTCTTGGCCAC
    GAAGGAATTGGGATTGTTGAAGAAGTTGGGGAAGGAGTTTCCAACTTCAAAAAAGGTGAC
    AAGGTCTTGATTTCTTGCGTCTGTGCCTGTGGTAAATGCTACTACTGTAAAAAAGGAATT
    TATGCCCACTGTGAAGACGAAGGGGGCTGGATTTTCGGTCACTTGATTGATGGTATGCAG
    GCTGAATATCTACGTGTCCCTCATGCAGATAATACTCTTTACCATACTCCAGAAGACTTG
    TCAGATGAAGCTTTGGTTATGCTGTCAGACATTCTGCCTACTGGATATGAAATTGGTGTC
    TTAAAAGGGAAAGTAGAACCTGGTTGCAGCGTAGCCATTATTGGTTCAGGTCCAGTTGGA
    TTGGCTGCTCTTTTAACAGCCCAATTCTATTCACCAGCTAAATTGATTATGGTGGACTTG
    GATGATAACCGTTTGGATACTGCCCTATCATTCGGTGCTACTCATAAGGTAAACTCTTCA
    GACCCTGAAAAAGCGATAAAAGAAATTTATGATTTGACAGATGGTCGCGGTGTAGATGTC
    GCTATTGAAGCTGTAGGGATTCCTGAAACATTTGATTTCTGTCAAAAGATTATCGGTGTA
    GACGGAACGGTTGCCAACTGTGGTGTGCATGGTAAACCAGTTGAATTCGATTTAGATAAA
    CTTTGGATTCGCAACATCAATGTAACAACTGGTTTGGTATCTACAAATACGACTCCACAA
    TTGTTGAAAGCACTTGAAAGTCATAAGATTGAACCAGAAAAATTGGTAACTCACTATTTC
    AAACTCAGTGAAATTGAAAAAGCCTACGAAGTCTTCAGTAAGGCAGCAGACCACCATGCC
    ATTAAGGTCATTATCGAAAACGATATCTCAGAAGCCTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1059

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP70585_RS10645 [old locus tag: SP70585_2143 ]
  • symbol: SP70585_RS10645
  • description: zinc-dependent alcohol dehydrogenase family protein
  • length: 352
  • theoretical pI: 5.0256
  • theoretical MW: 38135.6
  • GRAVY: 0.0315341

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Energy metabolism Amino acids and amines L-threonine 3-dehydrogenase (TIGR00692; EC 1.1.1.103; HMM-score: 169)
    Unknown function Enzymes of unknown specificity NDMA-dependent alcohol dehydrogenase, Rxyl_3153 family (TIGR03989; EC 1.1.99.36; HMM-score: 144.5)
    Cellular processes Cellular processes Detoxification S-(hydroxymethyl)mycothiol dehydrogenase (TIGR03451; EC 1.1.1.306; HMM-score: 143.8)
    and 11 more
    Metabolism Central intermediary metabolism One-carbon metabolism formaldehyde dehydrogenase, glutathione-independent (TIGR02819; EC 1.2.1.46; HMM-score: 131)
    Cellular processes Cellular processes Detoxification S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase (TIGR02818; EC 1.1.1.1,1.1.1.284; HMM-score: 128.9)
    Metabolism Energy metabolism Fermentation S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase (TIGR02818; EC 1.1.1.1,1.1.1.284; HMM-score: 128.9)
    putative phosphonate catabolism associated alcohol dehydrogenase (TIGR03366; HMM-score: 113.4)
    Metabolism Energy metabolism Fermentation zinc-binding alcohol dehydrogenase family protein (TIGR02822; EC 1.-.-.-; HMM-score: 75.6)
    6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase (TIGR03201; EC 1.1.1.-; HMM-score: 64.7)
    Unknown function Enzymes of unknown specificity putative NAD(P)H quinone oxidoreductase, PIG3 family (TIGR02824; HMM-score: 55.8)
    crotonyl-CoA carboxylase/reductase (TIGR01751; EC 1.3.1.85; HMM-score: 45.7)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Chlorophyll and bacteriochlorphyll chlorophyll synthesis pathway protein BchC (TIGR01202; HMM-score: 36.8)
    Metabolism Energy metabolism Fermentation zinc-binding alcohol dehydrogenase family protein (TIGR02817; HMM-score: 27.8)
    Metabolism Energy metabolism Amino acids and amines sarcosine oxidase, alpha subunit family (TIGR01372; HMM-score: 9.6)
  • TheSEED: see SP70585_2143
  • PFAM:
    GroES (CL0296) ADH_N; Alcohol dehydrogenase GroES-like domain (PF08240; HMM-score: 101)
    and 6 more
    NADP_Rossmann (CL0063) ADH_zinc_N; Zinc-binding dehydrogenase (PF00107; HMM-score: 75)
    Glu_dehyd_C; Glucose dehydrogenase C-terminus (PF16912; HMM-score: 32.3)
    ADH_zinc_N_2; Zinc-binding dehydrogenase (PF13602; HMM-score: 21.3)
    AlaDh_PNT_C; Alanine dehydrogenase/PNT, C-terminal domain (PF01262; HMM-score: 21)
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase (PF07992; HMM-score: 12.6)
    FAD_binding_2; FAD binding domain (PF00890; HMM-score: 10.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.043871
    • TAT(Tat/SPI): 0.000298
    • LIPO(Sec/SPII): 0.001667
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MKAYTYVKPGLASFVDVDKPVIRKPTDAIVRIVKTTICGTDLHIIKGDVPTCQSGTILGHEGIGIVEEVGEGVSNFKKGDKVLISCVCACGKCYYCKKGIYAHCEDEGGWIFGHLIDGMQAEYLRVPHADNTLYHTPEDLSDEALVMLSDILPTGYEIGVLKGKVEPGCSVAIIGSGPVGLAALLTAQFYSPAKLIMVDLDDNRLDTALSFGATHKVNSSDPEKAIKEIYDLTDGRGVDVAIEAVGIPETFDFCQKIIGVDGTVANCGVHGKPVEFDLDKLWIRNINVTTGLVSTNTTPQLLKALESHKIEPEKLVTHYFKLSEIEKAYEVFSKAADHHAIKVIIENDISEA

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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